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FANCI

Official Full Name

Fanconi anemia, complementation group I
Overview

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms.
Synonyms

FANCI; Fanconi anemia, complementation group I; KIAA1794; Fanconi anemia group I protein; FLJ10719; FLJ14658; Protein FANCI;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FANCI-12740H	Recombinant Human FANCI, GST-tagged	E.coli	GST	1-252a.a.	$319 / 25ug
Human	FANCI-627HCL	Recombinant Human FANCI cell lysate		N/A		Inquiry
Human	FANCI-4220H	Recombinant Human FANCI Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FANCI-4844HF	Recombinant Full Length Human FANCI Protein, GST-tagged	In Vitro Cell Free System	GST	73 amino acids	Inquiry
Human	FANCI-0404H	Recombinant Human FANCI protein, His-tagged	E.coli	His	1-252 aa	$319 / 25ug
Mouse	FANCI-5673M	Recombinant Mouse FANCI Protein	Mammalian Cell	His		Inquiry
Mouse	FANCI-3111M-B	Recombinant Mouse FANCI Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	FANCI-3111M	Recombinant Mouse FANCI Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	FANCI-4675Z	Recombinant Zebrafish FANCI	Mammalian Cell	His		Inquiry
Chicken	FANCI-3824C	Recombinant Chicken FANCI	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FANCI Related Articles

FANCI involved in several pathways and played different roles in them. We selected most pathways FANCI participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FANCI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Fanconi anemia pathway	STRA13;FANCE;RPA4;FANCB;MUS81;HER9;TOP3B;BRIP1;RAD51

FANCI has several biochemical functions, for example, DNA binding, DNA polymerase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FANCI itself. We selected most functions FANCI had, and list some proteins which have the same functions with FANCI. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	GTF3A;ZBTB20;MTF2;ZNF334;DACH2;HNRNPU;BLM;ZBTB5;RARB
DNA polymerase binding	SMARCA4;RAD51;FANCI;PCNA;HMGB1;FANCD2;LONP1;CDK2AP1;ACD
protein binding	QARS;TNPO3;FOXG1;JUB;EEF1B2;TACR3;C22orf39;BBS13;FAM118A

FANCI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FANCI here. Most of them are supplied by our site. Hope this information will be useful for your research of FANCI.

FANCD2; ILK; FSCN1; PRKAB2; PTP4A3; MYC; TNFRSF1A; TNFRSF1B; CLN3; TSC22D1; CAMKK2; C20orf24; BRF2; NEK6; USP36; GSTK1

Raghunandan, M; Chaudhury, I; et al. FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex. CELL CYCLE 14:342-353(2015).

Gibbs-Seymour, I; Oka, Y; et al. Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage. MOLECULAR CELL 57:150-164(2015).