Epha2 Protein


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Official Full Name EPH receptor A2
Background This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.
Synonyms EPHA2; EPH receptor A2; ECK, EphA2; ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase; ECK; CTPA; ARCC2; CTPP1
    • Species :
    • Dog
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human Cells
    • In Vitro Cell Free System
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • DDK
    • His
    • Fc
    • Fc Chimera
    • Flag
    • GST
    • His&Myc
    • Myc
    • His-Avi
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Epha2-197M Active Recombinant Mouse Epha2, Fc Chimera Mammalian cells Fc Chimera Inquiry
    Human EPHA2-2028H Active Recombinant Human EPHA2 Protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Inquiry
    Human EPHA2-26740TH Recombinant Human EPHA2 Wheat Germ N/A Inquiry
    Human EPHA2-300H Recombinant Human EPH Receptor A2, GST-tagged, Active Sf9 Insect Cell GST Inquiry
    Human EPHA2-3378H Recombinant Human EPHA2 Protein, GST-tagged Wheat Germ GST Inquiry
    Human EPHA2-359H Recombinant Human EPHA2 Protein, DDK/His-tagged HEK293 DDK/His Inquiry
    Human EPHA2-360H Recombinant Human EPHA2 Protein, DDK-tagged Insect Cell DDK Inquiry
    Human EPHA2-409H Recombinant Human EPHA2, His tagged Human Cell Fc Inquiry
    Human EPHA2-541H Recombinant Human EPH Receptor A2, His-tagged Sf9 Insect Cell His Inquiry
    Human EPHA2-8628H Recombinant Human EPHA2, His & GST tagged Insect Cell His/GST Inquiry
    Mouse Epha2-1722M Recombinant Mouse Eph Receptor A2 Mammalian cells N/A Inquiry
    Mouse Epha2-914M Recombinant Mouse Epha2, His tagged Human Cell His Inquiry
    Rhesus Macaque EPHA2-1483R Recombinant Rhesus monkey EPHA2 Protein, His-tagged Mammalian Cell His Inquiry
    Human EPHA2-001HCL Recombinant Human EPHA2 cell lysate Insect Cell N/A Inquiry
    Human EPHA2-1072HCL Recombinant Human EPHA2 cell lysate Human Cell N/A Inquiry
    Mouse EPHA2-2138MCL Recombinant Mouse EPHA2 cell lysate Human Cell N/A Inquiry
    Dog EPHA2-01D Recombinant Dog EPHA2 Protein, Fc-tagged HEK293 Fc Inquiry
    Human EPHA2-151H Recombinant Human EPHA2 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK Inquiry
    Human EPHA2-152HF Recombinant Full Length Human EPHA2 Protein In Vitro Cell Free System Inquiry
    Human EPHA2-4343HF Recombinant Full Length Human EPHA2 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human EPHA2-5009H Recombinant Human EPHA2 protein, His&Myc-tagged HEK293 His&Myc Inquiry
    Human EPHA2-698HFL Recombinant Full Length Human EPHA2 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Human EPHA2-1903H Recombinant Human EPHA2 Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human EPHA2-2027H Recombinant Human EPHA2 Protein, His-tagged HEK293 His Inquiry
    Human EPHA2-2515H Recombinant Human EPHA2 Protein (28-328 aa), His-Myc-tagged E.coli His/Myc Inquiry
    Human EPHA2-321H Recombinant Human EPHA2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK Inquiry
    Mouse Epha2-197MA Recombinant Mouse Epha2 protein, Fc-tagged, APC labeled Mammalian cells Fc Inquiry
    Mouse Epha2-197MP Recombinant Mouse Epha2 protein, Fc-tagged, R-PE labeled Mammalian cells Fc Inquiry
    Mouse Epha2-954M Recombinant Mouse Epha2 Protein, MYC/DDK-tagged HEK293T MYC/DDK Inquiry
    Kit-0326 EphA2 Kinase (Human) Assay/Inhibitor Screening Assay Kit N/A Inquiry

    Epha2 involved in several pathways and played different roles in them. We selected most pathways Epha2 participated on our site, such as Arf6 signaling events, Axon guidance, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with Epha2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arf6 signaling events IPCEF1; AGTR1; USP6; EPHA2; EFNA1; GULP1; EGFR; ARAP2; EGF; KIF13B
    Axon guidance PAK2; LRRC4C; NTNG1; SPTB; RASA1; PEA15; ARPC2; ARPC1A; PHB; SPTA1
    Developmental Biology CTNNA2; SEMA3AA; CACNG2B; BOC; CSNK2B; SPNA1; PEA15; COL4A3; FRS2B; NR5A1
    Direct p53 effectors CTSD; PLK3; CEBPZ; PPM1J; RNF144B; PRDM1; PCBP4; SMARCA4; DUSP1; CSE1L
    EPH-Ephrin signaling SDCBP; EFNA5; CLTB; ITSN1; ARPC5; EFNA3; AP2M1; EFNB1; MYL9; EPHA2A
    EPH-ephrin mediated repulsion of cells EFNA4; EFNB3B; AP2S1; AP2A2; EFNA3; CLTB; EPHB4A; EFNA1A; EFNA1B; EPHA4A
    EPHA forward signaling EPHA2; ARHGEF15; CRKL; EFNA5; EFNA3; EFNA2; EFNA1; BLK
    EPHA-mediated growth cone collapse EFNA4; MYL12B; EFNA3; EPHA2A; EFNA5; EFNA2A; KDR; EFNA3B; MYL9; EPHA2

    Epha2 has several biochemical functions, for example, ATP binding, ephrin receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Epha2 itself. We selected most functions Epha2 had, and list some proteins which have the same functions with Epha2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding LMTK2; TSSK2; DHX33; Abcb1b; ILK; PRKACBB; ACTBL2; ATP2B1A; KIF15; RAF1B
    ephrin receptor activity EPHB2B; EPHA10; EPHA4A; EPHA6; EPHB4B; EPHB3; EK1; EPHB4A; EPHA2; EPHA5
    protein binding CYLD; C1orf65; TDRD1; CDK17; ARHGEF3; SNAPIN; NRG1; CCND2; HERPUD1; TRAF3IP2
    transmembrane receptor protein tyrosine kinase activity KITA; FLT1; IGF1RB; NTRK3; NPTN; EPHA4A; NTRK2B; ERBB2; NTRK1; ROR1

    Epha2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Epha2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Epha2.

    EFNA1; EPHA7; HSP90AB1; PTK2; saicar; PKM; PTPN11; KPNA3

    Zhang, K; Geddie, ML; et al. Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle. MABS 7:42-52(2015).
    Iwahori, K; Kakarla, S; et al. Engager T Cells: A New Class of Antigen-specific T Cells That Redirect Bystander T Cells. MOLECULAR THERAPY 23:171-178(2015).

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