Active Recombinant Human Fibroblast Growth Factor 18, HIgG1 Fc-tagged, mutant
Cat.No. : | FGF18-222H |
Product Overview : | The extracellular domain of human FGF-18(AAH06245.1)(Glu28-Ala207) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures |
Source : | CHO cell |
Species : | Human |
Tag : | HIgG1 Fc-tagged, mutant |
Form : | Lyophilized from 0.2 μm-filtered solution in PBS. |
Bio-activity : | Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. |
Molecular Mass : | 47KDa (monomer) |
AA Sequence : | Glu28-Ala207 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100 μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | FGF18 fibroblast growth factor 18 [ Homo sapiens ] |
Official Symbol : | FGF18 |
Synonyms : | FGF18; fibroblast growth factor 18; FGF 18; ZFGF5; FGF-18; |
Gene ID : | 8817 |
mRNA Refseq : | NM_003862 |
Protein Refseq : | NP_003853 |
MIM : | 603726 |
UniProt ID : | O76093 |
Chromosome Location : | 5q34 |
Pathway : | Downstream signaling of activated FGFR, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR2 ligand binding and activation, organism-specific biosystem; FGFR2c ligand binding and activation, organism-specific biosystem; FGFR3 ligand binding and activation, organism-specific biosystem; FGFR3b ligand binding and activation, organism-specific biosystem; |
Function : | growth factor activity; protein tyrosine kinase activity; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding; |
Products Types
◆ Recombinant Protein | ||
FGF18-1483H | Recombinant Human FGF18 Protein, His-tagged | +Inquiry |
FGF18-2946H | Recombinant Human FGF18 Protein, His (Fc)-Avi-tagged | +Inquiry |
FGF18-1987R | Recombinant Rat FGF18 Protein, His (Fc)-Avi-tagged | +Inquiry |
Fgf18-417F | Active Recombinant Mouse Fgf18 Protein (172 aa) | +Inquiry |
FGF18-308H | Active Recombinant Human FGF18 Protein (Ala27-Arg199), C-His tagged, Animal-free, Carrier-free | +Inquiry |
◆ Lysates | ||
FGF18-2430MCL | Recombinant Mouse FGF18 cell lysate | +Inquiry |
FGF18-1660HCL | Recombinant Human FGF18 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionWhile generally considered safe, potential side effects may include local reactions at the injection site. Comprehensive studies are ongoing to assess long-term safety.
While its primary focus is on musculoskeletal conditions, FGF18's role in cellular growth and repair suggests potential applications in other medical fields.
Comparative studies are underway to evaluate the effectiveness and safety of FGF18 against other growth factors in various clinical scenarios.
Yes, there are several clinical trials exploring the safety and efficacy of FGF18 in various musculoskeletal disorders and conditions.
FGF18 has shown promise in promoting cartilage repair and regeneration, making it a potential candidate for the development of therapies for osteoarthritis.
Customer Reviews (3)
Write a reviewthe FGF18 protein exhibits remarkable stability, enabling it to maintain its structural integrity and functionality throughout the experimental process.
The FGF18 protein offers exceptional quality and purity, which is crucial for ensuring reliable and reproducible experimental outcomes.
As a researcher utilizing the FGF18 protein, I am fortunate to benefit from its numerous advantages in trials.
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