Fzd1

  • Official Full Name

    frizzled family receptor 1

  • Overview

    Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif.The FZD1 transcript is expressed in various tissues.
  • Synonyms

    FZD1; frizzled family receptor 1; frizzled (Drosophila) homolog 1 , frizzled 1, seven transmembrane spanning receptor , frizzled homolog 1 (Drosophila); frizzled-1; DKFZp564G072; frizzled; Drosophila; homolog of; 1; Wnt receptor; fz-1; fzE1; hFz1; frizz;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Xenopus laevis (African clawed frog)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • Fc
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FZD1-1238H Recombinant Human FZD1 protein, His & T7-tagged E.coli His/T7 Gln117~Trp322 (Accession # Q9UP38)
Human FZD1-3201H Recombinant Human FZD1 Protein (Gln117-Trp322), N-His tagged E.coli N-His Gln117-Trp322
Mouse Fzd1-1014M Active Recombinant Mouse Fzd1 Protein, Fc Chimera Mammalian cells Fc
Mouse Fzd1-2292M Recombinant Mouse Fzd1 protein, His-tagged HEK293 His Met1-His248
Mouse Fzd1-1239M Recombinant Mouse Fzd1 protein, His & T7-tagged E.coli His/T7 Gln112~Trp317 (Accession # O70421)
Mouse FZD1-2633MCL Recombinant Mouse FZD1 cell lysate Human Cell N/A
Mouse Fzd1-5672M Recombinant Mouse Fzd1 Protein (Val69-His248), C-Fc tagged Mammalian cells C-Fc Val69-His248
Mouse Fzd1-51M-B Recombinant Mouse Fzd1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Fzd1-51M Recombinant Mouse Fzd1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Gallus gallus (Chicken) RFL6339GF Recombinant Full Length Chicken Frizzled-1(Fzd1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (49-592)
Homo sapiens (Human) RFL13692HF Recombinant Full Length Human Frizzled-1(Fzd1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (70-647)
Mus musculus (Mouse) RFL21067MF Recombinant Full Length Mouse Frizzled-1(Fzd1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (69-642)
Xenopus laevis (African clawed frog) RFL36410XF Recombinant Full Length Xenopus Laevis Frizzled-1(Fzd1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (36-559)
Zebrafish FZD1-7095Z Recombinant Zebrafish FZD1 Mammalian Cell His
Chicken FZD1-2223C Recombinant Chicken FZD1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • Fzd1 Related Signal Pathway

Fzd1 involved in several pathways and played different roles in them. We selected most pathways Fzd1 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fzd1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwaySOST;FZD8;MAPK8B;PPP3R1;WNT16;CAMK2D2;SFRP1;CCND1;SMAD4
Hippo signaling pathwayBMP8B;CRB2;GDF6;TGFB3;TEAD4;CTNNA2;ID1;BIRC5;WNT3A
Signaling pathways regulating pluripotency of stem cellsPCGF5;MAP2K2;INHBE;GRB2;LHX5;PIK3CA;FZD1;WNT10B;WNT8B
MelanogenesisPRKACBB;WNT2BA;PRKACBA;GNAI1;GNAO1B;MAP2K1;WNT16;CREB1A;Fzd4
HTLV-I infectionSLC25A4;HLA-DPB1;AKT2;HLA-DRA;ATF4;MYB;DVL2;HLA-C;MAPK8
Pathways in cancerGNGT1;PLCB4;PLCB2;RXRB;GLI1;HDAC1;TRAF5;PLCB3;LAMA2
Proteoglycans in cancerFGF2;ACTB;RDX;ACTG1;WNT11;VEGFA;PLCE1;RAF1;WNT7B
Basal cell carcinomaAPC;FZD2;SETD6;WNT8B;AXIN1;WNT6;FZD10;TCF7L2;WNT7B

Fzd1 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fzd1 itself. We selected most functions Fzd1 had, and list some proteins which have the same functions with Fzd1. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityTAS2R200.1;CMKLR1;CXCR4B;OPN4XA;OR4N4;VMN1R43;TAS2R114;TAS1R2.1;GPR32
PDZ domain bindingLIN7C;FZD1;Fzd4;GRIK2;SNTB1;ATP2B3B;PTENA;NSF;Apba1
Wnt-activated receptor activityFZD9;LRP6;LRP2A;FZD8B;FZD7B;FZD7A;FZD7;FZD8A;FZD10
Wnt-protein bindingFZD2;FRZB;SZL;FZD9;EVLA;PTPRO;FZD6;ROR1;CTHRC1
frizzled bindingWNT9A;WNT2B;NDP;DVL1;WNT4;FZD7;BAMBI;LRP6;FZD1
identical protein bindingACY3;COL1A1;WRNIP1;ATF3;PSME3;TLE1;RASSF1;MAPK1IP1;TFRC
protein heterodimerization activityHIST1H4K;GRIN2A;HAND1;WHRN;CAV1;BCL11A;HIST1H4A;KATNA1;GUCY1A3
protein homodimerization activityUGT1A6B;DMRTC2;OLIG2;TG;Trl;SNX6;MUC13;HINT2;XBP1
receptor bindingPLAUR;HLA-E;Icosl;AGRP2;SRPX2;CADM3;HFE;GFRA3;TNFSF10
signal transducer activityLSP1;ADCYAP1R1A;OLFR477;GNB1A;HMOX1;OLFCJ1;ECT2;DRD7;AVPR2L
transmembrane signaling receptor activityGPR126;NRXN2;SLC22A17;TNFRSF10D;KIR2DL4;CD79B;PTH1RB;FZD3B;CLDN3

Fzd1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fzd1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fzd1.

Gene Family

GPCRs

Research Area

Related articles

Blondeau, JJC; Deng, M; et al. Identification of novel long non-coding RNAs in clear cell renal cell carcinoma. CLINICAL EPIGENETICS 7:-(2015).
Wang, YH; Motoji, T; et al. Knockdown of a Wnt Receptor FZD1 reduces MDR1/P-Glycoprotein Expression in Human Leukemia Cells through the Wnt/beta-Catenin Signaling Pathway. BLOOD 124:-(2014).
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