GATA6
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Official Full Name
GATA binding protein 6 -
Overview
This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012] -
Synonyms
GATA6;GATA binding protein 6;transcription factor GATA-6;GATA-binding factor 6
Recombinant Proteins
- Rat
- Human
- Mouse
- Chicken
- Zebrafish
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GATA6-2483R | Recombinant Rat GATA6 Protein | Mammalian Cells | Rat | His |
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| GATA6-28981TH | Recombinant Human GATA6 | Wheat Germ | Human | Non | 100 amino acids |
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| GATA6-6227M | Recombinant Mouse GATA6 Protein | Mammalian Cells | Mouse | His |
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| GATA6-6971C | Recombinant Chicken GATA6 | Mammalian Cells | Chicken | His |
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| GATA6-9101Z | Recombinant Zebrafish GATA6 | Mammalian Cells | Zebrafish | His |
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| GATA6-6009HCL | Recombinant Human GATA6 293 Cell Lysate | HEK293 | Human | Non |
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| GATA6-046H | Recombinant Human GATA6 Protein, His-tagged | E.coli | Human | His |
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| GATA6-2139R | Recombinant Rat GATA6 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| GATA6-2139R-B | Recombinant Rat GATA6 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GATA6-3485M | Recombinant Mouse GATA6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| GATA6-3485M-B | Recombinant Mouse GATA6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GATA6 involved in several pathways and played different roles in them. We selected most pathways GATA6 participated on our site, such as Factors involved in megakaryocyte development and platelet production,Heart Development,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch-mediated HES/HEY network | HEY1,CTBP1,YY1,MYB,HES6,ASCL1,GATA1,TLE1,MYOD1,RCAN1 |
| Heart Development | FOXH1,TBX20,FOXC1,HEY2,HEY1,FOXC2,SMYD1,BMP10,NKX2-5,IRX4 |
| Hemostasis | GATA1,Alb,SERPINA1L,GATA2,BSG,BA1L,BA2,CFD,KLC3,STXBP3 |
| Surfactant metabolism | CTSH,GPR116,CKAP4,SFTPBB,LMCD1,CCDC59,DMBT1,ZDHHC2,SLC34A2A,SFTPC |
| Factors involved in megakaryocyte development and platelet production | MFN2,KIF9,DOCK2,KIF3B,RACGAP1,NFE2,KIF15,GATA1A,CENPE,KDM1A |
| Metabolism of proteins | TOMM70A,TIMM9,DNAJC24,TBCD,ACE,ADAMTSL4,TIMM17B,CPA3,MUC12,SPON1A |
Protein Function
GATA6 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA6 itself. We selected most functions GATA6 had, and list some proteins which have the same functions with GATA6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | NR0B1,C1QBP,DACT2,WWP2,HDAC3,SLC26A5,TAF7,KDM1A,PELP1,DRG1 |
| zinc ion binding | ADAM28,RORC,CPXM2,CHD4A,ADAMTS5,AMZ2,ZDHHC15B,CAR3,ADAM23,MICAL1 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | RFX1,TLE4,NKX2-1,GLI1,NFIX,MYF6,RFX3,T,SOX9,NFATC1 |
| RNA polymerase II core promoter sequence-specific DNA binding | TRP53,FOS,ZFPM1,EGR1,SMAD1,STAT6,RUVBL2,SP1,TAL1,H2AFY |
| chromatin binding | CDCA5,CENPA,MEIOB,BRD3,APTX,CDC45,HMGB2,HDAC5,EYA3,RELB |
| protein binding | PIAS1,KIAA1274,YEATS4,ASNA1,DYRK1B,ANLN,STX10,NFKB2,PDLIM4,SNCAIP |
| RNA polymerase II regulatory region sequence-specific DNA binding | ZNF773,ZFAT,ZNF8,GFI1AA,IRF2,HSF2,ZNF548,ZNF549,ETV3,ZIK1 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXC1,LMO2,ELF5,SOX9B,NPAS1,TFAP2E,BETA3,FOXD4,SOX8A,FOXG1C |
| transcription factor activity, sequence-specific DNA binding | ZNF217,KLF2,MYC,FOXO1B,ATOH8,SOX4,RFX8,PROX1,SMAD3,PBX1B |
Interacting Protein
GATA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA6.
KLF13;KPNA3;o68769_yerpe
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References
- Soma, M; Iha, M; et al. Preferential emergence of cell types expressing markers for primitive endoderm lineages in mouse embryonic stem cells expressing exogenous EGAM1 homeoprotein. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 114:342-346(2012).
- Froese, N; Kattih, B; et al. GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor beta/Activin Receptor-like Kinase 5 Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 286:5680-5690(2011).
