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FBXL2

  • Official Full Name

    F-box and leucine-rich repeat protein 2

  • Overview

    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    FBXL2; F-box and leucine-rich repeat protein 2; F-box/LRR-repeat protein 2; FBL2; FBL3; DKFZP564P0622; F box and leucine rich repeat protein 2; F-box protein containing leucine-rich repeats; F-box protein FBL2/FBL3; FBL 2; FBL 3; FBXL 2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FBXL2-3898H Recombinant Human FBXL2 Protein, GST-tagged Wheat Germ GST
Human FBXL2-4964HF Recombinant Full Length Human FBXL2 Protein, GST-tagged In Vitro Cell Free System GST 423 amino acids
Human FBXL2-895H-B Recombinant Human FBXL2 Protein Pre-coupled Magnetic Beads HEK293
Human FBXL2-895H Recombinant Human FBXL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FBXL2-1159H Recombinant Human FBXL2 Protein (1-423 aa), His-SUMO-tagged E.coli His/SUMO 1-423 aa
Human FBXL2-961HFL Recombinant Full Length Human FBXL2 Protein, C-Flag-tagged Mammalian cells Flag
Human FBXL2-2298H Recombinant Human FBXL2 Protein (1-423 aa), His-tagged Yeast His 1-423 aa
Human FBXL2-3779H Recombinant Human FBXL2 protein, His-tagged E.coli His 341 - 423 aa
Mouse Fbxl2-2962M Recombinant Mouse Fbxl2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish FBXL2-10458Z Recombinant Zebrafish FBXL2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FBXL2 Related Articles

FBXL2 involved in several pathways and played different roles in them. We selected most pathways FBXL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBXL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

FBXL2 has several biochemical functions, for example, contributes_to ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FBXL2 itself. We selected most functions FBXL2 had, and list some proteins which have the same functions with FBXL2. You can find most of the proteins on our site.

Function Related Protein
contributes_to ubiquitin protein ligase activityFBXL6;FBXL14A;C10orf46;CUL4A;FBXL7;FBXL15;FBXL2;FBXL3;CUL1A

FBXL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBXL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBXL2.

Salamon, S; Nowacka-Woszuk, J; et al. A Lack of Association between Polymorphisms of Three Positional Candidate Genes (CLASP2, UBP1, and FBXL2) and Canine Disorder of Sexual Development (78,XX; SRY-Negative). SEXUAL DEVELOPMENT 8:160-165(2014).
Mallampalli, RK; Coon, TA; et al. Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation. JOURNAL OF IMMUNOLOGY 191:5247-5255(2013).
  • Q&As
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