EIF4H
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Official Full Name
eukaryotic translation initiation factor 4H -
Overview
A variety of factors contribute to the initiation of translation. Eukaryotic translation initiation factor 4H (eIF4H) was purified to near homogeneity from rabbit reticulocyte lysate and shown to stimulate translation in an assay deficient in eIF4F and eI -
Synonyms
EIF4H;eukaryotic translation initiation factor 4H;WBSCR1, Williams Beuren syndrome chromosome region 1;KIAA0038;WSCR1;Williams-Beuren syndrome chromosome region 1;WBSCR1;eIF-4H
Recombinant Proteins
- Rhesus macaque
- Rat
- Chicken
- Human
- Zebrafish
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- Avi
- Fc
- DDK
- Myc
- GST
Involved Pathway
EIF4H involved in several pathways and played different roles in them. We selected most pathways EIF4H participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,Cap-dependent Translation Initiation,Eukaryotic Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | SKIB,NR5A1A,PAPOLA,EED,HNRNPUL1,ALKBH8,ADAT2,ZNF43,ZNF620,ELL |
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | FAUB,EIF4G1,EIF2S1,EIF2S1A,EIF4E,EIF4EBP1,EIF3K,EIF1AX,EIF2S3,EIF4A1 |
| Metabolism of proteins | CPB1,ST6GALNAC2,INHBAA,PPP6R1,FXC1,MIA3,MUC1,B3GNT8,EIF5A2,CNIH |
| GTP hydrolysis and joining of the 60S ribosomal subunit | EIF4A2,EIF3K,FAUB,EIF1AX,RPL35,EIF5,EIF4A1,EIF4B,EIF1AXA,EIF2S1 |
| Eukaryotic Translation Initiation | FAUB,EIF2S1,EIF1AXA,EIF1AX,EIF4G1,EIF4A1,EIF4A2,EIF4B,EIF2B1,EIF2S3 |
| L13a-mediated translational silencing of Ceruloplasmin expression | EIF1AX,EIF2S1A,EIF2S3,EIF1AXA,EIF3K,FAUB |
| Ribosomal scanning and start codon recognition | EIF5 |
| Cap-dependent Translation Initiation | EIF1AX,EIF4G1,EIF4B,EIF1AXA,EIF4EBP1,EIF2S3,EIF4A2,RPL35,EIF4EB,EIF4A1 |
Protein Function
EIF4H has several biochemical functions, for example, RNA binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4H itself. We selected most functions EIF4H had, and list some proteins which have the same functions with EIF4H. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | MEPCE,TXN,LARP4,RPS2,MTIF2,STRAP,CDC42EP4,HIST1H4N,MDH2,RPS17L |
| nucleotide binding | PTK2AA,ATP9A,SFPQ,EWSR1,HNRNPH3,MTIF2,UBE2D1A,HPRT1,PLK2B,HNRNPA0 |
| translation factor activity, RNA binding | EIF4A1,PPP1R2P9,EIF1,EIF5,GTF2H2,CPEB1B,CPEB1,EEF1D,EIF4G1,ABCF1 |
| RNA binding | ATXN1A,POP4,CPSF5,Aff2,EXOSC9,IFIT5,NANOS1,MARF1,EXOSC5,PUS7L |
| protein binding | ZNHIT1,PTPN12,SNRNP25,KCNJ6,INHBB,GNL3,TGFBR2,CRB1,RASGRP3,GLRA1 |
| translation initiation factor activity | EIF3F,EIF3B,MTIF2,EIF1AX,EIF2S1B,COPS5,EIF1AY,EIF4E3,EIF2A,EIF4G1 |
Interacting Protein
EIF4H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4H here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4H.
C11orf68;LNX1;EIF4A1;EIF1B;MCC;IKBKE;ychF;rfbD;ssrna_ug
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References
- Sun, YJ; Atas, E; et al. Single-Molecule Kinetics of the Eukaryotic Initiation Factor 4AI upon RNA Unwinding. STRUCTURE 22:941-948(2014).
- Zhu, YF; Hultin-Rosenberg, L; et al. SpliceVista, a Tool for Splice Variant Identification and Visualization in Shotgun Proteomics Data. MOLECULAR & CELLULAR PROTEOMICS 13:1552-1562(2014).
