Recombinant Human EPHA2 Protein, GST-tagged

Cat.No. : EPHA2-3378H
Product Overview : Human EPHA2 full-length ORF ( NP_004422.2, 1 a.a. - 976 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 134.7 kDa
AA Sequence : MELQAARACFALLWGCALAAAAAAQ GKEVVLLDFAAAGGELGWLTHPYGK GWDLMQNIMNDMPIYMYSVCNVMSG DQDNWLRTNWVYRGEAERIFIELKF TVRDCNSFPGGASSCKETFNLYYAE SDLDYGTNFQKRLFTKIDTIAPDEI TVSSDFEARHVKLNVEERSVGPLTR KGFYLAFQDIGACVALLSVRVYYKK CPELLQGLAHFPETIAGSDAPSLAT VAGTCVDHAVVPPGGEEPRMHCAVD GEWLVPIGQCLCQAGYEKVEDACQA CSPGFFKFEASESPCLECPEHTLPS PEGATSCECEEGFFRAPQDPASMPC TRPPSAPHYLTAVGMGAKVELRWTP PQDSGGREDIVYSVTCEQCWPESGE CGPCEASVRYSEPPHGLTRTSVTVS DLEPHMNYTFTVEARNGVSGLVTSR SFRTASVSINQTEPPKVRLEGRSTT SLSVSWSIPPPQQSRVWKYEVTYRK KGDSNSYNVRRTEGFSVTLDDLAPD TTYLVQVQALTQEGQGAGSKVHEFQ TLSPEGSGNLAVIGGVAVGVVLLLV LAGVGFFIHRRRKNQRARQSPEDVY FSKSEQLKPLKTYVDPHTYEDPNQA VLKFTTEIHPSCVTRQKVIGAGEFG EVYKGMLKTSSGKKEVPVAIKTLKA GYTEKQRVDFLGEAGIMGQFSHHNI IRLEGVISKYKPMMIITEYMENGAL DKFLREKDGEFSVLQLVGMLRGIAA GMKYLANMNYVHRDLAARNILVNSN LVCKVSDFGLSRVLEDDPEATYTTS GGKIPIRWTAPEAISYRKFTSASDV WSFGIVMWEVMTYGERPYWELSNHE VMKAINDGFRLPTPMDCPSAIYQLM MQCWQQERARRPKFADIVSILDKLI RAPDSLKTLADFDPRVSIRLPSTSG SEGVPFRTVSEWLESIKMQQYTEHF MAAGYTAIEKVVQMTNDDIKRIGVR LPGHQKRIAYSLLGLKDQVNTVGIP I
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : EPHA2 EPH receptor A2 [ Homo sapiens ]
Official Symbol : EPHA2
Synonyms : EPHA2; EPH receptor A2; ECK, EphA2; ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase; ECK; CTPA; ARCC2; CTPP1;
Gene ID : 1969
mRNA Refseq : NM_004431
Protein Refseq : NP_004422
MIM : 176946
UniProt ID : P29317

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the treatment strategies for EPHA2? 08/01/2021

Therapeutic strategies for EPHA2 include inhibition of its expression, blocking its signal transduction pathway, and modulating its interaction with ligands. These strategies may involve the use of small molecule inhibitors, antibodies, or other types of therapeutics.

How does EPHA2 expression level relate to the occurrence and progression of the disease? 07/27/2021

The expression level of EPHA2 is associated with the occurrence and progression of a variety of diseases. For example, in tumors such as lung, breast, and colorectal cancer, EPHA2 expression levels may be elevated and correlated with the degree of malignancy and poor prognosis of the tumor.

How does EPHA2 expression level relate to tumor prognosis? 06/10/2021

In some tumors, EPHA2 expression levels are associated with poor prognosis in patients. For example, patients with lung cancer who express EPHA2 often have shorter survival. Therefore, the expression level of EPHA2 may be one of the indicators to predict tumor prognosis.

How can diseases be diagnosed by detecting EPHA2 expression levels? 05/21/2021

Some diseases can be diagnosed by measuring EPHA2 expression levels, such as immunohistochemistry, western blotting, and real-time PCR.

Could EPHA2 be used as a target for the treatment of certain diseases? 10/18/2020

Yes, EPHA2 can be used as a target for the treatment of certain diseases. For example, inhibition of EPHA2 expression can inhibit tumor growth and spread, so EPHA2 can serve as a potential therapeutic target. In addition, regulating the expression level of EPHA2 may also be helpful in the treatment of diseases such as the nervous system and cardiovascular system.

What is the role of EPHA2 in cancer metastasis? 08/22/2020

EPHA2 can promote cancer metastasis and affect the spread and spread of cancer by regulating processes such as invasion and migration of tumor cells. Therefore, inhibition of EPHA2 expression or blocking its signal transduction pathway may have a potential therapeutic effect on inhibiting cancer metastasis.

Customer Reviews (3)

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Reviews
12/21/2022

    The protein has low cytotoxicity.

    02/03/2022

      EPHA2 has good stability, and the test results of heat resistance, acid and alkali resistance and protease degradation resistance are good.

      03/31/2021

        Kinetic parameters such as enzymatic reaction rate and binding affinity were tested, and the protein performed well.

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