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Active Recombinant Human FGF18 Protein (Ala27-Arg199), C-His tagged, Animal-free, Carrier-free

Cat.No. : FGF18-308H
Product Overview : Recombinant Human FGF18 Protein (Ala27-Arg199) with C-His tag was expressed in E. coli and Animal-free as well as Carrier-free.
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Description : Fibroblast Growth Factors-18 (FGF-18) is a 24 kDa member of the fibroblast Growth Factors with 207 amino acid residues. FGF-18 is mainly expressed from glandular and luminal cells, cardiomyocytes, breast myoepithelial cells and endometrial ciliated cells. FGF-18 involved cell proliferation, cell differentiation and cell migration. FGF-18 is an important role in skeletal growth and development, stimulates hepatic and intestinal proliferation.
Source : E. coli
Species : Human
Tag : C-His
Form : Lyophilized
Bio-activity : Measure by its ability to induce 3T3 cells proliferation. The ED50 for this effect is 1.3-2.0 ng/mL. The specific activity of recombinant human FGF-18 is > 5 × 10⁵ IU/mg.
Molecular Mass : The protein has a calculated MW of 21.11 kDa.
The protein migrates as 20 kDa under reducing condition (SDS-PAGE analysis).
Protein Length : Ala27-Arg199
Endotoxin : < 0.1 EU/μg of the protein by the LAL method.
Purity : >98% as determined by SDS-PAGE analysis.
Storage : This product is stable after storage at:
-20 centigrade for 12 months in lyophilized state from date of receipt.
-20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
Avoid repeated freeze/thaw cycles.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0.
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Shipping : The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.
Gene Name : FGF18 fibroblast growth factor 18 [ Homo sapiens (human) ]
Official Symbol : FGF18
Synonyms : FGF18; fibroblast growth factor 18; FGF 18; ZFGF5; FGF-18;
Gene ID : 8817
mRNA Refseq : NM_003862
Protein Refseq : NP_003853
MIM : 603726
UniProt ID : O76093

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential side effects of FGF18 therapy? 12/04/2021

While generally considered safe, potential side effects may include local reactions at the injection site. Comprehensive studies are ongoing to assess long-term safety.

Is FGF18 only applicable to bone-related conditions? 05/04/2021

While its primary focus is on musculoskeletal conditions, FGF18's role in cellular growth and repair suggests potential applications in other medical fields.

How does FGF18 compare to other growth factors in terms of clinical applications? 07/03/2020

Comparative studies are underway to evaluate the effectiveness and safety of FGF18 against other growth factors in various clinical scenarios.

Are there any ongoing clinical trials involving FGF18? 12/22/2019

Yes, there are several clinical trials exploring the safety and efficacy of FGF18 in various musculoskeletal disorders and conditions.

How does FGF18 contribute to the treatment of osteoarthritis? 07/08/2017

FGF18 has shown promise in promoting cartilage repair and regeneration, making it a potential candidate for the development of therapies for osteoarthritis.

Customer Reviews (3)

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Reviews
01/09/2022

    the FGF18 protein exhibits remarkable stability, enabling it to maintain its structural integrity and functionality throughout the experimental process.

    05/30/2021

      The FGF18 protein offers exceptional quality and purity, which is crucial for ensuring reliable and reproducible experimental outcomes.

      12/08/2017

        As a researcher utilizing the FGF18 protein, I am fortunate to benefit from its numerous advantages in trials.

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