Active Recombinant Human FGF12 Protein

• Cat.No.: FGF12-026H
• Product Overview: The mature recombinant human FGF-12 protein consists of 181 amino acids (1-181) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 1-181 a.a.
• Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined.
• Bio-activity: Measured by its binding ability in a functional ELISA. Immobilized rhFGF R4/Fc Chimera at 5 μg/mL (100 μL/well) can bind rhFGF-12 with a linear range of 1.6-100 ng/mL.
• Molecular Mass: 22.4 kDa
• Product-Related Proteins: 1-181
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: FGF12 fibroblast growth factor 12 [ Homo sapiens (human) ]
• Official Symbol: FGF12
• Synonyms: FGF12; fibroblast growth factor 12; FHF1; DEE47; EIEE47; FGF12B; fibroblast growth factor 12; Names; fibroblast growth factor 12B; fibroblast growth factor FGF-12b; fibroblast growth factor homologous factor 1; myocyte-activating factor
• Gene ID: 2257
• mRNA Refseq: NM_021032
• Protein Refseq: NP_066360
• MIM: 601513
• UniProt ID: P61328