GATA6

  • Official Full Name

    GATA binding protein 6

  • Background

    This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
  • Synonyms

    GATA6; GATA binding protein 6; transcription factor GATA-6; GATA-binding factor 6;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Price
    Human GATA6-28981TH Recombinant Human GATA6 Wheat Germ N/A
    Human GATA6-6009HCL Recombinant Human GATA6 293 Cell Lysate HEK293 N/A
    Human GATA6-046H Recombinant Human GATA6 Protein, His-tagged E.coli His
    Mouse GATA6-6227M Recombinant Mouse GATA6 Protein Mammalian Cell His
    Mouse GATA6-3485M-B Recombinant Mouse GATA6 Protein Pre-coupled Magnetic Beads HEK293
    Mouse GATA6-3485M Recombinant Mouse GATA6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat GATA6-2483R Recombinant Rat GATA6 Protein Mammalian Cell His
    Rat GATA6-2139R-B Recombinant Rat GATA6 Protein Pre-coupled Magnetic Beads HEK293
    Rat GATA6-2139R Recombinant Rat GATA6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Zebrafish GATA6-9101Z Recombinant Zebrafish GATA6 Mammalian Cell His
    Chicken GATA6-6971C Recombinant Chicken GATA6 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • GATA6 Related Articles
    • GATA6 Related Research Area

    GATA6 involved in several pathways and played different roles in them. We selected most pathways GATA6 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Heart Development, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Factors involved in megakaryocyte development and platelet productionKIF4A;GATA2;ITPK1;KIF3B;HBB-Y;KIF2A;KIF4;HBD;KIF2B
    Heart DevelopmentSMYD1;FOXC2;TBX20;HEY2;HEY1;IRX4;GATA6;FOXC1;TBX5
    HemostasisCBX5;CALU;DGKG;DOCK8;KLC3;ANXA2;RHOB;CD9B;SLC7A11
    Metabolism of proteinsDPH2;MGAT4B;EIF2B1;SEC16B;TBCC;CPE;ADAMTS13;NSMCE1;LMAN2L
    Notch-mediated HES/HEY networkYY1;MYB;GATA1;HEY1;HES6;RCAN1;MYOD1;BGLAP;TLE1
    Surfactant metabolismLMCD1;SFTPC;ZDHHC2;SLC34A2A;CKAP4;CCDC59;DMBT1;GPR116;SFTPBB

    GATA6 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA6 itself. We selected most functions GATA6 had, and list some proteins which have the same functions with GATA6. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter sequence-specific DNA bindingNSD1;ZFP335;TRP53;ZNF335;MTF1;TAL1;TFAP2B;H2AFY;TFAP2A
    RNA polymerase II regulatory region sequence-specific DNA bindingZSCAN20;TAL2;HMX1;IRF2;ZFY2;BARHL2;FOXF1;POU3F4;NFKB1
    RNA polymerase II repressing transcription factor bindingHDAC2;PPARA;RBBP8;TCF7L2;MTA1;TBX5A;GSC;MTA2;HDAC1
    RNA polymerase II transcription factor activity, sequence-specific DNA bindingBETA3;MEF2D;RELB;SOX21;ZSCAN1;PLAGL2;TFDP2;FOXM1;ERG
    RNA polymerase II transcription factor bindingMTDH;GSC;TBX6;T;GATA3;PITX2;SMAD4;SPOP;ZFPM1
    chromatin bindingNFKB2;NSD1;DLX3;TFAM;JMJD5;SMARCA2;FABP1;CBX5;HOXC13
    protein bindingLCE4A;H2-AB1;TFAM;RBM39;BAG1;MPLKIP;PRPF31;SMARCC1;TEKT5
    protein kinase bindingAPC;CDC42;GRB2;ATG13;NME2;FGR;AP2A1;HDAC7A;DUSP3
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingPOU3F3;SNAI2;FOXC2;USF2;RELA;TLE4;IRF8;GATA4;MYF5
    transcription factor activity, sequence-specific DNA bindingESR2A;POU2F1;SIM1B;E2F6;HSF5;MYNN;FOXI3B;SIX4;GABPB1
    transcription factor bindingHES4;KEAP1;PRICKLE1;TCF3;SUMO1;ETS1;TLE1;CD34;GCM1
    transcription regulatory region DNA bindingZFP382;FOXA2;ZNF821;JUN;TBP;PAX2;NFKB1;ZNF831;PRDM5
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingEP300;OSR2;OVOL2;GATA2B;FOXO3;MAFGB;REST;FOXC1;MYOCD
    zinc ion bindingAPOBEC3G;TRIM62;ADH8B;TRIP6;POLR2I;RORC;NBR1;PRKCBA;ZRANB1B

    GATA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA6.

    KLF13; KPNA3; o68769_yerpe

    Soma, M; Iha, M; et al. Preferential emergence of cell types expressing markers for primitive endoderm lineages in mouse embryonic stem cells expressing exogenous EGAM1 homeoprotein. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 114:342-346(2012).
    Froese, N; Kattih, B; et al. GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor beta/Activin Receptor-like Kinase 5 Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 286:5680-5690(2011).
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