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FANCF

Official Full Name

Fanconi anemia, complementation group F
Overview

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008]
Synonyms

FANCF; Fanconi anemia, complementation group F; FAF; Fanconi anemia group F protein;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FANCF-3831H	Recombinant Human FANCF Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FANCF-28386TH	Recombinant Human FANCF	Wheat Germ	N/A	91 amino acids	Inquiry
Human	FANCF-6332HCL	Recombinant Human FANCF 293 Cell Lysate	HEK293	N/A		Inquiry
Human	FANCF-4666HF	Recombinant Full Length Human FANCF Protein, GST-tagged	In Vitro Cell Free System	GST	374 amino acids	Inquiry
Zebrafish	FANCF-4248Z	Recombinant Zebrafish FANCF	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FANCF Related Articles

FANCF involved in several pathways and played different roles in them. We selected most pathways FANCF participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Fanconi anemia pathway	RPA1;FAN1;FANCM;CDK5R2;SLX4;C19orf40;USP36;FANCE;FANCA

FANCF has several biochemical functions, for example, molecular_function, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCF itself. We selected most functions FANCF had, and list some proteins which have the same functions with FANCF. You can find most of the proteins on our site.

Function	Related Protein
molecular_function	Ajap1;CLASRP;PODNL1;TAS2R124;TEX264A;CHMP5B;JPH4;IQCJ;TNNI1C
protein binding	ERCC6L;OSBPL6;SMURF1;CYCS;FOXN3;PHAX;CLEC7A;CD3E;PCGF5
ubiquitin protein ligase activity	RNF181;CCNB1IP1;RNF6;HERC4;HERC6;ARIH2;TRIM71;MSL2A;HUWE1

FANCF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCF here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCF.

FANCG; FANCA; SPTAN1; Hacd3; PPP5C; OLFM2; MARK3; aguA; FANCE

Synowiec, A; Szenajch, J; et al. The role of the Fanconi anemia pathway in the pathophysiology of ovarian cancer. GINEKOLOGIA POLSKA 86:150-154(2015).

Arai, MA; Uemura, K; et al. Naturally occurring FANCF-Hes1 complex inhibitors from Wrightia religiosa. MEDCHEMCOMM 6:455-460(2015).