Active Recombinant Human EPHA2 protein, His-tagged
Cat.No. : | EPHA2-2619H |
Product Overview : | Active Recombinant Human EphA2/ECK Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln25-Asn534) of human EphA2 (Accession #NP_004422.2) fused with a 6×His tag at the C-terminus. |
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Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized Human EphA2 at 1 μg/mL (100 μL/well) can bind Human EFNA1 with a linear range of 0.098-4.084 ng/mL. |
Molecular Mass : | 70 kDa |
Protein Length : | Gln25-Asn534 |
Endotoxin : | < 0.1 EU/μg of the protein by LAL method. |
Purity : | > 97% by SDS-PAGE. |
Storage : | Store the lyophilized protein at -20°C to -80 °C for long term. After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week. |
Reconstitution : | Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. |
Gene Name : | EPHA2 EPH receptor A2 [ Homo sapiens ] |
Official Symbol : | EPHA2 |
Synonyms : | EPHA2; EPH receptor A2; ECK, EphA2; ephrin type-A receptor 2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; epithelial cell receptor protein tyrosine kinase; ECK; CTPA; ARCC2; CTPP1; |
Gene ID : | 1969 |
mRNA Refseq : | NM_004431 |
Protein Refseq : | NP_004422 |
MIM : | 176946 |
UniProt ID : | P29317 |
Products Types
◆ Recombinant Protein | ||
Epha2-954M | Recombinant Mouse Epha2 Protein, MYC/DDK-tagged | +Inquiry |
EPHA2-0986H | Recombinant Human EPHA2 Protein (R561-I976), GST tagged | +Inquiry |
Epha2-914M | Active Recombinant Mouse Epha2 protein(Met1-Asn535), His-tagged | +Inquiry |
EPHA2-1308R | Recombinant Rhesus Macaque EPHA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
EPHA2-2515H | Recombinant Human EPHA2 Protein (28-328 aa), His-Myc-tagged | +Inquiry |
◆ Lysates | ||
EPHA2-001HCL | Recombinant Human EPHA2 cell lysate | +Inquiry |
EPHA2-2138MCL | Recombinant Mouse EPHA2 cell lysate | +Inquiry |
EPHA2-1072HCL | Recombinant Human EPHA2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0326 | EphA2 Kinase (Human) Assay/Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe protein has low cytotoxicity.
EPHA2 has good stability, and the test results of heat resistance, acid and alkali resistance and protease degradation resistance are good.
Kinetic parameters such as enzymatic reaction rate and binding affinity were tested, and the protein performed well.
Q&As (6)
Ask a questionTherapeutic strategies for EPHA2 include inhibition of its expression, blocking its signal transduction pathway, and modulating its interaction with ligands. These strategies may involve the use of small molecule inhibitors, antibodies, or other types of therapeutics.
The expression level of EPHA2 is associated with the occurrence and progression of a variety of diseases. For example, in tumors such as lung, breast, and colorectal cancer, EPHA2 expression levels may be elevated and correlated with the degree of malignancy and poor prognosis of the tumor.
In some tumors, EPHA2 expression levels are associated with poor prognosis in patients. For example, patients with lung cancer who express EPHA2 often have shorter survival. Therefore, the expression level of EPHA2 may be one of the indicators to predict tumor prognosis.
Some diseases can be diagnosed by measuring EPHA2 expression levels, such as immunohistochemistry, western blotting, and real-time PCR.
Yes, EPHA2 can be used as a target for the treatment of certain diseases. For example, inhibition of EPHA2 expression can inhibit tumor growth and spread, so EPHA2 can serve as a potential therapeutic target. In addition, regulating the expression level of EPHA2 may also be helpful in the treatment of diseases such as the nervous system and cardiovascular system.
EPHA2 can promote cancer metastasis and affect the spread and spread of cancer by regulating processes such as invasion and migration of tumor cells. Therefore, inhibition of EPHA2 expression or blocking its signal transduction pathway may have a potential therapeutic effect on inhibiting cancer metastasis.
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