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Official Full Name eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
Background Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation.
Synonyms EIF2S2; eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; EIF2, eukaryotic translation initiation factor 2, subunit 2 (beta, 38kD ); eukaryotic translation initiation factor 2 subunit 2; EIF2beta; PPP1R67; protein phosphatase 1; regulato
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF2S2-2521H Recombinant Human EIF2S2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human EIF2S2-3173H Recombinant Human EIF2S2 Protein, GST-tagged Wheat Germ GST
    Human EIF2S2-354H Recombinant Human EIF2S2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EIF2S2-6665HCL Recombinant Human EIF2S2 293 Cell Lysate HEK293 N/A
    Mouse Eif2s2-2776M Recombinant Mouse Eif2s2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque EIF2S2-1420R Recombinant Rhesus monkey EIF2S2 Protein, His-tagged Mammalian Cell His
    Chicken EIF2S2-6166C Recombinant Chicken EIF2S2 Mammalian Cell His
    Zebrafish EIF2S2-11951Z Recombinant Zebrafish EIF2S2 Mammalian Cell His

    EIF2S2 involved in several pathways and played different roles in them. We selected most pathways EIF2S2 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2S2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport NXT1; EIF4G3; XPOT; NUP205; THOC3; RPP30; FMR1; SUMO1; XPO1; EIF4EBP3

    EIF2S2 has several biochemical functions, for example, RNA binding, metal ion binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2S2 itself. We selected most functions EIF2S2 had, and list some proteins which have the same functions with EIF2S2. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding ZMYND12; ZMYND15; ZFP330; ZFP35; IRF2BP2A; INSM2; STEAP3; NT5C; UNK; OVOL1
    poly(A) RNA binding COA6; AKAP8L; EIF4H; Txn1; TFAM; PIN4; MRPL1; NSA2; ISG20L2; ALDOA
    protein binding KCNIP2; C4orf26; HSFX1; GGA1; DYNLT1; SESN2; CPNE7; DHPS; SMYD2; KTI12
    translation factor activity, RNA binding CPEB1; EIF2S3; EIF1; EEF1A2; CPEB3; EIF4G3; CPEB1B; EIF4G1; EIF4G2; CPEB4
    translation initiation factor activity EIF3F; EIF4A1; EIF3BA; EIF4H; EIF3S10; EIF2S2; EIF1AXB; EIF4E1B; EIF4A1B; EIF4EA

    EIF2S2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2S2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2S2.

    EIF2S1; EIF4G2; EIF2S3; CSNK2A1; EIF2B2; oks16_human; TP53; APLP1; TLE1; ZBTB16

    Gatza, ML; Silva, GO; et al. An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer. NATURE GENETICS 46:1051-1059(2014).
    Heaney, JD; Michelson, MV; et al. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. HUMAN MOLECULAR GENETICS 18:1395-1404(2009).

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