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Official Full Name ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)
Background Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.
Synonyms FCN3; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen); ficolin-3; FCNH; HAKA1; Collagen/fibrinogen domain containing lectin 3 p35; Collagen/fibrinogen domain containing protein 3; FCN 3; Ficolin (collagen/fibrinogen domain containing) 3; Ficolin 3; H ficolin; Hakata antigen; MGC22543; H-ficolin; OTTHUMP00000006338; OTTHUMP00000006339; collagen/fibrinogen domain-containing protein 3; collagen/fibrinogen domain-containing lectin 3 p35
    • Species :
    • Human
    • Source :
    • E.coli
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FCN3-12827H Recombinant Human FCN3, GST-tagged E.coli GST
    Human FCN3-1949H Recombinant Human FCN3 protein, His-tagged E.coli His
    Human FCN3-4004H Recombinant Human FCN3 Protein, GST-tagged Wheat Germ GST
    Human FCN3-614HCL Recombinant Human FCN3 cell lysate N/A
    Human FCN3-854H Recombinant Human FCN3 Protein, His-tagged Mammalian cells His

    fcn3 involved in several pathways and played different roles in them. We selected most pathways fcn3 participated on our site, such as Complement cascade, Creation of C4 and C2 activators, Ficolins bind to repetitive carbohydrate structures on the target cell surface, which may be useful for your reference. Also, other proteins which involved in the same pathway with fcn3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement cascade FCN3; CR1; IGKC; BFB; FCN1; RCA2.1; IGKV1-5; CRP; HBL3; GZMM
    Creation of C4 and C2 activators IGKC; FCN3; FCN1; CRP; C1rb; IgG3; IGLC2; HBL3; FCN2; IGKV1-5
    Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN2; MASP2; FCN3; FCN1
    Initial triggering of complement FCN2; C1rb; HBL3; BFB; FCN1; CFD; IgG3; CRP; MASP2; GZMM
    Innate Immune System ABI2; BTR30; S100A12; CRP; MGC174155; KIR3DS1; TANK; TREM1; RIPK3; DEFB116
    Lectin pathway of complement activation FCN2; FCN3; FCN1; HBL3

    fcn3 has several biochemical functions, for example, antigen binding, carbohydrate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by fcn3 itself. We selected most functions fcn3 had, and list some proteins which have the same functions with fcn3. You can find most of the proteins on our site.

    Function Related Protein
    antigen binding Ighg2a; IGLC2; IGKV1-5; MHC1UKA; TSPAN4; HNRNPM; LILRA1; TOPORS; LILRB4; IGKC
    carbohydrate binding CD302; GALNT7; CD93; GALNT4; CD72; REG3B; CD55; CLEC5A; CLEC7A; PKD1
    protein binding PAX9; SCNM1; ZC3H8; TXN2; WRN; CLUAP1; KLHL18; EGLN2; DGKQ; GPC3

    fcn3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with fcn3 here. Most of them are supplied by our site. Hope this information will be useful for your research of fcn3.

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