EIF2B1
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Official Full Name
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa -
Overview
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009] -
Synonyms
EIF2B1;eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa;EIF2B;EIF2BA;translation initiation factor eIF-2B subunit alpha;eIF-2B GDP-GTP exchange factor subunit alpha
Recombinant Proteins
- Rat
- Zebrafish
- Human
- Cynomolgus
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
EIF2B1 involved in several pathways and played different roles in them. We selected most pathways EIF2B1 participated on our site, such as Cap-dependent Translation Initiation,Eukaryotic Translation Initiation,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Translation | EEF1A2,EEF1G,EIF5,APEH,EEF1D,EEF1B2 |
| Metabolism of proteins | WIPI1,TIMM17B,CPB2,TBCB,GPR120,NEU3,SPON1B,B3GNT3,EIF5,ZNF408 |
| RNA transport | STRAP,PABPC1A,EIF2B2,SMN,EEF1A1L2,NMD3,NUP54,SEH1L,RPP21,EIF4EBP2 |
| Gene Expression | ZNF167,ZNF136,SKIA,EEF1A2,SNUPN,TP53RK,ZNF436,ZFP2,ZNF544,PRDX2 |
| Eukaryotic Translation Initiation | RPL35,EIF4G1,EIF3K,EIF4A2,EIF5,EIF4A1,EIF1AX,FAUB,EIF2S1,EIF2S1A |
| Translation Factors | EEF1A2,EEF1G,EEF2B,EEF1D,EIF4EBP2,EIF5A,EIF1,EEF1B2,PAIP1 |
| Cap-dependent Translation Initiation | EIF2S1A,FAUB,EIF1AXA,EIF4H,EIF4E,EIF4A2,EIF5,EIF3K,RPL35,EIF4G1 |
Protein Function
EIF2B1 has several biochemical functions, for example, GDP binding,GTP binding,NOT S-methyl-5-thioribose-1-phosphate isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2B1 itself. We selected most functions EIF2B1 had, and list some proteins which have the same functions with EIF2B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to translation initiation factor activity | EIF3M,EIF3I,EIF3S6IP,EIF3L,EIF3E,EIF3K,EIF3S10,EIF3BA,EIF2B3,EIF3G |
| enzyme regulator activity | PSMD2,APOC3,RAB3GAP2,DPM2,BRCC3,MTMR9,RGN,CPN2,GCLM,SEPT2 |
| NOT S-methyl-5-thioribose-1-phosphate isomerase activity | EIF2B2,EIF2B3,EIF2B4 |
| protein binding | IL5RA,CNOT2,GTF2H2,JRK,LDLRAP1,PCSK5,PRIMPOL,GPC3,NAT8B,UBQLN4 |
| GTP binding | EHD1B,SRP54,RHOJ,GIMAP5,TUBA3D,ARL4CB,HRAS,SEPT8A,GTPBP4,TUBA4A |
| GDP binding | RAB9B,RAB17,RAB14,RRAS,RAB27A,RAB28,PRPS2,RAB4A,RAB3B,RAB22A |
| contributes_to guanyl-nucleotide exchange factor activity | HBXIP,EIF2B4,ALS2,C7orf59,EIF2B2,LAMTOR3,LAMTOR1,EIF2B3,LAMTOR2,EIF2B5 |
Interacting Protein
EIF2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2B1.
RD3;WDYHV1;GORASP2;Adra2b;Adra2a;ADRB2;7242199;PDIA4;HNRNPL;Adrb2
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References
- Robinson, ME; Rossignol, E; et al. Vanishing White Matter Disease in French-Canadian Patients From Quebec. PEDIATRIC NEUROLOGY 51:225-232(2014).
- Zahoor, I; Hamid, Z; et al. Novel mutations identified in EIF2B5 gene in Kashmiri patients as susceptibility factor for multiple sclerosis. INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 51:115-120(2014).
