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Official Full Name estrogen receptor 1
Background This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
Synonyms ESR1; estrogen receptor 1; ER; ESR; Era; ESRA; ESTRR; NR3A1; estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; nuclear receptor subfamily 3 group A member 1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Insects cell
    • Mammalian Cell
    • S.frugiperda
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ESR1-02H Recombinant Human ESR1 Protein, His-tagged E. coli His
    Human ESR1-014H Recombinant Human ESR1 Protein E.coli
    Human ESR1-01H Recombinant Human Estrogen Receptor 1, His-tagged E. coli His
    Human ESR1-102H Recombinant Human Estrogen alpha receptor LBD/Hsp90 complex, GST-tagged Sf9 Insect Cell GST
    Human ESR1-1033H Recombinant Human Estrogen Receptor 1 Sf9 Insect Cell N/A
    Human ESR1-116H Recombinant Human Estrogen Receptor 1 E.coli N/A
    Human ESR1-117H Recombinant Human ESR1, His-tagged E.coli N/A
    Human ESR1-118H Recombinant Human ESR1 protein, His-tagged E.coli His
    Human ESR1-121H Recombinant Human ESR1, GST-tagged Sf9 Insect Cell GST
    Human ESR1-1250H Recombinant Human ESR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ESR1-12557H Recombinant Human ESR1, GST-tagged E.coli GST
    Human ESR1-1390H Recombinant Human ESR1 Protein (10-595 aa), His-tagged Yeast His
    Human ESR1-227H Recombinant Human ESR1, StrepII-tagged Human Cell Strep II
    Human ESR1-2416H Recombinant Human ESR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ESR1-24H Recombinant Human ESR1 Protein Insects cell N/A
    Human ESR1-2639H Recombinant Human Estrogen Receptor 1 S.frugiperda N/A
    Human ESR1-27977TH Recombinant Human ESR1, His-tagged Insect Cell His
    Human ESR1-28401TH Recombinant Human ESR1 protein E.coli N/A
    Human ESR1-28402TH Recombinant Human ESR1 protein, His-tagged E.coli His
    Human ESR1-3504H Recombinant Human ESR1 Protein, GST-tagged Wheat Germ GST
    Human ESR1-356H Recombinant Human ESR1 protein, His/MBP-tagged E.coli His/MBP
    Human ESR1-4217H Recombinant Human ESR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ESR1-6540HCL Recombinant Human ESR1 293 Cell Lysate HEK293 N/A
    Human ESR1-784H Recombinant Human ESR1 Protein, His-tagged E.coli His
    Human ESR1-8487H Recombinant Human ESR1, His-tagged Sf21 Insect Cell His
    Mouse Esr1-1438M Recombinant Mouse Esr1 protein, His & GST-tagged E.coli His/GST
    Mouse Esr1-977M Recombinant Mouse Esr1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat Esr1-1439R Recombinant Rat Esr1 protein, His & GST-tagged E.coli His/GST
    Rat ESR1-2151R Recombinant Rat ESR1 Protein Mammalian Cell His
    Chicken ESR1-6738C Recombinant Chicken ESR1 Mammalian Cell His
    Zebrafish ESR1-9425Z Recombinant Zebrafish ESR1 Mammalian Cell His

    ESR1 involved in several pathways and played different roles in them. We selected most pathways ESR1 participated on our site, such as Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ESR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Estrogen signaling pathway KCNJ6; PIK3CB; CREB5; CREB3L2; HSPA2; PRKACG; ATF4; MAP2K2; AKT2; KCNJ5
    Prolactin signaling pathway INS; SHC3; NFKB1; SOCS3; SHC1; INS1; PIK3R1; SOCS4; MAP2K2; MAPK13
    Thyroid hormone signaling pathway MED12; PFKP; PLCD4; ESR1; MED12L; PFKFB2; SLC16A2; MDM2; ATP1B3; RCAN2
    Endocrine and other factor-regulated calcium reabsorption ATP1B2; KLK1B22; PLCB3; ATP1A3; GNAS; KLK1B8; ESR1; ATP2B1; KLK1B9; PRKCA
    Proteoglycans in cancer SLC9A1; VEGFA; TP53; MAPK13; SOS1; MAPK12; ARHGEF1; PIK3R1; TIMP3; CBLB

    ESR1 has several biochemical functions, for example, ATPase binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ESR1 itself. We selected most functions ESR1 had, and list some proteins which have the same functions with ESR1. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding RALB; ATP6V0A1; CAV1; ATP6V0A1B; ATP6V0A2; FXYD7; NR1H2; FBL; DRD1; SNTA1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding RFX4; CEBPG; TBX20; CHD7; BCL11B; NEUROD6; NEUROD1; MYF5; SMAD3; MYB
    RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR2A; ESR1; ESR2B
    beta-catenin binding SLC9A3R2; PSEN1; PARK2; TCF7L1B; FAM123B; BCL9; TCF7L1A; PROP1; NF2; HDAC6
    chromatin binding PPARG; SMC3; EZH1; CHD7; SSRP1; NFKB2; NCAPD2; SIRT7; MB21D2; HOXC13
    core promoter sequence-specific DNA binding SOX9; NFYA; SOHLH1; CREM; TRP53; NR1D1; SOX4; CRY1; CHD2; MTA1
    enzyme binding LYN; KRT79; ZNHIT6; KDM1A; BCL10; GSTM7; NCOA1; MDM4; PUS7; ATP2A2
    estrogen receptor activity ESR2; GPR30; ESR1; LEF1; NKX3; ESR2A; ESR2B; NKX3-1
    estrogen response element binding ESR1; TRIM24; TOX3; ESR2
    identical protein binding BAK1; DNM1; HACL1; TPRG1L; TNPO3; S100B; ACY3; PPPDE2; TRP53; PRPS2
    nitric-oxide synthase regulator activity CALM1; AKT1; ESR1; HSP90AB1; CALM3; CALM2; HSP90AA1; HSP90AA1.1
    protein binding STAG1; CD300LD; COMMD7; TCF7L2; HSPB6; ZNF593; RTN4RL2A; LRCH3; NOP56; TMEM194
    steroid binding CYP21A1; PDIA2; AKR1D1; ESRRB; PAQR7B; PAQR5A; ESRRG; HSD17B10; GPR30; PAQR5
    steroid hormone receptor activity NR1H2; RXRAB; RXRGB; NR1D4B; NR5A5; RORCA; RORAA; NR6A1A; NR5A1A; PPARG
    transcription factor activity, sequence-specific DNA binding ZFP82; USF2; E2F3; SMAD1; TBX16; E2F7; GLI3; SALL4; ZNF263; SOX11
    transcription factor binding KLF5; GCM1; CD34; MYOD1; PPP1R13L; HMGA1-RS1; HTT; RARA; SNF8; TAF12
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding MYB; NEUROD6; SPI1; SREBF1; HNF1A; DLX3; ONECUT2; SMAD1; NR6A1; NR2E1
    zinc ion binding PTPN1; RBX1; ANPEP; ADAMTS2; TET2; CSRP1B; LIN28A; NPLOC4; PIAS4; VPS29

    ESR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ESR1.

    NCOA1; DDX5

    Yu, T; Zhou, ZC; et al. A novel anti-cancer agent, acetyltanshinone IIA, inhibits oestrogen receptor positive breast cancer cell growth by down-regulating the oestrogen receptor. CANCER LETTERS 346:94-103(2014).
    Pogue-Geile, KL; Kim, C; et al. Predicting Degree of Benefit From Adjuvant Trastuzumab in NSABP Trial B-31. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1782-1788(2013).

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