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Fzd1

Official Full Name

frizzled family receptor 1
Overview

Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif.The FZD1 transcript is expressed in various tissues.
Synonyms

FZD1; frizzled family receptor 1; frizzled (Drosophila) homolog 1 , frizzled 1, seven transmembrane spanning receptor , frizzled homolog 1 (Drosophila); frizzled-1; DKFZp564G072; frizzled; Drosophila; homolog of; 1; Wnt receptor; fz-1; fzE1; hFz1; frizz;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Gallus gallus (Chicken)
Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)
Xenopus laevis (African clawed frog)
Zebrafish

Source

E.coli
E.coli expression system
HEK293
Human Cell
Mammalian Cell
Mammalian cells

Tag

C
Fc
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FZD1-1238H	Recombinant Human FZD1 protein, His & T7-tagged	E.coli	His/T7	Gln117~Trp322 (Accession # Q9UP38)	Inquiry
Human	FZD1-3201H	Recombinant Human FZD1 Protein (Gln117-Trp322), N-His tagged	E.coli	N-His	Gln117-Trp322	Inquiry
Mouse	Fzd1-1014M	Active Recombinant Mouse Fzd1 Protein, Fc Chimera	Mammalian cells	Fc		Inquiry
Mouse	Fzd1-2292M	Recombinant Mouse Fzd1 protein, His-tagged	HEK293	His	Met1-His248	$623 / 50 µg
Mouse	Fzd1-1239M	Recombinant Mouse Fzd1 protein, His & T7-tagged	E.coli	His/T7	Gln112~Trp317 (Accession # O70421)	Inquiry
Mouse	FZD1-2633MCL	Recombinant Mouse FZD1 cell lysate	Human Cell	N/A		Inquiry
Mouse	Fzd1-5672M	Recombinant Mouse Fzd1 Protein (Val69-His248), C-Fc tagged	Mammalian cells	C-Fc	Val69-His248	Inquiry
Mouse	Fzd1-51M-B	Recombinant Mouse Fzd1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Fzd1-51M	Recombinant Mouse Fzd1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Gallus gallus (Chicken)	RFL6339GF	Recombinant Full Length Chicken Frizzled-1(Fzd1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (49-592)	Inquiry
Homo sapiens (Human)	RFL13692HF	Recombinant Full Length Human Frizzled-1(Fzd1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (70-647)	Inquiry
Mus musculus (Mouse)	RFL21067MF	Recombinant Full Length Mouse Frizzled-1(Fzd1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (69-642)	Inquiry
Xenopus laevis (African clawed frog)	RFL36410XF	Recombinant Full Length Xenopus Laevis Frizzled-1(Fzd1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (36-559)	Inquiry
Zebrafish	FZD1-7095Z	Recombinant Zebrafish FZD1	Mammalian Cell	His		Inquiry
Chicken	FZD1-2223C	Recombinant Chicken FZD1	Mammalian Cell	His		Inquiry

Fzd1 involved in several pathways and played different roles in them. We selected most pathways Fzd1 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fzd1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Wnt signaling pathway	PRKACA;WNT11R;PRICKLE2B;FZD3B;NFATC4;PPP3CC;PPARD;WNT11;FZD3
Hippo signaling pathway	SMAD2;RASSF1;ID1;WNT9B;MOB1A;SMAD4;SMAD1;CDH1;WNT9A
Signaling pathways regulating pluripotency of stem cells	FZD6;LIF;WNT7B;SMAD4;HNF1A;MAP2K1;RAF1;HESX1;ACVR1C
Melanogenesis	RAF1B;GNAO1A;WNT11;WNT4;CALML5;WNT2BA;CAMK2G1;FZD3A;WNT11R
HTLV-I infection	HLA-A;TNFRSF1A;CREM;WNT8B;EGR1;ANAPC11;HLA-DRB3;CD3E; CD3D;FZD8
Pathways in cancer	APC2;PTK2;STK36;PLCB2;GNGT2;KITLG;MAX;PGF;GNB1
Proteoglycans in cancer	ITGA2;TIMP3;FZD5;PPP1CA;CCND1;RHOA;ROCK1;PLCG1;RRAS2
Basal cell carcinoma	GLI1;FZD2;WNT5A;WNT10B;WNT7B;FZD9;DVL1;SMO;DVL3

Fzd1 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fzd1 itself. We selected most functions Fzd1 had, and list some proteins which have the same functions with Fzd1. You can find most of the proteins on our site.

Function	Related Protein
G-protein coupled receptor activity	CXCR4;LPAR3;OLFR186;VMN1R52;S1PR3;BAI1;OPRL1;PTGER4A;OR5V1
PDZ domain binding	KIDINS220B;ARHGEF16;MAP2K2;ATP2B1;CLCN3;CXADR;EXOC4;BAIAP2;FZD8
Wnt-activated receptor activity	FZD9B;FZD3;Fzd4;LRP5;FZD9;FZD8;FZD10;FZD1;FZD7B
Wnt-protein binding	SZL;SMO;WLS;FZD7B;CTHRC1;FZD6;GPR177;FZD3B;LRP5
frizzled binding	MYOC;WNT2B;WNT5A;DVL2;FZD1;WNT11;WNT1;WNT2BB;ROR2
identical protein binding	TRIM21;ALDOA;DYNLRB1;SHANK1;ESYT2;HAND2;ZNF212;GBP1;DYNLT3
protein heterodimerization activity	GTF2A1;HIST3H3;HIST1H4B;TAP1;HIST1H3C;RXRA;SMAD1;H2AFJ;PDX1
protein homodimerization activity	SRR;P2RX7;S100B;PDGFC;CALCOCO2;MCL1A;TDG;CTBP2;HMOX1
receptor binding	CADM1;LYN;ANGPTL2;FZD8;TNFSF13;MCHR1;CADM4;NCK1;CCL13
signal transducer activity	OLFR486;OLFR510;PLCD1B;TAAR10C;PTK2AB;AXIN1;MRGPRB1;GNGT2;TAS2R137
transmembrane signaling receptor activity	TRPV1;TNFRSF11A;OR4F29;BAI2;NFAM1;LAG3;GP1BB;TLR18;THBD

Fzd1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fzd1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fzd1.

Blondeau, JJC; Deng, M; et al. Identification of novel long non-coding RNAs in clear cell renal cell carcinoma. CLINICAL EPIGENETICS 7:-(2015).

Wang, YH; Motoji, T; et al. Knockdown of a Wnt Receptor FZD1 reduces MDR1/P-Glycoprotein Expression in Human Leukemia Cells through the Wnt/beta-Catenin Signaling Pathway. BLOOD 124:-(2014).

Cytokine and Growth Factor Receptors on VSMC

Wnt Receptors

Frizzled Receptors