Description : |
GATA proteins comprise a group of transcription factors that are related by the presence of conserved zinc finger DNA-binding domains, which bind directly to the nucleotide sequence core element GATA. There are six vertebrate GATA proteins, designated GATA-1 to GATA-6. GATA-6 plays a critical role in endoderm development. It is essential for development of the heart, gut, and other organs. Knock out of GATA-6 is embryonic lethal due to defects in formation of the heart tube and a failure to develop extraembryonic endoderm. Loss of expression, or loss of nuclear localization of GATA-6 is apparent in a large number of ovarian tumors. |
Source : |
E. coli |
Species : |
Human |
Tag : |
His |
Molecular Mass : |
~66 kDa |
AA Sequence : |
HMALTDGGWCLPKRFGAAGADASDS RAFPAREPSTPPSPISSSSSSCSRG GERGPGGASNCGTPQLDTEAAAGPP ARSLLLSSYASHPFGAPHGPSAPGV AGPGGNLSSWEDLLLFTDLDQAATA SKLLWSSRGAKLSPFAPEQPEEMYQ TLAALSSQGPAAYDGAPGGFVHSAA AAAAAAAAASSPVYVPTTRVGSMLP GLPYHLQGSGSGPANHAGGAGAHPG WPQASADSPPYGSGGGAAGGGAAGP GGAGSAAAHVSARFPYSPSPPMANG AAREPGGYAAAGSGGAGGVSGGGSS LAAMGGREPQYSSLSAARPLNGTYH HHHHHHHHHPSPYSPYVGAPLTPAW PAGPFETPVLHSLQSRAGAPLPVPR GPSADLLEDLSESRECVNCGSIQTP LWRRDGTGHYLCNACGLYSKMNGLS RPLIKPQKRVPSSRRLGLSCANCHT TTTTLWRRNAEGEPVCNACGLYMKL HGVPRPLAMKKEGIQTRKRKPKNIN KSKTCSGNSNNSIPMTPTSTSSNSD DCSKNTSPTTQPTASGAGAPVMTGA GESTNPENSELKYSGQDGLYIGVSL ASPAEVTSSVRPDSWCALALALE |
Purity : |
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : |
For research use only, not for use in diagnostic procedure. |
Storage : |
Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Storage Buffer : |
0.5M Urea, pH7.4 |