FASTK
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Official Full Name
Fas-activated serine/threonine kinase
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Overview
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. -
Synonyms
FASTK; Fas-activated serine/threonine kinase; FAST; Fas activated serine threonine kinase; Fas activated serine threonine kinase isoform 1; Fas activated serine threonine kinase isoform 4; FAST kinase; FLJ13079;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- GST
- His
- Myc
- DDK
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- FASTK Related Articles
FASTK involved in several pathways and played different roles in them. We selected most pathways FASTK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FASTK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
FASTK has several biochemical functions, for example, ATP binding, Fas-activated serine/threonine kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FASTK itself. We selected most functions FASTK had, and list some proteins which have the same functions with FASTK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CSNK2A2;ACSL4;CDK4;MARS2;ULK4;IDH3G;RENBP;MARK1;Aatk |
| Fas-activated serine/threonine kinase activity | |
| protein binding | COL23A1;EIF4ENIF1;UBTD1;FAM86C;ERP29;CD8A;RAD18;MYO1E;SNAP29 |
| protein serine/threonine kinase activity | MAP3K13;CAMK1DA;AKT3;STK4;MAPK6;ULK1A;MAP2K6;SGK1;GSK3B |
FASTK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FASTK here. Most of them are supplied by our site. Hope this information will be useful for your research of FASTK.
WIPF1; TNKS2; HSP90AB1; CRK
- Q&As
- Reviews
Q&As (5)
Ask a questionFASTK is a key protein regulating mitochondrial respiration, and knockdown of FASTK leads to mitochondrial respiratory dysfunction and apoptosis.
HBc proteins downregulate FASTK transcription and expression by repressing promoter activity.
FASTK interacts with the RNA-binding protein TIA1.
FASTK protein is localized to mitochondria.
FASTK functions in protein amino acid phosphorylation, apoptosis, signal transduction and extracellular signaling to guide apoptosis.
Customer Reviews (2)
Write a reviewProtein products are put into experiments with good effect and reliable experimental results.
The technical staff evaluated my experimental process and results and made many constructive comments.
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