Recombinant Human EPH Receptor A2, His-tagged EPHA2-541H

Recombinant Human EPH Receptor A2, His-tagged


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Recombinant Human EPH Receptor A2, His-tagged

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Cat.No. : EPHA2-541H Optional Service: Optional requirements on this protein
Product Overview : Recombinant human EPHA2 was expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag. MW=47kDa.
Description : EPHA2 is a member of the ephrin receptor subfamily of protein-tyrosine kinases that bind the ephrin-A ligand and have diverse cellular function. EPHA2 has been shown to be an oncoprotein of importance in a range of cancers. EPHA2 is overexpressed in several human cancer types and promotes malignancy through a mechanism involving RhoA-dependent destabilization of adherens junctions. EPHA2 overexpression induces a FAK-dependent increase in MMP-2 expression and invasiveness and this process that can be reversed by ligation of EPHA2.
Source : Sf9 insect cells.
Purity : >90%.
Specific Activity : 170 U/mg. One unit is defined as the amount of enzyme that will phosphorylate 1 nmol of tyrosine substrate per minute at pH 7.4 and 30ºC. Assay buffer: 50 mM HEPES, pH 7.4, 3 mM MgCl2, 3 mM MnCl2, 1 mM DTT, 3 μM Na-orthovanadate, 0.1 mM ATP, 30 μg/ml Poly (Glu:Tyr) 4:1 substrate, and 0.1 μg /ml recombinant EPHB2.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Formulated In : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 50% glycerol and 3mM DTT.
Stability : >12 months at –80°C.
PDB rendering based on 1mqb. :

Gene Name : EPHA2 EPH receptor A2 [ Homo sapiens ]
Synonyms : EPHA2; EPH receptor A2; ECK; ARCC2; protein tyrosine kinase; soluble EPHA2 variant 1; soluble EPHA2 variant 1; epithelial cell receptor protein tyrosine kinase; ephrin receptor EphA2; EC
Gene ID : 1969
mRNA Refseq : NM_004431
Protein Refseq : NP_004422
MIM : 176946
UniProt ID : P29317
Chromosome Location : 1p36
Pathway : Axon guidance
Function : ATP binding; ephrin receptor activity; nucleotide binding; protein binding; receptor activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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