Fzd1
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Official Full Name
frizzled family receptor 1 -
Overview
Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif.The FZD1 transcript is expressed in various tissues. -
Synonyms
FZD1;frizzled family receptor 1;frizzled (Drosophila) homolog 1 , frizzled 1, seven transmembrane spanning receptor , frizzled homolog 1 (Drosophila);frizzled-1;DKFZp564G072;frizzled;Drosophila;homolog of;1;Wnt receptor;fz-1;fzE1;hFz1;frizz
Recombinant Proteins
- Mouse
- Human
- Chicken
- Zebrafish
- Mus musculus
- Xenopus laevis
- HEK293
- Mammalian Cells
- E.coli
- Human Cells
- His
- Fc
- T7
- Non
- Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Fzd1-2292M |
Recombinant Mouse Fzd1 protein, His-tagged
|
HEK293 | Mouse | His | 1-248 a.a. | |
| Fzd1-1014M |
Active Recombinant Mouse Fzd1 Protein, Fc Chimera
|
Mammalian Cells | Mouse | Fc |
|
|
| FZD1-1238H | Recombinant Human FZD1 protein, His & T7-tagged | E.coli | Human | His&T7 | Gln117~Trp322 |
|
| Fzd1-1239M | Recombinant Mouse Fzd1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Gln112~Trp317 |
|
| FZD1-2223C | Recombinant Chicken FZD1 | Mammalian Cells | Chicken | His |
|
|
| FZD1-7095Z | Recombinant Zebrafish FZD1 | Mammalian Cells | Zebrafish | His |
|
|
| FZD1-2633MCL | Recombinant Mouse FZD1 cell lysate | Human Cells | Mouse | Non |
|
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| FZD1-3201H | Recombinant Human FZD1 Protein (Gln117-Trp322), N-His tagged | E.coli | Human | His | Gln117-Trp322 |
|
| Fzd1-51M | Recombinant Mouse Fzd1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
|
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| Fzd1-51M-B | Recombinant Mouse Fzd1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
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| Fzd1-5672M | Recombinant Mouse Fzd1 Protein (Val69-His248), C-Fc tagged | Mammalian Cells | Mouse | Fc | Val69-His248 |
|
| RFL13692HF | Recombinant Full Length Human Frizzled-1(Fzd1) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (70-647) |
|
| RFL21067MF | Recombinant Full Length Mouse Frizzled-1(Fzd1) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length of Mature Protein (69-642) |
|
| RFL36410XF | Recombinant Full Length Xenopus Laevis Frizzled-1(Fzd1) Protein, His-Tagged | E.coli | Xenopus laevis | His | Full L. Full Length of Mature Protein (36-559) |
|
| RFL6339GF | Recombinant Full Length Chicken Frizzled-1(Fzd1) Protein, His-Tagged | E.coli | Chicken | His | Full L. Full Length of Mature Protein (49-592) |
|
Involved Pathway
Fzd1 involved in several pathways and played different roles in them. We selected most pathways Fzd1 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fzd1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | NLK2,WNT2B,NLK1,FZD7B,NFATC4,MAPK9,TBL1X,CCND3,CSNK2A2A,NKD2 |
| Basal cell carcinoma | GLI1,SMO,WNT4,FZD3,WNT8B,WNT16,SETD6,PTCH2,WNT7A,FZD6 |
| Hippo signaling pathway | PRKCI,TGFBR1,WNT10B,TGFB2,FZD5,BMP6,BMP8B,TGFB3,CCND3,BMP2 |
| Proteoglycans in cancer | WNT2,PIK3CB,SDC2,VAV2,COL21A1,PRKACA,SDC4,MAP2K1,FZD9,ESR1 |
| HTLV-I infection | ATF4,KAT2A,TBP,SLC25A4,FOSL1,HLA-DRB1,WNT3A,TERT,PIK3R3,CANX |
| Pathways in cancer | FH,PDGFB,PIK3R5,ROCK1,ITGB1,HDAC2,Adcy4,RALB,FGF22,PLEKHG5 |
| Melanogenesis | MAP2K2,PRKCBA,WNT1,CREB3L2,PRKACAA,FZD8B,GNAIA,PRKCB,WNT8A,FZD8A |
| Signaling pathways regulating pluripotency of stem cells | WNT9B,IGF1,LEFTY2,ESRRB,ID3,WNT16,PAX6,JARID2,SKIL,PCGF5 |
Protein Function
Fzd1 has several biochemical functions, for example, G-protein coupled receptor activity,PDZ domain binding,Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fzd1 itself. We selected most functions Fzd1 had, and list some proteins which have the same functions with Fzd1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | TWIST1,DMBX1,CRYBA1,IMPA2,ODZ4,LRRFIP1,VEGFB,APOE,MECOM,GZMA |
| frizzled binding | WNT2,RNF43,WNT7A,LRP6,DVL3,WNT5B,DVL3A,WNT11R,WNT2BB,WNT3 |
| transmembrane signaling receptor activity | ERBB3,KIR2DS2,KLRD1,OR4F29,IL4R.1,ADCYAP1R1A,EDAR,CD5,TLR2-2,SEMA4D |
| identical protein binding | CPT1A,PKD2,PSME3,FTL,CALCA,ETNPPL,PFKM,PRMT8,MSANTD3,ST13 |
| Wnt-protein binding | GPR177,Fzd4,ROR2,FZD8,LRP6,WLS,SZL,PORCN,FZD7A,LRP5L |
| G-protein coupled receptor activity | OLFR473,CXCR3.2,GPR26,TAAR14L,GHRHRA,DRD1B,CHRM2A,OR10C1,GRM2,PTH1RB |
| signal transducer activity | CCR9A,TMEM9B,BMX,TAS2R136,TAAR10C,NEK6,BST2,PLK2,PLCZ1,MRGPRA5 |
| PDZ domain binding | FZD8,EXOC4,PLEKHA2,ARHGEF16,FZD7,PTEN,USHBP1,PROSAPIP1,DTNA,DLC |
| protein heterodimerization activity | CHRNA5,ZHX3,HYPM,CUL3,SNX5,BARD1,CREB3L3,RXRA,HIST3H2BB,CRLF1 |
Interacting Protein
Fzd1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fzd1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fzd1.
Fzd1 Related Signal Pathway
Resources
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References
- Blondeau, JJC; Deng, M; et al. Identification of novel long non-coding RNAs in clear cell renal cell carcinoma. CLINICAL EPIGENETICS 7:-(2015).
- Wang, YH; Motoji, T; et al. Knockdown of a Wnt Receptor FZD1 reduces MDR1/P-Glycoprotein Expression in Human Leukemia Cells through the Wnt/beta-Catenin Signaling Pathway. BLOOD 124:-(2014).
