GATA4 Protein


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Official Full Name GATA binding protein 4
Background This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008]
Synonyms GATA4; GATA binding protein 4; ASD2; VSD1; TACHD; transcription factor GATA-4; GATA-binding factor 4;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • Myc
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GATA4-28985TH Recombinant Human GATA4 Wheat Germ N/A
    Human GATA4-3194H Recombinant Human GATA4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human GATA4-535H Recombinant Human GATA4 Protein, His-tagged E.coli His
    Human GATA4-580H Recombinant Human GATA4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human GATA4-6010HCL Recombinant Human GATA4 293 Cell Lysate HEK293 N/A
    Mouse GATA4-2441M Recombinant Mouse GATA4 Protein (1-441 aa), His-Myc-tagged E.coli His/Myc
    Rat GATA4-2482R Recombinant Rat GATA4 Protein Mammalian Cell His
    Rat Gata4-536R Recombinant Rat Gata4 Protein, His-tagged E.coli His
    Chicken GATA4-5529C Recombinant Chicken GATA4 Mammalian Cell His
    Zebrafish GATA4-8835Z Recombinant Zebrafish GATA4 Mammalian Cell His

    GATA4 involved in several pathways and played different roles in them. We selected most pathways GATA4 participated on our site, such as cGMP-PKG signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway AGTR1B; MYH7; PPP3CC; MEF2D; CREB3L2; ATP2A2; PPP3R1; PRKG2; VDAC2; GUCY1A3
    Thyroid hormone signaling pathway FOXO1; MAPK3; PRKCA; PRKCB; SIN3A; TBC1D4; MED30; TSC2; PFKP; SLC16A2

    GATA4 has several biochemical functions, for example, DNA binding, NFAT protein binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA4 itself. We selected most functions GATA4 had, and list some proteins which have the same functions with GATA4. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZFP423; TFB1M; HIST1H111L; KDM2B; SMG6; ERCC6L; PKNOX1.1; SOX1; HIST2H3C; NRL
    NFAT protein binding PPARA; SFPI1; GATA4; MAPK14; FOXP3; SPI1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding LEF1; PYDC3; ETV4; HLTF; BATF; NOBOX; SIX4; ZNF217; SMAD4; MEF2A
    RNA polymerase II regulatory region sequence-specific DNA binding ATF5A; CDX1A; MYOD1; ZFY1; NHLH2; PHF21A; ARHGAP35; FOXK1; ZNF792; PRKCBP1L
    RNA polymerase II transcription factor binding SPI1; TRP53; ANKRD1; KDM1A; CHST13; TP53; MEF2A; MIXL1; SMAD4; TBX20
    activating transcription factor binding DGKQ; HDAC7A; MEF2C; ZFP516; PPARG; MEF2A; TAF9; PRDM16; HDAC7; MEF2D
    chromatin binding TP63; NCOA1; SSRP1; PHF8; KAT2B; TOX3; PDX1; UBTF; TRIM37; CSNK2B
    co-SMAD binding SMAD1; SMAD3; GATA4; TGIF1; CITED1; USP9X; SMAD6; SMAD2; FOXH1; TRIM33
    enhancer sequence-specific DNA binding SOX11; GATA1; LMO4; LDB1; KLF7B; MYT1; TFAP2B; GATA4; TBX19; SOX9
    protein binding GBP2; C1R; CDC26; NCBP1; HDAC6; ZCCHC17; FCN3; RRAGC; UTF1; ANKRD27
    protein kinase binding PDCD10; YWHAZ; HSPB1; SPRY2; RAB11FIP2; TUBB3; RAB8A; FBXO7; PTPN2; MAPT
    sequence-specific DNA binding NKX2.4B; FLI1B; EN1; RXRA; HSFX1; ERG; DMRT2B; PRDM16; RXRGA; CREMB
    transcription coactivator activity GATA3; NFATC4; CALCOCO1; SMARCE1; MYSM1; JUNB; MYOD1; MAX; CCAR1; SOX17
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GATA5; CIR1; BHLHE40; NR5A2; HNF1B; IRF8; LEF1; MEIS1; PDX1; JUN
    transcription factor activity, RNA polymerase II transcription factor binding GTF2E1; ZNF296; THRAA; SRF; HIF1A; ATF4; GATA4; YAP1; ATF2; SMAD4
    contributes_to transcription factor activity, sequence-specific DNA binding TAF7; FOXH1; TAF10; NFE2L2A; SMAD2; NKX2; VDR; MAFGB; RXRA; SOX1A
    transcription factor binding DNMT1; YWHAZ; PYDC3; SORBS3; CEBPB; HDAC3; HES6; RNF222; ARRB1; ESRRB
    transcription regulatory region DNA binding ETV5; SOX17; FOXA3; TBL1X; RELA; OVOL2; ASH2L; MESP1; SREBF1; CDK9
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding MAFGB; IRF2; ARID3A; AIRE; ELF5; IKZF3; GRHL2; ESRRG; PPARG; EAF2
    zinc ion binding KDM5A; ZCCHC2; LMO4B; MAN2C1; MLLT6; GATA4; LHX8; TRIM35-19; NR4A2; TRIM58

    GATA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA4.


    Yamak, A; Georges, RO; et al. Novel Exons in the Tbx5 Gene Locus Generate Protein Isoforms with Distinct Expression Domains and Function. JOURNAL OF BIOLOGICAL CHEMISTRY 290:6844-6856(2015).
    Zheng, Y; Thomas, A; et al. Quantitative detection of human spermatogonia for optimization of spermatogonial stem cell culture. HUMAN REPRODUCTION 29:2497-2511(2014).

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