Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

GCDH

  • Official Full Name

    glutaryl-CoA dehydrogenase

  • Overview

    The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    GCDH; glutaryl-CoA dehydrogenase; glutaryl Coenzyme A dehydrogenase; glutaryl-CoA dehydrogenase, mitochondrial; ACAD5; mitochondrial; EC 1.3.99.7; GCD; GCDH_HUMAN; Glutaryl CoA dehydrogenase, mitochondrial; MS781; glutaryl-Coenzyme A dehydrogenase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Baculovirus-Insect Cells
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cells
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GCDH-2728H Recombinant Human Glutaryl-CoA Dehydrogenase, His-tagged E.coli His
Human GCDH-27464TH Recombinant Human GCDH, His-tagged E.coli His 394 amino acids
Human GCDH-5992HCL Recombinant Human GCDH 293 Cell Lysate HEK293 N/A
Human GCDH-4790H Recombinant Human GCDH Protein, GST-tagged Wheat Germ GST
Human GCDH-275H Recombinant Human GCDH protein (Met1-Lys438), His-tagged Baculovirus-Insect Cells His
Human GCDH-2187H Recombinant Human GCDH protein, His-tagged Insect Cells His Met1-Lys438
Human GCDH-6691H Recombinant Human GCDH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GCDH-5167HF Recombinant Full Length Human GCDH Protein, GST-tagged In Vitro Cell Free System GST 438 amino acids
Human GCDH-2333H Recombinant Human GCDH Protein (Arg45-Lys438), N-His tagged E.coli N-His Arg45-Lys438
Human GCDH-2334H Recombinant Human GCDH Protein (Thr31-Pro204) E.coli Tag Free Thr31-Pro204
Human GCDH-2335H Recombinant Human GCDH Protein (Glu270-Lys438), N-His tagged E.coli N-His Glu270-Lys438
Mouse GCDH-6259M Recombinant Mouse GCDH Protein Mammalian Cell His
Mouse Gcdh-8166M Recombinant Mouse Gcdh protein, His & T7-tagged E.coli His/T7 Glu270~Lys438 (Accession # Q60759)
Mouse GCDH-3503M Recombinant Mouse GCDH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Gcdh-3171M Recombinant Mouse Gcdh Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse GCDH-3503M-B Recombinant Mouse GCDH Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GCDH-539C Recombinant Cynomolgus GCDH Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey GCDH-284C Recombinant Cynomolgus Monkey GCDH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey GCDH-284C-B Recombinant Cynomolgus Monkey GCDH Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GCDH Related Articles

GCDH involved in several pathways and played different roles in them. We selected most pathways GCDH participated on our site, such as Fatty acid degradation, Lysine degradation, Tryptophan metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid degradationACSL3A;ADH1C;ADH2-1;GCDHA;ACSL4A;HADHAB;ACAA1A;ADH1B;ACADM
Lysine degradationASH1L;EHMT1B;ALDH1B1;WBP7;SUV39H1B;DOT1L;KMT2E;HYKK;ALDH9A1B
Tryptophan metabolismAOX1;ANI_1_2390104;ACAT2;OGDHA;AOX3L1;AADAT;CCBL1;ASMT;AOX3
Metabolic pathwaysUGP2;PCXB;MCEE;LIPT1;MINPP1A;ALPI.1;GUK1B;LDHBB;UQCRC2B

GCDH has several biochemical functions, for example, electron carrier activity, fatty-acyl-CoA binding, flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCDH itself. We selected most functions GCDH had, and list some proteins which have the same functions with GCDH. You can find most of the proteins on our site.

Function Related Protein
electron carrier activityNDUFS1;ACOX2;ALDH4A1;CYP19A1;ACAD9;GCDH;DERL3;COX7A3;GPX2
fatty-acyl-CoA bindingECI2;ACOX1;ACADSB;ACAD11;IVD;ACBD5A;ACBD7;ACOXL;ACAD8
flavin adenine dinucleotide bindingACADVL;KDM1A;ACADM;FMO1;KDM1B;GFER;DMGDH;IVD;ACOX1
glutaryl-CoA dehydrogenase activity
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptorACAD11;ACAD8;ACOX1;IVD;ACADM;ETFA;GCDHB;ACADVL;ACOXL

GCDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCDH here. Most of them are supplied by our site. Hope this information will be useful for your research of GCDH.

NOS3; PSEN1; GRB2; A2M; APOE; CDC37; EXOC6; ECSIT; RNF32; 2_aha_camp; 8-aha-camp; 8-aha-omethyladenosine; MYC; CLPP; P; Ccdc12

Gerstner, B; Gratopp, A; et al. Glutaric acid and its metabolites cause apoptosis in immature oligodendrocytes: A novel mechanism of white matter degeneration in glutaryl-CoA dehydrogenase deficiency. PEDIATRIC RESEARCH 57:771-776(2005).
Kolker, S; Ahlemeyer, B; et al. Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: A new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency. PEDIATRIC RESEARCH 47:495-503(2000).
Kolker, S; Ahlemeyer, B; et al. Cerebral organic acid disorders induce neuronal damage via excitotoxic organic acids in vitro. AMINO ACIDS 18:31-40(2000).
KLEES, AG; LINDER, D; et al. 2-HYDROXYGLUTARYL-COA DEHYDRATASE FROM FUSOBACTERIUM-NUCLEATUM (SUBSP NUCLEATUM) - AN IRON-SULFUR FLAVOPROTEIN. ARCHIVES OF MICROBIOLOGY 158:294-301(1992).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All GCDH Products

Required fields are marked with *

My Review for All GCDH Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends