GATA6 Protein

GATA6

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GATA6

Official Full Name GATA binding protein 6
Background This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
Synonyms GATA6; GATA binding protein 6; transcription factor GATA-6; GATA-binding factor 6;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GATA6-28981TH Recombinant Human GATA6 Wheat Germ N/A
    Human GATA6-6009HCL Recombinant Human GATA6 293 Cell Lysate HEK293 N/A
    Mouse GATA6-6227M Recombinant Mouse GATA6 Protein Mammalian Cell His
    Rat GATA6-2483R Recombinant Rat GATA6 Protein Mammalian Cell His
    Chicken GATA6-6971C Recombinant Chicken GATA6 Mammalian Cell His
    Zebrafish GATA6-9101Z Recombinant Zebrafish GATA6 Mammalian Cell His

    GATA6 involved in several pathways and played different roles in them. We selected most pathways GATA6 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Heart Development, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Factors involved in megakaryocyte development and platelet production HBG1; HBBE2; KIFAP3; KIF15; IRF2A; KIF5A; MFN2; KDM1A; AKAP1B; KIF4A
    Heart Development HEY1; FOXH1; NKX2; NKX2-5; GATA6; FOXC2; BMP10; SMYD1; TBX5; FOXC1
    Hemostasis NADL1.1; MERTK; IRF2A; KIF26A; HBBE3; SLC3A2B; CABLES1; TREM1; DOCK8; SERPINB8
    Metabolism of proteins CTSG; ARSE; MFGE8; CTSH; SEC61B; SEC22A; DPH2; ARL2; FURINB; PIGK
    Notch-mediated HES/HEY network RCAN1; GATA1; CTBP1; GATA6; TLE1; HEY1; MYB; MYOD1; ASCL1; BGLAP
    Surfactant metabolism GATA6; DMBT1; CCDC59; SFTPBB; SFTPC; GPR116; SLC34A2A; CTSH; LMCD1; ZDHHC2

    GATA6 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA6 itself. We selected most functions GATA6 had, and list some proteins which have the same functions with GATA6. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter sequence-specific DNA binding STAT5A; SMAD1; EP300; MTF1; IRF7; SOX3; H2AFZ; NSD1; TP53; H3F3A
    RNA polymerase II regulatory region sequence-specific DNA binding ZFP551; ZBTB12.2; RXRG; ZNF548; POGZA; ETV3; ZFY1; RXRB; ZSCAN2; BCL6A
    RNA polymerase II repressing transcription factor binding TCF7L2; BBS5; GSC; TBP; RBBP8; STAT3; RBPJ; MKKS; BBS4; TTC8
    RNA polymerase II transcription factor activity, sequence-specific DNA binding SIX1A; SOX5; TFDP1A; JUNBA; SP3; FEV; PLAGL1; SOX9A; POU5F1; ZNF215
    RNA polymerase II transcription factor binding Ar; MIXL1; NFATC1; MTDH; GATA1; MTA2; GATA4; GATA2A; ZFPM1; MKX
    chromatin binding SIRT7; CREBBP; NEUROD1; ZMYND11; PARP1; CSNK2B; CREB3L1; PHF21B; KLHDC3; TRPS1
    protein binding ZMAT2; MT1G; SOX6; AKT1; NUP107; ORC4L; BAHD1; MIB1; TLX3; SIRT1
    protein kinase binding CALM2; PDGFRB; TSACC; STK11IP; SHC1; GRB7; NCS1; PPME1; FBXW5; CRY1
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding PDX1; NR5A2; USF1; PURA; ATF2; RELA; MYOG; SNAI2; NR1H4; POU3F3
    transcription factor activity, sequence-specific DNA binding PRRX2; TAF4B; RBPJ; TBX21; BATF3; PRDM1; ZFP516; ZFP14; POU3F1; ETV5A
    transcription factor binding DIP2A; PIAS1; FOXC1; NIF3L1; PITX2; FOSB; LMO4; SORBS3; KAT8; INSIG2
    transcription regulatory region DNA binding STAT3; ATMIN; AHR; TP63; ARRB1; IKZF2; GLIS2; MESP1; KLF11; ERBB4
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ALX1; DMRT1; TBX5; ATF5; GATA2A; CSRNP3; GRHL3; CEBPA; BARHL1A; OSR2
    zinc ion binding HHIP; PRICKLE2A; TRIM41; ISL2; FNTB; ZDHHC7; ZNF331; SH3RF3; UBR4; ZFPL1

    GATA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA6.

    KLF13; KPNA3; o68769_yerpe

    Soma, M; Iha, M; et al. Preferential emergence of cell types expressing markers for primitive endoderm lineages in mouse embryonic stem cells expressing exogenous EGAM1 homeoprotein. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 114:342-346(2012).
    Froese, N; Kattih, B; et al. GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor beta/Activin Receptor-like Kinase 5 Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 286:5680-5690(2011).

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