Recombinant Human FGF18 Protein (28-207), N-hFc-tagged

Cat.No. : FGF18-12H
Product Overview : Recombinant human FGF-18 protein (aa 28-207) fused to the N-terminus of the Fc region of human IgG1 was expressed in HEK293.
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Description : The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.
Source : HEK293
Species : Human
Tag : N-hFc
Molecular Mass : ~60 kDa (SDS-PAGE)
Protein Length : 28-207
Endotoxin : <5 EU/mg purified protein (LAL test; Lonza).
Purity : ≥ 98% (SDS-PAGE)
Stability : Stable for at least 1 year after receipt when stored at -20 centigrade.
Working aliquots are stable for up to 3 months when stored at -20 centigrade.
Storage : Short Term Storage: +4 centigrade
Long Term Storage: -20 centigrade
Storage Buffer : Lyophilized from 0.2 μm-filtered solution in PBS.
Reconstitution : Reconstitute 50 μg vial in 50 μL sterile water to a concentration of 1 mg/mL.
Add 1 × PBS to the desired protein concentration.
Handling : After opening, prepare aliquots and store at -20 centigrade.
Avoid freeze/thaw cycles.
Centrifuge lyophilized vial before opening and reconstitution.
Shipping : BLUE ICE
Gene Name : FGF18 fibroblast growth factor 18 [ Homo sapiens (human) ]
Official Symbol : FGF18
Synonyms : FGF18; fibroblast growth factor 18; ZFGF5; FGF-18; fibroblast growth factor 18
Gene ID : 8817
mRNA Refseq : NM_003862.3
Protein Refseq : NP_003853.1
MIM : 603726
UniProt ID : O76093

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential side effects of FGF18 therapy? 12/04/2021

While generally considered safe, potential side effects may include local reactions at the injection site. Comprehensive studies are ongoing to assess long-term safety.

Is FGF18 only applicable to bone-related conditions? 05/04/2021

While its primary focus is on musculoskeletal conditions, FGF18's role in cellular growth and repair suggests potential applications in other medical fields.

How does FGF18 compare to other growth factors in terms of clinical applications? 07/03/2020

Comparative studies are underway to evaluate the effectiveness and safety of FGF18 against other growth factors in various clinical scenarios.

Are there any ongoing clinical trials involving FGF18? 12/22/2019

Yes, there are several clinical trials exploring the safety and efficacy of FGF18 in various musculoskeletal disorders and conditions.

How does FGF18 contribute to the treatment of osteoarthritis? 07/08/2017

FGF18 has shown promise in promoting cartilage repair and regeneration, making it a potential candidate for the development of therapies for osteoarthritis.

Customer Reviews (3)

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Reviews
01/09/2022

    the FGF18 protein exhibits remarkable stability, enabling it to maintain its structural integrity and functionality throughout the experimental process.

    05/30/2021

      The FGF18 protein offers exceptional quality and purity, which is crucial for ensuring reliable and reproducible experimental outcomes.

      12/08/2017

        As a researcher utilizing the FGF18 protein, I am fortunate to benefit from its numerous advantages in trials.

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