FZD3

  • Official Full Name

    frizzled family receptor 3

  • Overview

    This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia.

  • Synonyms

    FZD3;frizzled family receptor 3;frizzled (Drosophila) homolog 3 , frizzled 3, seven transmembrane spanning receptor , frizzled homolog 3 (Drosophila);frizzled-3;frizzled homolog 3;frizzled 3, seven transmembrane spanning receptor;Fz-3

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Chicken
  • Mouse
  • Xenopus laevis
  • Mus musculus
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • In Vitro Cell Free System
  • HEK293
  • GST
  • His
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
FZD3-13066H Recombinant Human FZD3, GST-tagged E.coli Human GST 23-188a.a.
FZD3-12H Recombinant Human FZD3 Protein, GST-tagged Wheat Germ Human GST 55 a.a. - 157 a.a.
FZD3-1775R Recombinant Rhesus monkey FZD3 Protein, His-tagged Mammalian Cells Rhesus macaque His
FZD3-4686C Recombinant Chicken FZD3 Mammalian Cells Chicken His
FZD3-4687C Recombinant Chicken FZD3 Mammalian Cells Chicken His
FZD3-6117M Recombinant Mouse FZD3 Protein Mammalian Cells Mouse His
FZD3-6207H Recombinant Human FZD3 Protein, GST-tagged Wheat Germ Human GST 55-157 a.a.
FZD3-0294H Recombinant Human FZD3 Full Length Transmembrane protein, His-tagged E.coli Human His Full L. 23-666aa
FZD3-1082HF Recombinant Full Length Human FZD3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 55-157 amino acids
FZD3-1596R Recombinant Rhesus Macaque FZD3 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
FZD3-1596R-B Recombinant Rhesus Macaque FZD3 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
FZD3-3409M Recombinant Mouse FZD3 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
FZD3-3409M-B Recombinant Mouse FZD3 Protein Pre-coupled Magnetic Beads HEK293 Mouse
RFL16362HF Recombinant Full Length Human Frizzled-3(Fzd3) Protein, His-Tagged E.coli Human His Full L. Full Length of Mature Protein (23-666)
RFL19095XF Recombinant Full Length Xenopus Laevis Frizzled-3(Fzd3) Protein, His-Tagged E.coli Xenopus laevis His Full L. Full Length of Mature Protein (17-664)
RFL2541MF Recombinant Full Length Mouse Frizzled-3(Fzd3) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length of Mature Protein (23-666)

    Involved Pathway

    FZD3 involved in several pathways and played different roles in them. We selected most pathways FZD3 participated on our site, such as Wnt signaling pathway,Hippo signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with FZD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells WNT5A,WNT9A,TCF3,AKT1,FZD7,INHBA,PCGF1,KRAS,FZD8,WNT3
    HTLV-I infection POLD1,TERT,IL1R2,CD40,HLA-DRB5,SLC25A5,ATF4,TGFB3,ELK1,NFKBIA
    Hippo signaling pathway APC,PPP1CB,WNT4,NKD1,AXIN1,WNT6,BMPR2,SMAD3,BMP5,TEAD3
    Melanogenesis PLCB2,KITLGA,FZD10,FZD7,GNA11A,WNT9B,CALM1,GSK3AA,HRASB,MAPK1
    Wnt signaling pathway PRKCBA,NLK,PRKACBA,PPARDB,WNT11R,MYCB,FZD5,WNT9B,MAPK8,RHOAA
    Basal cell carcinoma WNT2B,WNT11,HHIP,WNT6,STK36,GLI2,Fzd4,WNT5A,SUFU,FZD1
    Proteoglycans in cancer PPP1R12C,STAT3,PRKACG,FZD1,ITGB5,FZD5,WNT8A,CTTN,ESR1,ACTB
    MicroRNAs in cancer CDC25B,WNT3A,CDC25A,NOTCH2,PDGFRB,ABCB1A,MMP16,DDIT4,HDAC4,MDM4
    Pathways in cancer RARA,MMP2,GNG2,BRCA2,TRAF6,BIRC5,CCNA1,FGFR3,CSF3R,NTRK1

    Protein Function

    FZD3 has several biochemical functions, for example, G-protein coupled receptor activity,PDZ domain binding,Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FZD3 itself. We selected most functions FZD3 had, and list some proteins which have the same functions with FZD3. You can find most of the proteins on our site.

    Function Related Protein
    Wnt-protein binding PTPRO,PORCN,SETD6,ROR1,ROR2,FZD3A,FZD2,WLS,SFRP1,FZD7B
    PDZ domain binding GIPC1,LLGL2,GNG5,ARHGEF16,KCNJ4,GRID2,CADM1,PLEKHA1,DTNA,KIDINS220
    G-protein coupled receptor activity GPR12,ADCYAP1R1A,GRIN1A,OLFR482,BAI1,OLFR78,OLFR11,VMN1R46,OR115-6,MTNR1BB
    Wnt-activated receptor activity FZD2,FZD8,FZD8A,FZD5,FZD10,FZD3B,FZD7A,FZD7,LRP5L,LRP6
    protein binding ITGAM,PLIN1,C1QTNF6,UGP2,CALCOCO2,CREB3L3,PDE9A,RUFY3,PTPRJ,RPL28

    Interacting Protein

    FZD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FZD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FZD3.

    SDCBP

    FZD3 Related Signal Pathway

    Resources

    Gene Families

    GPCRs Class F

    References

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