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Official Full Name frizzled family receptor 3
Background This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia.
Synonyms FZD3; frizzled family receptor 3; frizzled (Drosophila) homolog 3 , frizzled 3, seven transmembrane spanning receptor , frizzled homolog 3 (Drosophila); frizzled-3; frizzled homolog 3; frizzled 3, seven transmembrane spanning receptor; Fz-3
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FZD3-12H Recombinant Human FZD3 Protein, GST-tagged Wheat Germ GST
    Human FZD3-13066H Recombinant Human FZD3, GST-tagged E.coli GST
    Human FZD3-6207H Recombinant Human FZD3 Protein, GST-tagged Wheat Germ GST
    Mouse FZD3-6117M Recombinant Mouse FZD3 Protein Mammalian Cell His
    Rhesus Macaque FZD3-1775R Recombinant Rhesus monkey FZD3 Protein, His-tagged Mammalian Cell His
    Chicken FZD3-4686C Recombinant Chicken FZD3 Mammalian Cell His
    Chicken FZD3-4687C Recombinant Chicken FZD3 Mammalian Cell His

    FZD3 involved in several pathways and played different roles in them. We selected most pathways FZD3 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway PRICKLE1A; AXIN1; WNT1; WNT2BA; CCND3; WNT10B; FZD9; NLK1; FZD2; FZD9B
    Hippo signaling pathway WNT3; CCND2; TCF7L2; GSK3B; ITGB2L; LIMD1; FZD8; APC; TGFB2; PPP1CB
    Signaling pathways regulating pluripotency of stem cells AKT2; SMAD1; WNT7B; WNT5A; SKIL; BMPR2; NANOG; NEUROG1; SMAD3; HAND1
    Melanogenesis CAMK2G; HRASB; PLCB4; CREB3L3; MAP2K2A; FZD6; GNAO1; TYR; CAMK2B1; HRAS
    Pathways in cancer MAPK1; HRAS; PTGER4; FGF21; MET; HSP90AB1; AXIN2; MAPK8; Pdgfa&Pdgfb; WNT1
    Proteoglycans in cancer FASLG; MMP9; MAPK13; PPP1R12C; ARAF; PAK1; PPP1R12A; PTPN6; FZD7; FZD8
    MicroRNAs in cancer CDC25C; TP53; MCL1; CCNE1; MMP16; MAPK1; HDAC4; IRS1; PTEN; FSCN1
    Basal cell carcinoma DVL1; FZD5; WNT5B; TCF7L2; DVL2; WNT5A; WNT3A; DVL3; TRP53; WNT3

    FZD3 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD3 itself. We selected most functions FZD3 had, and list some proteins which have the same functions with FZD3. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor activity MRGPRX1; GPR146; OLFR495; LPAR1; MC5RA; OPN1MW; ZNF514; PRLHR2A; NMUR2; TAAR12B
    PDZ domain binding PARK2; CADM1; DOCK4; GNG5; NSF; SSTR2; KIDINS220B; DLG3; ACVR2A; LLGL2
    Wnt-activated receptor activity FZD8A; FZD3; FZD7; FZD8; FZD6; LRP2A; LRP5; FZD9; FZD3B; FZD5
    Wnt-protein binding LRP2A; FZD3; SFRP1B; LRP5; GM12824; PTPRO; LRP6; EVLA; SFRP1A; FZD9B
    protein binding GRHL3; CXorf48; THAP8; MAFG; TMEM147; NR2C2AP; WIPF2; PCGF1; XIAP; MALT1

    FZD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD3.


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