ext2 Protein, exostosin 2


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Official Full Name exostosin 2
Background EXT2 is one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses.
Synonyms EXT2; exostosin 2; exostoses (multiple) 2; exostosin-2; Glucuronosyl N acetylglucosaminyl proteoglycan 4 alpha N acetylglucosaminyltransferase; N acetylglucosaminyl proteoglycan 4 beta glucuronosyltransferase; SOTV; multiple exostoses protein 2; putative tumor suppressor protein EXT2; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EXT2-12604H Recombinant Human EXT2, GST-tagged E.coli GST
    Human EXT2-3585H Recombinant Human EXT2 Protein, GST-tagged Wheat Germ GST
    Human EXT2-6496HCL Recombinant Human EXT2 293 Cell Lysate HEK293 N/A
    Mouse EXT2-5392M Recombinant Mouse EXT2 Protein Mammalian Cell His
    Chicken EXT2-3003C Recombinant Chicken EXT2 Mammalian Cell His
    Zebrafish EXT2-1866Z Recombinant Zebrafish EXT2 Mammalian Cell His

    ext2 involved in several pathways and played different roles in them. We selected most pathways ext2 participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ext2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin XYLT2; MAPK1IP1L; HS3ST3A1; EXTL1; HS6ST1A; NDST1; EXT2; EXT1; EXT1B; HS2ST1A
    Metabolic pathways GMPPA; ALOX8; GRHPR; SDHB; CMAS; ATP6V1B1; POLG2; DNMT3A; FUK; LPIN1

    ext2 has several biochemical functions, for example, N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity, contributes_to acetylglucosaminyltransferase activity, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ext2 itself. We selected most functions ext2 had, and list some proteins which have the same functions with ext2. You can find most of the proteins on our site.

    Function Related Protein
    N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity EXT1A; EXT1; EXT2; EXT1B; EXT1C
    contributes_to acetylglucosaminyltransferase activity EXT2
    glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity EXT1B; EXT1; EXT2; EXT1C; EXTL1; EXT1A
    glucuronosyltransferase activity UGT1A2; UGT5B3; UGT5D1; B3GNT1; UGT5E1; GYLTL1B; UGT8; UGT2A4; UGT5B2; UGT1AB
    heparan sulfate N-acetylglucosaminyltransferase activity EXT2; EXT1
    metal ion binding CAR13; OVOL2; ZUFSP; ZNF577; CSRP1A; SCRT1; COL27A1A; CHSY1; BMPR1BB; TDO2
    protein heterodimerization activity USF2; GCLC; H2-AA; Defa-rs7; MYOG; ADORA2A; BIRC5; TAS1R2; MAPK6; TCF12
    NOT protein homodimerization activity KCNA3; MLXIPL; DDIT3; MECOM; EXT2; MSH3; MSH6; MYO9B; NUDT16L1
    transferase activity, transferring glycosyl groups ST3GAL3B; POMGNT2; UGT1A7C; UGT1AB; MGAT4C; B3GAT1A; DPY19L4; GYG1A; UGT2B5; PNP4B

    ext2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ext2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ext2.


    Nadanaka, S; Kagiyama, S; et al. Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes. BIOCHEMICAL JOURNAL 454:133-145(2013).
    Multhaupt, HAB; Couchman, JR; et al. Heparan Sulfate Biosynthesis: Methods for Investigation of the Heparanosome. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 60:908-915(2012).

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