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Official Full Name feline Gardner-Rasheed sarcoma viral oncogene homolog
Background This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Synonyms FGR; feline Gardner-Rasheed sarcoma viral oncogene homolog; SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr; tyrosine-protein kinase Fgr; p55-c-fgr protein; c-fgr protooncogene; proto-oncogene c-Fgr; c-src-2 proto-oncogene; proto-oncogene tyrosine-protein kinase FGR; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FGR-1406H Recombinant Human FGR (Active), GST-tagged Sf9 Insect Cell GST
    Human FGR-317H Recombinant Human FGR, GST-tagged, Active Sf9 Insect Cell GST
    Human FGR-4155H Recombinant Human FGR Protein, GST/His-tagged Insect Cell GST/His
    Human FGR-4156H Recombinant Human FGR Protein, GST-tagged Wheat Germ GST
    Human FGR-6228HCL Recombinant Human FGR 293 Cell Lysate HEK293 N/A
    Mouse Fgr-3008M Recombinant Mouse Fgr Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse FGR-5870M Recombinant Mouse FGR Protein Mammalian Cell His
    Rat FGR-2343R Recombinant Rat FGR Protein Mammalian Cell His
    Rhesus Macaque FGR-1707R Recombinant Rhesus monkey FGR Protein, His-tagged Mammalian Cell His
    Kit-1591 FGR Activity Assay Kit N/A

    fgr involved in several pathways and played different roles in them. We selected most pathways fgr participated on our site, such as Chemokine signaling pathway, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with fgr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemokine signaling pathway BCAR1; CCL21B; PIK3CG; HCK; PRKACA; GNG2; NFKBIA; MAPK3; GNG12; CCL6
    Epstein-Barr virus infection POLR1C; HSPA8; IFNG; NEDD4; PIK3CB; HLA-DRB1; HLA-DRB3; NFKB2; DDX58; ENTPD1

    fgr has several biochemical functions, for example, ATP binding, Fc-gamma receptor I complex binding, immunoglobulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by fgr itself. We selected most functions fgr had, and list some proteins which have the same functions with fgr. You can find most of the proteins on our site.

    Function Related Protein
    Fc-gamma receptor I complex binding FGR; FLNA
    immunoglobulin receptor binding IGLC2; CLEC4D; Ighg; Ighg2b; FES; Ighg2a; FGR; IGKC; IgG3; IGLL1
    non-membrane spanning protein tyrosine kinase activity PTK6B; RIPK2; JAK3; ABL2; PTK2AB; SYK; ZAP70; JAK2B; FYNA; TNK2
    phosphotyrosine binding MAPK1; GRB2; LDLRAP1; CBL; ZAP70; MAPK3; CBLB; CBLC; FGR; PTPN3
    protein binding MPDZ; PSG5; PDLIM7; MLLT6; TLE4; PARVA; GMCL1; IRF2; F11R; FAM115A
    protein kinase binding RICTOR; MAP3K13; ATG13; HDAC4; SHC4; MAVS; HSP90AB1; CDK5RAP1; GSTP2; DAXX
    protein tyrosine kinase activity INSR; EPHA7; FYNA; MAP2K4; MAP2K6; PTK2; PTK2BB; TYRO3; FGR; TYK2

    fgr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with fgr here. Most of them are supplied by our site. Hope this information will be useful for your research of fgr.

    HSP90AB1; EGFR; ERBB2; MET; ALOX5; AR; KIT; WAS; EEF1A2; ABI1; abl-tide

    Abu Shehab, M; Damerill, I; et al. Liver mTOR Controls IGF-I Bioavailability by Regulation of Protein Kinase CK2 and IGFBP-1 Phosphorylation in Fetal Growth Restriction. ENDOCRINOLOGY 155:1327-1339(2014).
    Deng, L; Kitova, EN; et al. Mapping Protein-Ligand Interactions in the Gas Phase Using a Functional Group Replacement Strategy. Comparison of CID and BIRD Activation Methods. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 24:988-996(2013).

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