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FRAT2

Official Full Name

frequently rearranged in advanced T-cell lymphomas 2
Overview

The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.
Synonyms

FRAT2; frequently rearranged in advanced T-cell lymphomas 2; GSK-3-binding protein FRAT2; GSK 3 binding protein FRAT2; GSK-3 binding protein FRAT2; FRAT-2;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FRAT2-666HCL	Recombinant Human FRAT2 cell lysate		N/A		Inquiry
Human	FRAT2-5144HF	Recombinant Full Length Human FRAT2 Protein, GST-tagged	In Vitro Cell Free System	GST	233 amino acids	Inquiry
Human	FRAT2-4491H	Recombinant Human FRAT2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	FRAT2-6031M	Recombinant Mouse FRAT2 Protein	Mammalian Cell	His		Inquiry
Mouse	FRAT2-3354M-B	Recombinant Mouse FRAT2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	FRAT2-3354M	Recombinant Mouse FRAT2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
FRAT2 Related Articles

FRAT2 involved in several pathways and played different roles in them. We selected most pathways FRAT2 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FRAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Wnt signaling pathway	RAC3;WIF1;ROCK2;LRP6;DAAM1;CTNNBIP1;TBL1Y;CAMK2G1;PLCB3

FRAT2 has several biochemical functions, for example, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by FRAT2 itself. We selected most functions FRAT2 had, and list some proteins which have the same functions with FRAT2. You can find most of the proteins on our site.

Function	Related Protein
molecular_function	TSNAXIP1;GM10591;PRRG4;SPON2A;PPP4R1L;SLC41A1;SDR16C6;PALM3;TMEM108

FRAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FRAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FRAT2.

BUB1; EGFR; NRAS; KRAS; ERBB2; MCC; CTNNA1; MLH1; PTPN12; CDKN2A; MLH3; GSK3B

Walf-Vorderwulbecke, V; de Boer, J; et al. Frat2 mediates the oncogenic activation of Rac by MLL fusions. BLOOD 120:4819-4828(2012).

Lachenmayer, A; Alsinet, C; et al. Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib. CLINICAL CANCER RESEARCH 18:4997-5007(2012).