gdi1 Protein, GDP dissociation inhibitor 1

gdi1

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gdi1

Official Full Name GDP dissociation inhibitor 1
Background GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family,;small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between;cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound;rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked;nonspecific mental retardation.
Synonyms GDI1; GDP dissociation inhibitor 1; rab GDP dissociation inhibitor alpha; FLJ41411; GDI-1; GDIA_HUMAN; Guanosine diphosphate dissociation inhibitor 1; Mental retardation X-linked 41; Mental retardation X-linked 48; MRX41; MRX48; Oligophrenin 2; Oligophrenin-2; OPHN2; Protein XAP 4; Protein XAP-4; Protein XAP4; Rab GDI alpha; RABGD1A; RABGDIA; XAP 4; SMG p25A GDI
    • Species :
    • Bovine
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GDI1-196H Recombinant Human GDI1, His-tagged E.coli His
    Human GDI1-4831H Recombinant Human GDI1 Protein, GST-tagged Wheat Germ GST
    Human GDI1-5965HCL Recombinant Human GDI1 293 Cell Lysate HEK293 N/A
    Human GDI1-640H Recombinant Human GDI1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse GDI1-6291M Recombinant Mouse GDI1 Protein Mammalian Cell His
    Rat GDI1-2504R Recombinant Rat GDI1 Protein Mammalian Cell His
    Cynomolgus Monkey GDI1-542C Recombinant Cynomolgus GDI1 Protein, His-tagged Mammalian Cell His
    Bovine GDI1-1120B Recombinant Bovine GDP Dissociation Inhibitor 1 Sf9 Insect Cell N/A
    Bovine GDI1-715B Recombinant Bovine GDI1 Protein Insect Cell N/A
    Zebrafish GDI1-2787Z Recombinant Zebrafish GDI1 Mammalian Cell His

    gdi1 involved in several pathways and played different roles in them. We selected most pathways gdi1 participated on our site, such as Integrated Breast Cancer Pathway, Rho GTPase cycle, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with gdi1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Integrated Breast Cancer Pathway GRN; APOBEC3G; USP16; DAG1; SMARCA4; CCNB1IP1; DHTKD1; RPP38; NAB1; AHR
    Rho GTPase cycle ARAP2; ARHGAP11A; FGD4A; RALBP1; ARHGEF17; RHOT2; ARHGAP32; ARHGAP17A; RHOT1B; ARHGAP1
    Signal Transduction CCK; FSTL1B; MDKA; TLE3B; DHRS4; GMIP; USP9X; FSTB; LEO1; ADM
    Signaling by Rho GTPases ARHGAP36; RHOU; RHPN1; ARHGAP24; ARHGAP19; TAGAPA; ARHGAP9; ARHGAP25; ARHGEF16; RHOV
    Signaling mediated by p38-alpha and p38-beta USF1; KRT8; GDI1; HBP1

    gdi1 has several biochemical functions, for example, GDP-dissociation inhibitor activity, GTPase activator activity, Rab GDP-dissociation inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by gdi1 itself. We selected most functions gdi1 had, and list some proteins which have the same functions with gdi1. You can find most of the proteins on our site.

    Function Related Protein
    GDP-dissociation inhibitor activity SH3BP4A; GPSM1; GDI1; RGS14; GPSM1B; RANBP1; SH3BP4; GPSM2L; ITGB1BP1
    GTPase activator activity ARHGEF6; AGAP5; NIPAL1; ASAP1A; ARAP3; DOCK4; ARRB1; STARD13; SRGAP2; DAB2IPB
    Rab GDP-dissociation inhibitor activity GDI2; GDI1
    Rab GTPase binding EVI5L; CFAP45; RABGGTA; SYTL2; UNC13D; USP6NL; RILP; NDRG1; MLPH; AP3M1
    oxidoreductase activity CYP2AA8; TXNRD3; DHRS13B; BCO2L; DHRS13L1; Scd2; CYBASC3; CYP3A4; YWHAE2; CYP1A
    protein binding SLC4A1; PPP2R4; ELAVL1; DGKQ; BEND7; CDKN2A; TAP1; ZNF350; VAMP1; UTP3

    gdi1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gdi1 here. Most of them are supplied by our site. Hope this information will be useful for your research of gdi1.

    RAB4A; Rab10; RAB1A; LNX1; SPOP; HLA-B; YWHAZ; FBXO11; RAB24; FTSJ1; TK1; GNL1; dppA

    Gallart-Palau, X; Serra, A; et al. Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia. NEUROCHEMISTRY INTERNATIONAL 80:87-98(2015).
    D'Adamo, P; Masetti, M; et al. RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 46:302-314(2014).

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