FHL3
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Official Full Name
four and a half LIM domains 3 -
Overview
The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
FHL3;four and a half LIM domains 3;four and a half LIM domains protein 3;SLIM2;FHL 3;Skeletal muscle LIM protein 2;FHL-3;SLIM-2;LIM-only protein FHL3;skeletal muscle LIM-protein 2
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
FHL3 involved in several pathways and played different roles in them. We selected most pathways FHL3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FHL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FHL3 has several biochemical functions, for example, actin binding,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FHL3 itself. We selected most functions FHL3 had, and list some proteins which have the same functions with FHL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | VILL,MYH1,AVIL,WAS,WASH1,MYO5B,PTK2,CAP2,WASLA,MACF1 |
| zinc ion binding | ZNF259,ZFAND5,CAR13,ISL2A,TRIM43B,RNF19B,RNF135,RNF212,RNF123,PRICKLE1 |
| protein binding | MAPK6,KRTAP8-1,CAPN2,ZBTB7A,MAP3K7IP3,HSCB,CYCS,KIAA1958,PKP1,NBN |
Interacting Protein
FHL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FHL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FHL3.
AIMP2;CNNM3;KLF3;WNK1;E2F8;MYBPHL
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References
- Xia, WR; Fu, WL; et al. Angiogenin Promotes U87MG Cell Proliferation by Activating NF-kappa B Signaling Pathway and Downregulating Its Binding Partner FHL3. PLOS ONE 10:-(2015).
- Molina-Navarro, MM; Trivino, JC; et al. Functional Networks of Nucleocytoplasmic Transport-Related Genes Differentiate Ischemic and Dilated Cardiomyopathies. A New Therapeutic Opportunity. PLOS ONE 9:-(2014).
