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Official Full Name eukaryotic translation initiation factor 4A3
Background This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family.
Synonyms EIF4A3; eukaryotic translation initiation factor 4A3; DDX48, DEAD (Asp Glu Ala Asp) box polypeptide 48 , eukaryotic translation initiation factor 4A, isoform 3; eukaryotic initiation factor 4A-III; EIF4AIII; KIAA0111; NMP 265; hNMP 265; eIF4A-III; eIF-4
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF4A3-12377H Recombinant Human EIF4A3, GST-tagged E.coli GST
    Human EIF4A3-1334H Recombinant Human Eukaryotic Translation Initiation Factor 4A3, His-tagged E.coli His
    Human EIF4A3-2494H Recombinant Human EIF4A3 Protein, GST-tagged Wheat Germ GST
    Human EIF4A3-27410TH Recombinant Human EIF4A3, His-tagged E.coli His
    Human EIF4A3-6652HCL Recombinant Human EIF4A3 293 Cell Lysate HEK293 N/A
    Mouse EIF4A3-5104M Recombinant Mouse EIF4A3 Protein Mammalian Cell His
    Rat EIF4A3-2065R Recombinant Rat EIF4A3 Protein Mammalian Cell His
    Cynomolgus Monkey EIF4A3-489C Recombinant Cynomolgus EIF4A3 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque EIF4A3-1427R Recombinant Rhesus monkey EIF4A3 Protein, His-tagged Mammalian Cell His
    Chicken EIF4A3-2356C Recombinant Chicken EIF4A3 Mammalian Cell His
    Zebrafish EIF4A3-11304Z Recombinant Zebrafish EIF4A3 Mammalian Cell His

    EIF4A3 involved in several pathways and played different roles in them. We selected most pathways EIF4A3 participated on our site, such as RNA transport, mRNA surveillance pathway, Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport UPF3A; RPP40; FMR1; NUP62L; RAN; ELAC2; NUP107; EIF4BA; SEH1L; RPP25L
    mRNA surveillance pathway PPP1CB; RNGTT; PABPC5; GSPT2; PPP2R5A; PPP1CAA; ALYREF; NCBP2; CPSF6; SSU72
    Spliceosome CDC40; SRSF1A; SYF2; SF3B3; HSC70; HNRNPA1A; SNRPE; FAM120B; SRSF7B; PRPF38B

    EIF4A3 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4A3 itself. We selected most functions EIF4A3 had, and list some proteins which have the same functions with EIF4A3. You can find most of the proteins on our site.

    Function Related Protein
    ATP-dependent RNA helicase activity G3BP1; DHX33; DDX54; EIF4A1; DDX3X; DHX9; EIF4A2; SNRNP200; DDX46; DDX39A
    mRNA binding EIF4ENIF1; RPS2; FMR1; RBFOX1L; PAIP2; CELF3; NXF2; DCP1B; CPSF5; G3BP1
    poly(A) RNA binding DDX24; RPL5B; HNRNPH1; KRR1; NCL; CSDA; FAM98C; HDLBP; QK; MBNL3
    protein binding VEPH1; TAF1A; ZNF703; ADA; KRT2; MED16; INVS; TAX1BP1; SSNA1; RHBDL1

    EIF4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4A3.


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