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FOXC2

  • Official Full Name

    forkhead box C2 (MFH-1, mesenchyme forkhead 1)

  • Overview

    This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]
  • Synonyms

    FOXC2; forkhead box C2 (MFH-1, mesenchyme forkhead 1); LD; MFH1; MFH-1; FKHL14; forkhead box protein C2; MFH-1,mesenchyme forkhead 1; transcription factor FKH-14; mesenchyme fork head protein 1; forkhead-related protein FKHL14; forkhead, Drosophila, homolog-like 14;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FOXC2-28108TH Recombinant Human FOXC2 Wheat Germ N/A 81 amino acids
Human FOXC2-6160H Recombinant Human FOXC2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FOXC2-6161H Recombinant Human FOXC2 protein, His-tagged E.coli His full length
Human FOXC2-6160HCL Recombinant Human FOXC2 293 Cell Lysate HEK293 N/A
Human FOXC2-3485H Recombinant Human FOXC2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FOXC2-5898HFL Recombinant Full Length Human FOXC2 protein, Flag-tagged Mamanlian cells Flag
Human FOXC2-5051HF Recombinant Full Length Human FOXC2 Protein, GST-tagged In Vitro Cell Free System GST 501 amino acids
Human FOXC2-4438H Recombinant Human FOXC2 Protein, GST-tagged Wheat Germ GST
Mouse Foxc2-3071M Recombinant Mouse Foxc2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Chicken FOXC2-6695C Recombinant Chicken FOXC2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FOXC2 Related Articles

FOXC2 involved in several pathways and played different roles in them. We selected most pathways FOXC2 participated on our site, such as Adipogenesis, Heart Development, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AdipogenesisRORAA;KLF7A;E2F4;CELF1;NR2F1A;NR2F1;CYP26A1;BMP1;MBNL1
Heart DevelopmentTBX20;TBX5;GATA6;NKX2;FOXC1;NKX2-5;SMYD1;FOXC2;FOXH1

FOXC2 has several biochemical functions, for example, chromatin DNA binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXC2 itself. We selected most functions FOXC2 had, and list some proteins which have the same functions with FOXC2. You can find most of the proteins on our site.

Function Related Protein
chromatin DNA bindingH2AFY2;RARA;H2AFY;HIST1H1A;ATOH1;APEX1;INSM1A;GRHL1;HDAC3
protein bindingBSCL2;SWSAP1;HSPA9;NMB;DNTT;TGFB1;GNG12;CBX1;C19orf44
sequence-specific DNA bindingE2F1;PTF1A;HOXB3A;FOXH1;BATF;LHX3;RARAA;WT1;GSX2
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingSOX17;CEBPA;ZFHX3;AHR;TLE4;HNF4A;ATF2;BHLHE40;POU4F1
transcription factor activity, sequence-specific DNA bindingHOXB6A;RARGB;ZFP629;TBX2A;ZFP746;ZNF461;MYT1;GAS7;ESR1
transcription regulatory region DNA bindingHIVEP2;WNT1;BRD7;MTERF3;GLI1;PAX2;ZNF821;TP73;ATF4
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingTFAP2C;MAFB;MITFA;RBPJ;PPARA;NCOA3;CREB3L1;ATOH1;TBX20

FOXC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXC2.

TRIM27; PPP2R2A; TAX1BP1; RBPMS; q96iq6_human; PIN1; MYC; PPP2R1A

Li, YJ; El Mozen, LA; et al. Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint. SCIENTIFIC REPORTS 5:-(2015).
Bai, XM; Wang, J; et al. Prostaglandin E-2 stimulates beta 1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-kappa B pathway. SCIENTIFIC REPORTS 4:-(2014).
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