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FPGS

Official Full Name

folylpolyglutamate synthase
Overview

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.
Synonyms

FPGS; folylpolyglutamate synthase; folylpolyglutamate synthase, mitochondrial; tetrahydrofolate synthase; folylpoly-gamma-glutamate synthetase; tetrahydrofolylpolyglutamate synthase;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FPGS-4483H	Recombinant Human FPGS Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	FPGS-6020M	Recombinant Mouse FPGS Protein	Mammalian Cell	His		Inquiry
Mouse	FPGS-3345M-B	Recombinant Mouse FPGS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Fpgs-739M	Recombinant Mouse Fpgs Protein, His-tagged	E.coli	His	Thr210~Cys439	Inquiry
Mouse	FPGS-3345M	Recombinant Mouse FPGS Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	FPGS-12608Z	Recombinant Zebrafish FPGS	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FPGS Related Articles

FPGS involved in several pathways and played different roles in them. We selected most pathways FPGS participated on our site, such as Folate biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FPGS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Folate biosynthesis	QDPRA;PTS;DHFRL1;MOCS1;QDPR;ALPP;DHFR;GCH1;QDPRB2
Metabolic pathways	PIGU;MT-ND1;NOS1;INPP5K;NDUFA1;MTHFS;UGT1A9;PLCB1;PDHX

FPGS has several biochemical functions, for example, ATP binding, ligase activity, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FPGS itself. We selected most functions FPGS had, and list some proteins which have the same functions with FPGS. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	SUPV3L1;STK3;CDK13;TNNI3K;PANK3;KIF20B;RET;CLPB;ACSM5
ligase activity	RFWD2;RNF6;TRAF6;MKRN3;UHRF2;RNF34;TTC3;PRPF19;MARCH9
nucleotide binding	TIAL1;RBM34;TRIOA;RAF1B;ABCG2B;PIP5K2;CSNK1G2B;CDK14;RAB14L
tetrahydrofolylpolyglutamate synthase activity

FPGS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FPGS here. Most of them are supplied by our site. Hope this information will be useful for your research of FPGS.

Li, L; Hill-Skinner, S; et al. The maize brown midrib4 (bm4) gene encodes a functional folylpolyglutamate synthase. PLANT JOURNAL 81:493-504(2015).

Nowak, D; Liem, NLM; et al. Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance. EXPERIMENTAL HEMATOLOGY 43:32-43(2015).