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EIF4G2

Official Full Name

eukaryotic translation initiation factor 4 gamma, 2
Overview

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation;factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The;protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for;eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports;cap-dependent and independent translation, this gene product functions as a general repressor of translation by;forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA;initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms;of this gene have been described.
Synonyms

EIF4G2; eukaryotic translation initiation factor 4 gamma, 2; eukaryotic translation initiation factor 4 gamma 2; DAP5; NAT1; p97; DAP-5; eIF4G 2; eIF-4G 2; eIF-4-gamma 2; aging-associated protein 1; death-associated protein 5; eukaryotic translation initi;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	EIF4G2-3211H	Recombinant Human EIF4G2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	EIF4G2-6646HCL	Recombinant Human EIF4G2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	EIF4G2-3683H	Recombinant Human EIF4G2 protein, His-tagged	E.coli	His	563-907 aa	$319 / 25ug
Mouse	EIF4G2-5115M	Recombinant Mouse EIF4G2 Protein	Mammalian Cell	His		Inquiry
Mouse	EIF4G2-2725M-B	Recombinant Mouse EIF4G2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	EIF4G2-2725M	Recombinant Mouse EIF4G2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	EIF4G2-3725C	Recombinant Chicken EIF4G2	Mammalian Cell	His		Inquiry
Chicken	EIF4G2-3423C	Recombinant Chicken EIF4G2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
EIF4G2 Related Signal Pathway

EIF4G2 involved in several pathways and played different roles in them. We selected most pathways EIF4G2 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4G2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Antiviral mechanism by IFN-stimulated genes	EIF4EB;IFIT10;DPF1;EIF4E;EIF4G1;ARIH1L;IFIT12;KPNA5;IFIT14
Cytokine Signaling in Immune system	EDARADD;IFITM3;SPRED3;ISG20;TRIM48;PEA15;GHRB;GBP4;TRIM3
Diurnally regulated genes with circadian orthologs	CRY1;UCP3;STBD1;CBX3;CEBPB;AZIN1;RBPMS;SF3A3;TOB1
ISG15 antiviral mechanism	IFIT8;EIF4G2A;MX2;IFIT12;IFIT11;KPNA5;KPNA3;ARIH1L;KPNA4
Immune System	RACGAP1;DCTN3;HCST;DEFA1;SIGLEC8;ERAP2;MGC174152;LAT2;CTS7
Interferon Signaling	IRF4;IFI35;FCGR1B;TRIM14;SAMHD1;BST2;TRIM68;EIF4G2A;EIF4G2
RNA transport	EIF4E1B;PABPC1L2A;EIF4E2RS1;SARNP;NUP188;NUP133;SUMO4;POP4;NXF1
Viral myocarditis	HLA-DMB;LAMA2;HLA-B;ITGAL;CD28;MYH7;H2-AA;HLA-DOB;HLA-DOA

EIF4G2 has several biochemical functions, for example, poly(A) RNA binding, protein binding, translation factor activity, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4G2 itself. We selected most functions EIF4G2 had, and list some proteins which have the same functions with EIF4G2. You can find most of the proteins on our site.

Function	Related Protein
poly(A) RNA binding	TRMT2A;RPS7;CSTF2;HMGN2;CDK11B;HNRPLL;LARP4;DHX15;RPL35
protein binding	MATN2;DUSP21;CCNL2;RAB6A;C7orf59;TSSK4;CALCA;BAG3;GALR1
translation factor activity, RNA binding	EIF4G2;PPP1R2P9;EIF4H;EEF1D;CPEB2;CPEB4;MTIF3;GTF2H3;GTF2H2
translation initiation factor activity	EIF3E;EIF4EB;EIF3JA;EIF4E2RS1;COPS5;EIF3J;EIF2S1;EIF3S6IP;EIF2S1A

EIF4G2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4G2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4G2.

EIF4A1; EIF2S2; EIF4A2; HSPB1; EIF2S1; Dlg4; EIF3H; PTP4A3; EIF3J; CIAO1; MAGEA6