EIF4H

  • Official Full Name

    eukaryotic translation initiation factor 4H
  • Overview

    A variety of factors contribute to the initiation of translation. Eukaryotic translation initiation factor 4H (eIF4H) was purified to near homogeneity from rabbit reticulocyte lysate and shown to stimulate translation in an assay deficient in eIF4F and eI
  • Synonyms

    EIF4H;eukaryotic translation initiation factor 4H;WBSCR1, Williams Beuren syndrome chromosome region 1;KIAA0038;WSCR1;Williams-Beuren syndrome chromosome region 1;WBSCR1;eIF-4H

Recombinant Proteins

  • Rhesus macaque
  • Rat
  • Chicken
  • Human
  • Zebrafish
  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
EIF4H-1433R Recombinant Rhesus monkey EIF4H Protein, His-tagged Mammalian Cells Rhesus macaque His
EIF4H-2068R Recombinant Rat EIF4H Protein Mammalian Cells Rat His
EIF4H-3618C Recombinant Chicken EIF4H Mammalian Cells Chicken His
EIF4H-6789H Recombinant Human Eukaryotic Translation Initiation Factor 4H, His-tagged E.coli Human His
EIF4H-7829Z Recombinant Zebrafish EIF4H Mammalian Cells Zebrafish His
EIF4H-6643HCL Recombinant Human EIF4H 293 Cell Lysate HEK293 Human Non
EIF4H-1257R Recombinant Rhesus Macaque EIF4H Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
EIF4H-1257R-B Recombinant Rhesus Macaque EIF4H Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
EIF4H-1725R Recombinant Rat EIF4H Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
EIF4H-1725R-B Recombinant Rat EIF4H Protein Pre-coupled Magnetic Beads HEK293 Rat
Eif4h-2790M Recombinant Mouse Eif4h Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
EIF4H-30161H Recombinant Human EIF4H protein, GST-tagged E.coli Human GST Met1-Arg188
EIF4H-3614H Recombinant Human EIF4H Protein (Ala2-Glu248), N-His tagged E.coli Human His Ala2-Glu248
EIF4H-4894H Recombinant Human EIF4H Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
EIF4H-5267H Recombinant Human EIF4H Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc

    Involved Pathway

    EIF4H involved in several pathways and played different roles in them. We selected most pathways EIF4H participated on our site, such as Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S,Cap-dependent Translation Initiation,Eukaryotic Translation Initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF4H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Eukaryotic Translation Initiation EIF4A2,EIF2S1,EIF2S1A,EIF4A1,EIF5,EIF2B1,EIF2S3,FAUB,EIF1AXA,EIF4B
    Ribosomal scanning and start codon recognition EIF5
    Cap-dependent Translation Initiation EIF2S1A,EIF3K,EIF4A1,EIF4G1,EIF2S1,EIF2S3,EIF2B1,RPL35,EIF5,EIF1AX
    GTP hydrolysis and joining of the 60S ribosomal subunit EIF2S1A,FAUB,EIF4A1,RPL35,EIF4A2,EIF2S3,EIF4B,EIF3K,EIF1AXA,EIF5
    L13a-mediated translational silencing of Ceruloplasmin expression FAUB,EIF1AXA,EIF3K,EIF2S3,EIF2S1A,EIF1AX
    Gene Expression GM3258,EHMT2,EIF1AXA,DPY19L2,ZNF747,HNRNPA0A,SNAPC1B,ZNF557,QTRT1,KRBOX4
    Metabolism of proteins ZDHHC2,TBCD,TIMM17A,NAT8,B3GNT6,O3far1,FXC1,EXOSC8,PDIA6,TIMM22
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF4EB,FAUB,EIF4B,EIF2S1,EIF4G1,EIF4A1,EIF3K,EIF2S1A,EIF4EBP1,EIF4A2

    Protein Function

    EIF4H has several biochemical functions, for example, RNA binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF4H itself. We selected most functions EIF4H had, and list some proteins which have the same functions with EIF4H. You can find most of the proteins on our site.

    Function Related Protein
    nucleotide binding UCK2A,HNRNPA0,CAMK2B1,FGFR1A,GNA13B,MTIF2,MSI2A,SGK2A,STK35L,PFKMA
    translation factor activity, RNA binding CPEB3,CPEB2,EEF1D,SOX11,EIF1AX,MTIF3,EIF1,EEF1A2,EIF2S2,PPP1R2P9
    poly(A) RNA binding SOSTDC1B,MRPS35,ZCCHC8,MANF,DDX24,CSTF1,TCOF1,ELAVL2,ZC3H14,DIDO1
    RNA binding ADAD1,TRIM71,OOEP,RBMS1,TLR13,THOC1,RPL7A,RBM48,RBM4.1,DDX17
    protein binding TBC1D9B,BMP1,GUCY1B3,C4orf19,AGR3,IRF7,SERP1,RBM39,FOS,THRAA
    translation initiation factor activity BRF1A,EIF6,AGO2,EIF4B,EIF4BB,EIF3E,EIF3BA,EIF3EB,EIF4A2,EIF3HA

    Interacting Protein

    EIF4H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF4H here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF4H.

    C11orf68;LNX1;EIF4A1;EIF1B;MCC;IKBKE;ychF;rfbD;ssrna_ug

    Resources

    References

    • Sun, YJ; Atas, E; et al. Single-Molecule Kinetics of the Eukaryotic Initiation Factor 4AI upon RNA Unwinding. STRUCTURE 22:941-948(2014).
    • Zhu, YF; Hultin-Rosenberg, L; et al. SpliceVista, a Tool for Splice Variant Identification and Visualization in Shotgun Proteomics Data. MOLECULAR & CELLULAR PROTEOMICS 13:1552-1562(2014).

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