FZD2

  • Official Full Name

    frizzled family receptor 2

  • Overview

    This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways.

  • Synonyms

    FZD2;frizzled family receptor 2;frizzled (Drosophila) homolog 2 , frizzled 2, seven transmembrane spanning receptor , frizzled homolog 2 (Drosophila);frizzled-2;Frizzled homolog 2;Frizzled2;Fz 2;Fz-2;Fz2;FZD 2;FZD2_HUMAN;FzE 2;FzE2;hFz 2;hFz2;frizzled 2, seven transmembrane spanning receptor

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Chicken
  • Zebrafish
  • Xenopus laevis
  • Mus musculus
  • E.coli
  • Mammalian Cells
  • HEK293
  • Wheat Germ
  • GST
  • His
  • Fc
  • Non
  • Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
FZD2-13065H Recombinant Human FZD2, GST-tagged E.coli Human GST 138-217a.a.
FZD2-2612H Recombinant Human FZD2 protein, His-tagged E.coli Human His 138-217 aa
Fzd2-585M Active Recombinant Mouse Frizzled Homolog 2 (Drosophila), Fc-tagged Mammalian Cells Mouse Fc 29-168 a.a.
FZD2-135H Recombinant Human FZD2 protein, Fc-tagged HEK293 Human Fc Gln24-Ser156
FZD2-2429R Recombinant Rat FZD2 Protein Mammalian Cells Rat His
FZD2-26287TH Recombinant Human FZD2 Wheat Germ Human Non 54 amino acids
FZD2-5795C Recombinant Chicken FZD2 Mammalian Cells Chicken His
FZD2-8756Z Recombinant Zebrafish FZD2 Mammalian Cells Zebrafish His
FZD2-1436H Recombinant Human FZD2 protein, Fc-tagged HEK293 Human Fc 24-190 a.a.
FZD2-1437H Recombinant Human FZD2 protein, Fc-tagged HEK293 Human Fc 24-156 a.a.
FZD2-2085R Recombinant Rat FZD2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
FZD2-2085R-B Recombinant Rat FZD2 Protein Pre-coupled Magnetic Beads HEK293 Rat
FZD2-255H Recombinant Human FZD2 Protein, Fc-tagged HEK293 Human Fc 565
FZD2-321H Recombinant Human FZD2 protein, Fc-tagged HEK293 Human Fc 167
Fzd2-380M Recombinant Mouse Fzd2 Protein, Fc-tagged HEK293 Mouse Fc Gln29-Leu168
FZD2-4591H Recombinant Human FZD2 Protein, GST-tagged Wheat Germ Human GST
Fzd2-53M Recombinant Mouse Fzd2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
Fzd2-53M-B Recombinant Mouse Fzd2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
Fzd2-6055M Recombinant Mouse Fzd2 Protein (Gln29-Leu168), C-Fc tagged Mammalian Cells Mouse Fc Gln29-Leu168
RFL12571GF Recombinant Full Length Chicken Frizzled-2(Fzd2) Protein, His-Tagged E.coli Chicken His Full L. Full Length (1-523)
RFL1807XF Recombinant Full Length Xenopus Laevis Frizzled-2(Fzd2) Protein, His-Tagged E.coli Xenopus laevis His Full L. Full Length of Mature Protein (27-551)
RFL2034MF Recombinant Full Length Mouse Frizzled-2(Fzd2) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length of Mature Protein (29-570)
RFL28554HF Recombinant Full Length Human Frizzled-2(Fzd2) Protein, His-Tagged E.coli Human His Full L. Full Length of Mature Protein (24-565)

    Involved Pathway

    FZD2 involved in several pathways and played different roles in them. We selected most pathways FZD2 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Melanogenesis FZD8,FZD6,GNA11A,GNAI3,CALML3,WNT11R,PRKCG,CAMK2A,Fzd4,GSK3B
    Wnt signaling pathway RAC1A,PRICKLE1,SIAH2L,CSNK2A2A,FZD3,PLCB4,AXIN2,MYCB,FZD8B,SENP2
    Hippo signaling pathway TGFBR1,SMAD7,WNT11,FRMD6,AMH,PPP1CA,BMPR1A,WNT9B,WNT8A,NKD1
    Signaling pathways regulating pluripotency of stem cells MYF5,STAT3,AXIN2,SMAD5,SKIL,KLF4,MAP2K2,ACVR1,ID2,WNT9A
    Proteoglycans in cancer MSN,MMP9,Fasl,ACTG1,MRAS,VAV2,SMAD2,WNT10B,ARHGEF12,HSPG2
    Basal cell carcinoma FZD1,FZD10,DVL3,HHIP,WNT6,GSK3B,WNT2B,FZD7,GLI2,FZD8
    HTLV-I infection POLE3,MAP3K3,CCNB2,TERT,PPP3CC,ANAPC1,CCND3,DLG1,WNT9B,WNT7B
    Pathways in cancer FGF7,FGF13,STAT5A,MAP2K2,CASP8,LPAR4,FGF16,STK36,CCNE2,GNAQ

    Protein Function

    FZD2 has several biochemical functions, for example, G-protein coupled receptor activity,PDZ domain binding,Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD2 itself. We selected most functions FZD2 had, and list some proteins which have the same functions with FZD2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SCRN1,NUDT12,ARMCX1,ZNF286A,UHMK1,GSDMA2,GPR143,CHD2,KIF6,SENP1
    PDZ domain binding FZD7,ATP2B4,ATP2B3B,LNX2,GRM7,SLC22A12,MAP2K2,FZD3,GRIK2,PLEKHA1
    Wnt-activated receptor activity FZD3B,FZD1,FZD8A,LRP6,FZD8B,FZD7,FZD3A,Fzd4,FZD10,FZD3
    Wnt-protein binding ROR1,FZD9,WLS,SFRP1A,GM12824,FZD7,SZL,SFRP2,SMO,GPR177
    G-protein coupled receptor activity VMN2R116,TAAR13C,V2RH14,OLFCG2,NPFFR2.1,OLFCH1,TAAR10,FZD3,OLFR958,GPR1

    Interacting Protein

    FZD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD2.

    Fyn;STAT3;C1qa

    FZD2 Related Signal Pathway

    Resources

    Gene Families

    What is GPCR
    GPCRs Class F

    Research Area

    Cytokine and Growth Factor Receptors on VSMC
    Frizzled Receptors
    Wnt Receptors
    Skin Stem Cell Markers

    References

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