Recombinant Human FGR Protein, GST-tagged

• Cat.No.: FGR-4156H
• Product Overview: Human FGR full-length ORF ( NP_005239.1, 1 a.a. - 529 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 85.9 kDa
• AA Sequence: MGCVFCKKLEPVATAKEDAGLEGDF RSYGAADHYGPDPTKARPASSFAHI PNYSNFSSQAINPGFLDSGTIRGVS GIGVTLFIALYDYEARTEDDLTFTK GEKFHILNNTEGDWWEARSLSSGKT GCIPSNYVAPVDSIQAEEWYFGKIG RKDAERQLLSPGNPQGAFLIRESET TKGAYSLSIRDWDQTRGDHVKHYKI RKLDMGGYYITTRVQFNSVQELVQH YMEVNDGLCNLLIAPCTIMKPQTLG LAKDAWEISRSSITLERRLGTGCFG DVWLGTWNGSTKVAVKTLKPGTMSP KAFLEEAQVMKLLRHDKLVQLYAVV SEEPIYIVTEFMCHGSLLDFLKNPE GQDLRLPQLVDMAAQVAEGMAYMER MNYIHRDLRAANILVGERLACKIAD FGLARLIKDDEYNPCQGSKFPIKWT APEAALFGRFTIKSDVWSFGILLTE LITKGRIPYPGMNKREVLEQVEQGY HMPCPPGCPASLYEAMEQTWRLDPE ERPTFEYLQSFLEDYFTSAEPQYQP GDQT
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog [ Homo sapiens ]
• Official Symbol: FGR
• Synonyms: FGR; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; SRC2; tyrosine-protein kinase Fgr; c fgr; p55c fgr; p55-c-fgr protein; c-fgr protooncogene; proto-oncogene c-Fgr; c-src-2 proto-oncogene; proto-oncogene tyrosine-protein kinase FGR; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr; FLJ43153; MGC75096
• Gene ID: 2268
• mRNA Refseq: NM_001042729
• Protein Refseq: NP_001036194
• MIM: 164940
• UniProt ID: P09769