GATA6

Official Full Name

GATA binding protein 6
Background

This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
Synonyms

GATA6; GATA binding protein 6; transcription factor GATA-6; GATA-binding factor 6;

Type:
Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species :
Chicken
Human
Mouse
Rat
Zebrafish

Source :
E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag :
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	GATA6-28981TH	Recombinant Human GATA6	Wheat Germ	N/A	Inquiry
Human	GATA6-6009HCL	Recombinant Human GATA6 293 Cell Lysate	HEK293	N/A	Inquiry
Human	GATA6-046H	Recombinant Human GATA6 Protein, His-tagged	E.coli	His	Inquiry
Mouse	GATA6-6227M	Recombinant Mouse GATA6 Protein	Mammalian Cell	His	Inquiry
Mouse	GATA6-3485M-B	Recombinant Mouse GATA6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	GATA6-3485M	Recombinant Mouse GATA6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	GATA6-2483R	Recombinant Rat GATA6 Protein	Mammalian Cell	His	Inquiry
Rat	GATA6-2139R-B	Recombinant Rat GATA6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	GATA6-2139R	Recombinant Rat GATA6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	GATA6-9101Z	Recombinant Zebrafish GATA6	Mammalian Cell	His	Inquiry
Chicken	GATA6-6971C	Recombinant Chicken GATA6	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
GATA6 Related Articles
GATA6 Related Research Area

GATA6 involved in several pathways and played different roles in them. We selected most pathways GATA6 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Heart Development, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Factors involved in megakaryocyte development and platelet production	KIF4A;GATA2;ITPK1;KIF3B;HBB-Y;KIF2A;KIF4;HBD;KIF2B
Heart Development	SMYD1;FOXC2;TBX20;HEY2;HEY1;IRX4;GATA6;FOXC1;TBX5
Hemostasis	CBX5;CALU;DGKG;DOCK8;KLC3;ANXA2;RHOB;CD9B;SLC7A11
Metabolism of proteins	DPH2;MGAT4B;EIF2B1;SEC16B;TBCC;CPE;ADAMTS13;NSMCE1;LMAN2L
Notch-mediated HES/HEY network	YY1;MYB;GATA1;HEY1;HES6;RCAN1;MYOD1;BGLAP;TLE1
Surfactant metabolism	LMCD1;SFTPC;ZDHHC2;SLC34A2A;CKAP4;CCDC59;DMBT1;GPR116;SFTPBB

GATA6 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA6 itself. We selected most functions GATA6 had, and list some proteins which have the same functions with GATA6. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II core promoter sequence-specific DNA binding	NSD1;ZFP335;TRP53;ZNF335;MTF1;TAL1;TFAP2B;H2AFY;TFAP2A
RNA polymerase II regulatory region sequence-specific DNA binding	ZSCAN20;TAL2;HMX1;IRF2;ZFY2;BARHL2;FOXF1;POU3F4;NFKB1
RNA polymerase II repressing transcription factor binding	HDAC2;PPARA;RBBP8;TCF7L2;MTA1;TBX5A;GSC;MTA2;HDAC1
RNA polymerase II transcription factor activity, sequence-specific DNA binding	BETA3;MEF2D;RELB;SOX21;ZSCAN1;PLAGL2;TFDP2;FOXM1;ERG
RNA polymerase II transcription factor binding	MTDH;GSC;TBX6;T;GATA3;PITX2;SMAD4;SPOP;ZFPM1
chromatin binding	NFKB2;NSD1;DLX3;TFAM;JMJD5;SMARCA2;FABP1;CBX5;HOXC13
protein binding	LCE4A;H2-AB1;TFAM;RBM39;BAG1;MPLKIP;PRPF31;SMARCC1;TEKT5
protein kinase binding	APC;CDC42;GRB2;ATG13;NME2;FGR;AP2A1;HDAC7A;DUSP3
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	POU3F3;SNAI2;FOXC2;USF2;RELA;TLE4;IRF8;GATA4;MYF5
transcription factor activity, sequence-specific DNA binding	ESR2A;POU2F1;SIM1B;E2F6;HSF5;MYNN;FOXI3B;SIX4;GABPB1
transcription factor binding	HES4;KEAP1;PRICKLE1;TCF3;SUMO1;ETS1;TLE1;CD34;GCM1
transcription regulatory region DNA binding	ZFP382;FOXA2;ZNF821;JUN;TBP;PAX2;NFKB1;ZNF831;PRDM5
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	EP300;OSR2;OVOL2;GATA2B;FOXO3;MAFGB;REST;FOXC1;MYOCD
zinc ion binding	APOBEC3G;TRIM62;ADH8B;TRIP6;POLR2I;RORC;NBR1;PRKCBA;ZRANB1B

GATA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA6.

KLF13; KPNA3; o68769_yerpe

Soma, M; Iha, M; et al. Preferential emergence of cell types expressing markers for primitive endoderm lineages in mouse embryonic stem cells expressing exogenous EGAM1 homeoprotein. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 114:342-346(2012).

Froese, N; Kattih, B; et al. GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor beta/Activin Receptor-like Kinase 5 Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 286:5680-5690(2011).

Transcription Regulators in VSMC

Cardiac Stem Cell Markers

Epithelial Stem Cell Transcription Factors

Early Endodermal Lineage Markers

Mesenchymal Stem Cell Transcription Factors

Endodermal Lineage Markers