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Official Full Name glucose-6-phosphate dehydrogenase
Background This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms G6PD; glucose-6-phosphate dehydrogenase; G6PD1; glucose-6-phosphate 1-dehydrogenase;
    • Species :
    • Bacillus sp.
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • Bacillus sp
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human H6PD-9832H Recombinant Human H6PD Protein, His-tagged E. coli His
    Human G6PD-12H Recombinant Human G6PD Protein, His-tagged E. coli His
    Human G6PD-2397H Recombinant Human Glucose-6-phosphate Dehydrogenase, His-tagged Insect Cell His
    Human G6PD-445H Recombinant Human G6PD Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human G6PD-4615H Recombinant Human G6PD Protein, GST-tagged Wheat Germ GST
    Human G6PD-6079HCL Recombinant Human G6PD 293 Cell Lysate HEK293 N/A
    Human G6PD-6080HCL Recombinant Human G6PD 293 Cell Lysate HEK293 N/A
    Human G6PD-710H Recombinant Human G6PD protein, His-tagged E.coli His
    Human G6PD-905H Recombinant Human G6PD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Rat G6PD-2437R Recombinant Rat G6PD Protein Mammalian Cell His
    Rat G6pd-712R Recombinant Rat G6pd protein, His-tagged E.coli His
    Rhesus Macaque G6PD-1784R Recombinant Rhesus monkey G6PD Protein, His-tagged Mammalian Cell His
    Bacillus sp. G6PD-26 Native Glucose-6-phosphate dehydrogenase Bacillus sp N/A

    g6pd involved in several pathways and played different roles in them. We selected most pathways g6pd participated on our site, such as Pentose phosphate pathway, Glutathione metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with g6pd were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose phosphate pathway ALDOB; ALDOCA; deoC; ALDOCB; PRPS1A; GPI; RBKS; FBP1; G6PDX; DERA
    Glutathione metabolism RRM1; GSTT2B; MGST3; MGST1.1; GPX3; GGCTB; IDH1; LAP3; GSS; GSTM5
    Metabolic pathways HSD17B3; NDUFB1; POLA2; ST8SIA1; RDH10B; CYCSB; PTGDS; CYP2C19; PTGES; POLR2K
    Carbon metabolism TPI1; AGXT; GLDC; PDHA1; FH; FBP2; PRPS1; ACAT1; PGP; PFKM
    Central carbon metabolism in cancer SLC1A5; PDHA2; PDHB; KRAS; PGAM2; PIK3CA; ERBB2; MAP2K1; G6PD; MAPK3

    g6pd has several biochemical functions, for example, NADP binding, glucose binding, glucose-6-phosphate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by g6pd itself. We selected most functions g6pd had, and list some proteins which have the same functions with g6pd. You can find most of the proteins on our site.

    Function Related Protein
    glucose binding PYGL; UGP2; HK3; SLC2A8; HK1; SLC2A3; G6PDX; G6PD; HK2; HKDC1
    glucose-6-phosphate dehydrogenase activity G6PDX; G6PD; H6PD
    identical protein binding ZNF212; KCNH2; SYT9; BNIP2; WAS; TTC32; ASMT; SERPINA1; SH3GL3; MCM6
    protein binding GAPDH; RAB3B; NKX2-5; PARP2; ID4; TDP2; DPM2; RGS3; SYCP1; LYL1
    protein homodimerization activity GYS2; DMRT2; TOP2A; PEX11B; PGCP; CPOX; ENO3; ASNS; OLIG2; CISD2

    g6pd has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with g6pd here. Most of them are supplied by our site. Hope this information will be useful for your research of g6pd.

    SIRT2; HSPB1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; ere_dna; FN1; p14340-pro_0000037966; CTR9; Snw1

    Maiga, B; Dolo, A; et al. Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali. MALARIA JOURNAL 13:-(2014).
    Liu, XD; Zhou, B; et al. BP5 regulated B cell development promoting anti-oxidant defence. AMINO ACIDS 46:209-222(2014).

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