| Description : |
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
48.1 kDa |
| AA Sequence : |
MALRGVSVRLLSRGPGLHVLRTWVS SAAQTEKGGRTQSQLAKSSRPEFDW QDPLVLEEQLTTDEILIRDTFRTYC QERLMPRILLANRNEVFHREIISEM GELGVLGPTIKGYGCAGVSSVAYGL LARELERVDSGYRSAMSVQSSLVMH PIYAYGSEEQRQKYLPQLAKGELLG CFGLTEPNSGSDPSSMETRAHYNSS NKSYTLNGTKTWITNSPMADLFVVW ARCEDGCIRGFLLEKGMRGLSAPRI QGKFSLRASATGMIIMDGVEVPEEN VLPGASSLGGPFGCLNNARYGIAWG VLGASEFCLHTARQYALDRMQFGVP LARNQLIQKKLADMLTEITLGLHAC LQLGRLKDQDKAAPEMVSLLKRNNC GKALDIARQARDMLGGNGISDEYHV IRHAMNLEAVNTYEGTHDIHALILG RAITGIQAFTASKTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
