FGR

  • Official Full Name

    feline Gardner-Rasheed sarcoma viral oncogene homolog

  • Overview

    This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms

    FGR; feline Gardner-Rasheed sarcoma viral oncogene homolog; SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr; tyrosine-protein kinase Fgr; p55-c-fgr protein; c-fgr protooncogene; proto-oncogene c-Fgr; c-src-2 proto-oncogene; proto-oncogene tyrosine-protein kinase FGR; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FGR-1406H Active Recombinant Human FGR, GST-tagged Sf9 Insect Cell GST Full length
Human FGR-898HFL Active Recombinant Full Length Human FGR Protein, C-Flag-tagged Mammalian cells Flag
Human FGR-87H Active Recombinant Human FGR(2-end) Protein, N-His-tagged Sf21 His 2-end
Human FGR-317H Recombinant Human FGR, GST-tagged, Active Sf9 Insect Cell GST
Human FGR-6228HCL Recombinant Human FGR 293 Cell Lysate HEK293 N/A
Human FGR-4155H Active Recombinant Human FGR Protein, GST/His-tagged Insect Cell GST/His
Human FGR-913H Recombinant Human FGR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FGR-913H-B Recombinant Human FGR Protein Pre-coupled Magnetic Beads HEK293
Human FGR-4948HF Recombinant Full Length Human FGR Protein, GST-tagged In Vitro Cell Free System GST 529 amino acids
Human FGR-4156H Recombinant Human FGR Protein, GST-tagged Wheat Germ GST
Human FGR-0768H Recombinant Human FGR Protein (G2-T529), Tag Free Insect Cell No tag G2-T529
Human FGR-3628HF Active Recombinant Full Length Human FGR Protein, GST-tagged Insect (sf21) GST 1-529
Human FGR-0769H Recombinant Human FGR Protein (G2-T529), GST tagged Insect Cell GST G2-T529
Mouse FGR-5870M Recombinant Mouse FGR Protein Mammalian Cell His
Mouse FGR-3246M-B Recombinant Mouse FGR Protein Pre-coupled Magnetic Beads HEK293
Mouse FGR-3246M Recombinant Mouse FGR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fgr-3008M Recombinant Mouse Fgr Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat FGR-2343R Recombinant Rat FGR Protein Mammalian Cell His
Rat FGR-1999R Recombinant Rat FGR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FGR-1999R-B Recombinant Rat FGR Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FGR-1707R Recombinant Rhesus monkey FGR Protein, His-tagged Mammalian Cell His
Rhesus Macaque FGR-1529R-B Recombinant Rhesus Macaque FGR Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FGR-1529R Recombinant Rhesus Macaque FGR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Kit-1591 FGR Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

FGR involved in several pathways and played different roles in them. We selected most pathways FGR participated on our site, such as Chemokine signaling pathway, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine signaling pathwayPAK1;GM13304;CXCL1;GNGT2;GNG8;BRAF;XCR1;CXCR4;PIK3CD
Epstein-Barr virus infectionIRF3;IFNG;POLR2L;PSMD7;PSMC4;NFKBIB;PRKACG;HLA-DRB5;RAN

FGR has several biochemical functions, for example, ATP binding, Fc-gamma receptor I complex binding, immunoglobulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGR itself. We selected most functions FGR had, and list some proteins which have the same functions with FGR. You can find most of the proteins on our site.

Function Related Protein
ATP bindingHSP90AA1.2;UBE2S;PI4K2B;MAP3K11;RFK;SLC14A2;MAP3K8;DHX35;XRCC3
Fc-gamma receptor I complex bindingFGR;FLNA
immunoglobulin receptor bindingIGLL1;Ighg;IgG3;IGKC;CLEC4D;FGR;FES;IGLC2;Ighg2a
non-membrane spanning protein tyrosine kinase activityTNK1;PRKCD;PTK2AA;PTK6B;CSK;YES1;PTK2BB;FYNA;PTK2B
phosphotyrosine bindingSHC1;ZAP70;CBLB;MAPK3;FGR;CBL;ACP2;STAP1;CBLC
protein bindingNPBWR1;SDC4;APBA2;KLF3;NAB2;TAF2;ADPRH;DST;RNF20
protein kinase bindingMAP2K3;AURKA;PPME1;TEX14;PKD1;TRPV4;TSKS;JAK2;CCNB3
protein tyrosine kinase activityPTK6B;TYRO3;PTK7;EPHA4A;DYRK1A;FYNB;PDGFRB;FYNA;EPHB2B

FGR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGR here. Most of them are supplied by our site. Hope this information will be useful for your research of FGR.

HSP90AB1; EGFR; ERBB2; MET; ALOX5; AR; KIT; WAS; EEF1A2; ABI1; abl-tide

Research Area

Related articles

Abu Shehab, M; Damerill, I; et al. Liver mTOR Controls IGF-I Bioavailability by Regulation of Protein Kinase CK2 and IGFBP-1 Phosphorylation in Fetal Growth Restriction. ENDOCRINOLOGY 155:1327-1339(2014).
Deng, L; Kitova, EN; et al. Mapping Protein-Ligand Interactions in the Gas Phase Using a Functional Group Replacement Strategy. Comparison of CID and BIRD Activation Methods. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 24:988-996(2013).
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