GATA6

  • Official Full Name

    GATA binding protein 6

  • Overview

    This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]

  • Synonyms

    GATA6;GATA binding protein 6;transcription factor GATA-6;GATA-binding factor 6

Recombinant Proteins

  • Rat
  • Human
  • Mouse
  • Chicken
  • Zebrafish
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • E.coli
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
GATA6-2483R Recombinant Rat GATA6 Protein Mammalian Cells Rat His
GATA6-28981TH Recombinant Human GATA6 Wheat Germ Human Non 100 amino acids
GATA6-6227M Recombinant Mouse GATA6 Protein Mammalian Cells Mouse His
GATA6-6971C Recombinant Chicken GATA6 Mammalian Cells Chicken His
GATA6-9101Z Recombinant Zebrafish GATA6 Mammalian Cells Zebrafish His
GATA6-6009HCL Recombinant Human GATA6 293 Cell Lysate HEK293 Human Non
GATA6-046H Recombinant Human GATA6 Protein, His-tagged E.coli Human His
GATA6-2139R Recombinant Rat GATA6 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
GATA6-2139R-B Recombinant Rat GATA6 Protein Pre-coupled Magnetic Beads HEK293 Rat
GATA6-3485M Recombinant Mouse GATA6 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
GATA6-3485M-B Recombinant Mouse GATA6 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    GATA6 involved in several pathways and played different roles in them. We selected most pathways GATA6 participated on our site, such as Factors involved in megakaryocyte development and platelet production,Heart Development,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Heart Development TBX20,TBX5,IRX4,FOXC2,NKX2-5,BMP10,NKX2,FOXH1,SMYD1,HEY1
    Hemostasis F3A,NFE2,KIF4A,KIF2A,S100A10B,TRPC7,TRPC3,KIF4,SLC8A2A,KIFAP3
    Factors involved in megakaryocyte development and platelet production KIF4,HBG1,BA1L,CABLES2,KIFC1,KIF5B,AKAP1,DOCK10,KIF11,IRF2A
    Notch-mediated HES/HEY network HEY1,MYB,MYOD1,ASCL1,BGLAP,HES6,GATA1,CTBP1,RCAN1,YY1
    Surfactant metabolism GPR116,SFTPC,SFTPBB,LMCD1,SLC34A2A,CCDC59,CKAP4,CTSH,ZDHHC2,DMBT1
    Metabolism of proteins SLC30A5,KLHDC3,ADD1,B3GNT2A,WDR85,NSMCE2,PHC1,TBCA,SEC16B,MLEC

    Protein Function

    GATA6 has several biochemical functions, for example, RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II repressing transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA6 itself. We selected most functions GATA6 had, and list some proteins which have the same functions with GATA6. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PRX,TCF7L2,TDRD7,GTF3C5,CLEC18A,RAB8B,PPP2R4,GAS7,RNF113A,LGALS1
    transcription regulatory region DNA binding ZFP821,KLF1,MESP1,TCF7L2,BCL11B,SMARCA2,CTCFL,GLIS2,GATA4,XRCC5
    transcription factor activity, sequence-specific DNA binding SNAPC4,NEUROD1,MNX2A,SRF,XBP1,SPI1A,MEOX1,ZFP518A,ZNF436,ATF6B
    transcription factor binding NBN,MDFI,RBFOX2,NAB1,BCL3,HES1,RNF19A,REST,RB1,PPP1R13BA
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding HIF1A,PKNOX1,CREB1,SOX9,ATF2,SFPI1,IRF8,JUN,NKX2-1,GATA5
    zinc ion binding RARAA,KDM7AB,RASGRP1,CREBBP,ADH1A,PRICKLE1B,PDLIM4,MORC2,ZDHHC6,TADA2B
    RNA polymerase II repressing transcription factor binding TCF7L2,TBX5A,HDAC2,PROL1,RBPJ,SIN3A,MKKS,DMAP1,BBS5,PPARA
    chromatin binding GPR30,SATB1,GM606,MBD5,RELA,STAG2,YAP1,BRD4,PBRM1L,CAPNS2
    RNA polymerase II core promoter sequence-specific DNA binding NLRC5,NFIL3,RREB1,SP3,MAZ,FOS,SMAD1,PAX6,H2AFY,HNF4A

    Interacting Protein

    GATA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA6.

    KLF13;KPNA3;o68769_yerpe

    Resources

    Research Area

    Transcription Regulators in VSMC
    Cardiac Stem Cell Markers
    Early Endodermal Lineage Markers
    Epithelial Stem Cell Transcription Factors
    Mesenchymal Stem Cell Transcription Factors
    Endodermal Lineage Markers

    References

    • Soma, M; Iha, M; et al. Preferential emergence of cell types expressing markers for primitive endoderm lineages in mouse embryonic stem cells expressing exogenous EGAM1 homeoprotein. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 114:342-346(2012).
    • Froese, N; Kattih, B; et al. GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor beta/Activin Receptor-like Kinase 5 Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 286:5680-5690(2011).

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