Official Full Name | frizzled family receptor 1 |
Background | Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif.The FZD1 transcript is expressed in various tissues. |
Synonyms | FZD1; frizzled family receptor 1; frizzled (Drosophila) homolog 1 , frizzled 1, seven transmembrane spanning receptor , frizzled homolog 1 (Drosophila); frizzled-1; DKFZp564G072; frizzled; Drosophila; homolog of; 1; Wnt receptor; fz-1; fzE1; hFz1; frizz |
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Fzd1 involved in several pathways and played different roles in them. We selected most pathways Fzd1 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fzd1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Wnt signaling pathway | SENP2; FZD8B; PPP3R1; RHOAA; DKK1B; MAPK10; RAC3A; TCF7; PPP3R1B; WNT5B |
Hippo signaling pathway | BMP7; TEAD2; TEAD4; ACTB; CRB1; YWHAZ; BMPR1B; PPP2CB; BMP8B; AREG |
Signaling pathways regulating pluripotency of stem cells | FZD7; INHBB; PCGF3; ZIC3; WNT6; ESRRB; SMAD2; STAT3; GSK3B; FZD8 |
Melanogenesis | WNT10B; PRKCBB; KITLGB; PRKACB; TYRP1; PRKACBA; MAP2K2A; GSK3AA; WNT11B; TCF7L2 |
HTLV-I infection | SLC25A31; H2-AA; RAN; CDC16; VAC14; CD3G; HLA-B; WNT5A; WNT1; CDC26 |
Pathways in cancer | HRAS; HDAC1; TPR; CCNA1; PDGFB; Casp3; LAMB2; GLI1; RXRA; STAT3 |
Proteoglycans in cancer | PTPN11; WNT2; NRAS; IGF1; PRKACB; RPS6KB1; MAP2K1; SDC1; PDPK1; CAV3 |
Basal cell carcinoma | WNT4; WNT16; PTCH2; TCF7; FZD6; TRP53; WNT8B; WNT1; GSK3B; TCF7L2 |
Fzd1 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fzd1 itself. We selected most functions Fzd1 had, and list some proteins which have the same functions with Fzd1. You can find most of the proteins on our site.
Function | Related Protein |
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G-protein coupled receptor activity | AGTR1B; VMN1R46; FZD2; OLFR502; GHSR; GPR1; EDNRAB; GPR171; MRGPRA8; GRM8 |
PDZ domain binding | ARHGAP29; BAIAP2; ACCN3; NSF; GRID2; DLG1; LLGL2; PROSAPIP1; LPAR2; Fzd4 |
Wnt-activated receptor activity | FZD7; FZD8A; FZD6; FZD8B; FZD5; FZD10; FZD8; LRP5L; Fzd4; FZD3 |
Wnt-protein binding | Fzd4; SZL; LRP6; FZD8; SETD6; FZD5; PTPRO; LRP5; ROR1; LRP2A |
frizzled binding | RNF43; DVL3; WNT3A; MYOC; WNT1; WNT7A; SDCBP; WNT8B; NDP; DVL1B |
identical protein binding | SDK2; GLUL; C10orf88; GOT1; CHEK2; VWA2; ALK; CLDN20; C1QL4; INHBA |
protein heterodimerization activity | CEBPE; CHRNB2; KCNN1; HER11; IRAK3; H2AFB3; PML; UBA2; TXLNG; DRAP1 |
protein homodimerization activity | TARS; BCL2L1; UPK1A; BCL2A; DROSHA; TDG; G6PDX; GCH1; GCA; STK4 |
receptor binding | ANXA1; UFD1L; HLA-B; SEMA4D; MAG; CCL15; GNB2L1; MATK; HLA-F; PKD2 |
signal transducer activity | PTGER1A; GOLT1B; MALT1; GNG4; TAAR13C; OLFCW1; VMN1R47; GULP1; OLFR867; OLFR1013 |
transmembrane signaling receptor activity | NRXN3; IL11RA; FZD1; TNFRSF10D; FZD7A; TLR6; SPN; CD97; SIGLEC8; CD3G |
Fzd1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fzd1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fzd1.
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