|Official Full Name||exostosin 2|
|Background||EXT2 is one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses.|
|Synonyms||EXT2; exostosin 2; exostoses (multiple) 2; exostosin-2; Glucuronosyl N acetylglucosaminyl proteoglycan 4 alpha N acetylglucosaminyltransferase; N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase; SOTV; multiple exostoses protein 2; putative tumor suppressor protein EXT2; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ext2 involved in several pathways and played different roles in them. We selected most pathways ext2 participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ext2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Glycosaminoglycan biosynthesis - heparan sulfate / heparin||XYLT2; MAPK1IP1L; HS3ST3A1; EXTL1; HS6ST1A; NDST1; EXT2; EXT1; EXT1B; HS2ST1A|
|Metabolic pathways||GMPPA; ALOX8; GRHPR; SDHB; CMAS; ATP6V1B1; POLG2; DNMT3A; FUK; LPIN1|
ext2 has several biochemical functions, for example, N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity, contributes_to acetylglucosaminyltransferase activity, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ext2 itself. We selected most functions ext2 had, and list some proteins which have the same functions with ext2. You can find most of the proteins on our site.
|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity||EXT1A; EXT1; EXT2; EXT1B; EXT1C|
|contributes_to acetylglucosaminyltransferase activity||EXT2|
|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity||EXT1B; EXT1; EXT2; EXT1C; EXTL1; EXT1A|
|glucuronosyltransferase activity||UGT1A2; UGT5B3; UGT5D1; B3GNT1; UGT5E1; GYLTL1B; UGT8; UGT2A4; UGT5B2; UGT1AB|
|heparan sulfate N-acetylglucosaminyltransferase activity||EXT2; EXT1|
|metal ion binding||CAR13; OVOL2; ZUFSP; ZNF577; CSRP1A; SCRT1; COL27A1A; CHSY1; BMPR1BB; TDO2|
|protein heterodimerization activity||USF2; GCLC; H2-AA; Defa-rs7; MYOG; ADORA2A; BIRC5; TAS1R2; MAPK6; TCF12|
|NOT protein homodimerization activity||KCNA3; MLXIPL; DDIT3; MECOM; EXT2; MSH3; MSH6; MYO9B; NUDT16L1|
|transferase activity, transferring glycosyl groups||ST3GAL3B; POMGNT2; UGT1A7C; UGT1AB; MGAT4C; B3GAT1A; DPY19L4; GYG1A; UGT2B5; PNP4B|
ext2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ext2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ext2.
STK16; SNCG; FABP4; CNTF; HNF4A; RPS29; CRB1; TCEB1; HYOU1; SLC22A2; PFDN1; TK1; ANXA7; CDKN1A; SMN1; yapA; GSKIP