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Recombinant Human EIF4A3, GST-tagged

Cat.No. : EIF4A3-12377H
Product Overview : Recombinant Human EIF4A3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Availability February 16, 2025
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Description : This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-411a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : EIF4A3 eukaryotic translation initiation factor 4A3 [ Homo sapiens ]
Official Symbol : EIF4A3
Synonyms : EIF4A3; eukaryotic translation initiation factor 4A3; DDX48, DEAD (Asp Glu Ala Asp) box polypeptide 48 , eukaryotic translation initiation factor 4A, isoform 3; eukaryotic initiation factor 4A-III; EIF4AIII; KIAA0111; NMP 265; hNMP 265; eIF4A-III; eIF-4A-III; DEAD box protein 48; nuclear matrix protein 265; ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; eukaryotic initiation factor 4A-like NUK-34; eukaryotic translation initiation factor 4A, isoform 3; DDX48; NUK34; NMP265; eIF4AIII; MGC10862; DKFZp686O16189;
Gene ID : 9775
mRNA Refseq : NM_014740
Protein Refseq : NP_055555
MIM : 608546
UniProt ID : P38919
Chromosome Location : 17q25.3
Pathway : Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Deadenylation of mRNA, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Exon junction complex (EJC), organism-specific biosystem; Gene Expression, organism-specific biosystem; ISG15 antiviral mechanism, organism-specific biosystem;
Function : ATP binding; ATP-dependent RNA helicase activity; RNA binding; helicase activity; hydrolase activity; nucleotide binding; poly(A) RNA binding; protein binding;

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04/30/2022

    The product's user-friendly features facilitated seamless collaboration among team members with different expertise levels.

    03/10/2019

      The product's established reputation in the scientific community provided assurance of its reliability.

      07/25/2018

        It's batch-to-batch consistency was a key factor in the success of our long-term research projects.

        Q&As (7)

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        Are there specific RNA targets or motifs recognized by EIF4A3, and what is their functional significance? 11/16/2022

        Specific RNA targets or motifs recognized by EIF4A3 include splice sites and exon junctions, with functional significance in maintaining mRNA integrity.

        In which cellular compartments is EIF4A3 predominantly localized? 03/09/2022

        EIF4A3 is predominantly localized in the nucleus and cytoplasm of cells, contributing to its involvement in RNA-related processes.

        How does EIF4A3 contribute to the regulation of RNA metabolism, including splicing and translation? 10/05/2020

        EIF4A3 contributes to the regulation of RNA metabolism by participating in splicing, translation initiation, and mRNA surveillance.

        Are there therapeutic implications or potential targets related to EIF4A3 in diseases involving RNA metabolism? 04/29/2019

        There are potential therapeutic implications related to EIF4A3 in diseases involving RNA metabolism, making it a target for drug development.

        How does EIF4A3 influence the balance between mRNA quality control and translation efficiency? 03/15/2018

        EIF4A3 influences the balance between mRNA quality control, including nonsense-mediated decay, and translation efficiency.

        What is the primary function of eukaryotic translation initiation factor 4A3 (EIF4A3) in cellular processes? 02/22/2018

        Eukaryotic translation initiation factor 4A3 (EIF4A3) primarily functions in cellular processes, playing a role in RNA metabolism, including splicing and translation.

        What diseases or conditions are associated with dysregulation or abnormal expression of EIF4A3? 09/10/2017

        Dysregulation or abnormal expression of EIF4A3 is associated with conditions such as cancer and neurodegenerative disorders.

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