GCDH
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Official Full Name
glutaryl-CoA dehydrogenase
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Overview
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
GCDH; glutaryl-CoA dehydrogenase; glutaryl Coenzyme A dehydrogenase; glutaryl-CoA dehydrogenase, mitochondrial; ACAD5; mitochondrial; EC 1.3.99.7; GCD; GCDH_HUMAN; Glutaryl CoA dehydrogenase, mitochondrial; MS781; glutaryl-Coenzyme A dehydrogenase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Baculovirus-Insect Cells
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cells
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- GCDH Related Articles
GCDH involved in several pathways and played different roles in them. We selected most pathways GCDH participated on our site, such as Fatty acid degradation, Lysine degradation, Tryptophan metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fatty acid degradation | ACSL3A;ADH1C;ADH2-1;GCDHA;ACSL4A;HADHAB;ACAA1A;ADH1B;ACADM |
Lysine degradation | ASH1L;EHMT1B;ALDH1B1;WBP7;SUV39H1B;DOT1L;KMT2E;HYKK;ALDH9A1B |
Tryptophan metabolism | AOX1;ANI_1_2390104;ACAT2;OGDHA;AOX3L1;AADAT;CCBL1;ASMT;AOX3 |
Metabolic pathways | UGP2;PCXB;MCEE;LIPT1;MINPP1A;ALPI.1;GUK1B;LDHBB;UQCRC2B |
GCDH has several biochemical functions, for example, electron carrier activity, fatty-acyl-CoA binding, flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCDH itself. We selected most functions GCDH had, and list some proteins which have the same functions with GCDH. You can find most of the proteins on our site.
Function | Related Protein |
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electron carrier activity | NDUFS1;ACOX2;ALDH4A1;CYP19A1;ACAD9;GCDH;DERL3;COX7A3;GPX2 |
fatty-acyl-CoA binding | ECI2;ACOX1;ACADSB;ACAD11;IVD;ACBD5A;ACBD7;ACOXL;ACAD8 |
flavin adenine dinucleotide binding | ACADVL;KDM1A;ACADM;FMO1;KDM1B;GFER;DMGDH;IVD;ACOX1 |
glutaryl-CoA dehydrogenase activity | |
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | ACAD11;ACAD8;ACOX1;IVD;ACADM;ETFA;GCDHB;ACADVL;ACOXL |
GCDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCDH here. Most of them are supplied by our site. Hope this information will be useful for your research of GCDH.
NOS3; PSEN1; GRB2; A2M; APOE; CDC37; EXOC6; ECSIT; RNF32; 2_aha_camp; 8-aha-camp; 8-aha-omethyladenosine; MYC; CLPP; P; Ccdc12
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