Recombinant Mouse Eif4h Protein, Myc/DDK-tagged

• Cat.No.: Eif4h-2790M
• Product Overview: Purified recombinant protein of mouse full-length eukaryotic translation initiation factor 4H (cDNA clone MGC:11689 IMAGE:3962104), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes eukaryotic translation initiation factor 4H (eIF4H) that plays a critical role in the process of protein synthesis. The encoded protein is an RNA-binding protein that, in concert with other translation initiation factors, helps unwind the 5' cap-proximal region of mRNA to prepare it for ribosomal attachment. Mice lacking the encoded protein displayed growth retardation with a significant reduction of body weight, a smaller brain volume and altered brain morphology. Behaviorally, mice lacking the encoded protein exhibit severe impairments of fear-related associative learning and memory formation. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Molecular Mass: 25.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Eif4h eukaryotic translation initiation factor 4H [ Mus musculus (house mouse) ]
• Official Symbol: Eif4h
• Synonyms: Eif4h; eukaryotic translation initiation factor 4H; Wsc; Ef4h; Eif4; Wbsc; Wscr1; Wbscr1; eIF-4H; AU018978; D5Ertd355; D5Ertd355e; E430026L18Rik; eukaryotic translation initiation factor 4H; williams-Beuren syndrome chromosomal region 1 protein homolog
• Gene ID: 22384
• mRNA Refseq: NM_033561
• Protein Refseq: NP_291039
• UniProt ID: Q9WUK2