FOXC2

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FOXC2

Official Full Name forkhead box C2 (MFH-1, mesenchyme forkhead 1)
Background This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]
Synonyms FOXC2; forkhead box C2 (MFH-1, mesenchyme forkhead 1); LD; MFH1; MFH-1; FKHL14; forkhead box protein C2; MFH-1,mesenchyme forkhead 1; transcription factor FKH-14; mesenchyme fork head protein 1; forkhead-related protein FKHL14; forkhead, Drosophila, homolog-like 14;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FOXC2-28108TH Recombinant Human FOXC2 Wheat Germ N/A
    Human FOXC2-3485H Recombinant Human FOXC2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human FOXC2-4438H Recombinant Human FOXC2 Protein, GST-tagged Wheat Germ GST
    Human FOXC2-6160H Recombinant Human FOXC2 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human FOXC2-6160HCL Recombinant Human FOXC2 293 Cell Lysate HEK293 N/A
    Human FOXC2-6161H Recombinant Human FOXC2 protein, His-tagged E.coli His
    Mouse Foxc2-3071M Recombinant Mouse Foxc2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Chicken FOXC2-6695C Recombinant Chicken FOXC2 Mammalian Cell His

    FOXC2 involved in several pathways and played different roles in them. We selected most pathways FOXC2 participated on our site, such as Adipogenesis, Heart Development, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adipogenesis PIANP; MEF2AA; DVL1; PLIN2; NR1H3; NCOA2; MEF2B; GATA2A; KLF6; CNTFR
    Heart Development SMYD1; FOXC1; GATA6; BMP10; IRX4; NKX2; NKX2-5; HEY2; FOXH1; TBX20

    FOXC2 has several biochemical functions, for example, chromatin DNA binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXC2 itself. We selected most functions FOXC2 had, and list some proteins which have the same functions with FOXC2. You can find most of the proteins on our site.

    Function Related Protein
    chromatin DNA binding CLOCK; BCL6; VAX1; AASS; HIST1H1A; H2AFZ; HDAC3; SRF; NEUROG3; INSM1B
    protein binding UFD1L; N4BP2L2; NATD1; TAG-260; SRSF3; MPZL2B; DDX23; AMY1B; AGXT2L2; IRAK1
    sequence-specific DNA binding RARB; TBX1; NR6A1B; ETV5B; SALL1A; FOXC1; TP53; HOXD11; CREMB; FOXD4L1
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding PURA; RFX1; MITF; HNF1B; GATA6; SRF; AHR; NR5A1; MYOG; USF2
    transcription factor activity, sequence-specific DNA binding ZNF37A; ZNF192; GRHL2B; SOX3; CDX1A; CNOT8; E2F3; PBX1; IKZF4; NR1D4A
    transcription regulatory region DNA binding CTNNB1; RCOR1; BCL11B; Arid4b; PAX8; NFE2L2; ZNF613; XBP1; SIX1; HHEX
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding NEUROG3; HNF1A; TP73; HOXA7; CTCFL; POU2F3; NEUROD6; MEF2A; ETV6; NFKB2

    FOXC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXC2.

    TRIM27; PPP2R2A; TAX1BP1; RBPMS; q96iq6_human; PIN1; MYC; PPP2R1A

    Li, YJ; El Mozen, LA; et al. Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint. SCIENTIFIC REPORTS 5:-(2015).
    Bai, XM; Wang, J; et al. Prostaglandin E-2 stimulates beta 1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-kappa B pathway. SCIENTIFIC REPORTS 4:-(2014).

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