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GDI1

  • Official Full Name

    GDP dissociation inhibitor 1

  • Overview

    GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family,;small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between;cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound;rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked;nonspecific mental retardation.
  • Synonyms

    GDI1; GDP dissociation inhibitor 1; rab GDP dissociation inhibitor alpha; FLJ41411; GDI-1; GDIA_HUMAN; Guanosine diphosphate dissociation inhibitor 1; Mental retardation X-linked 41; Mental retardation X-linked 48; MRX41; MRX48; Oligophrenin 2; Oligophrenin-2; OPHN2; Protein XAP 4; Protein XAP-4; Protein XAP4; Rab GDI alpha; RABGD1A; RABGDIA; XAP 4; SMG p25A GDI;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GDI1-196H Recombinant Human GDI1, His-tagged E.coli His 1-447aa
Human GDI1-640H Recombinant Human GDI1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GDI1-5965HCL Recombinant Human GDI1 293 Cell Lysate HEK293 N/A
Human GDI1-2448H Recombinant Human GDI1 protein, His-tagged E.coli His 1-209 aa
Human GDI1-5244HF Recombinant Full Length Human GDI1 Protein, GST-tagged In Vitro Cell Free System GST 447 amino acids
Human GDI1-4831H Recombinant Human GDI1 Protein, GST-tagged Wheat Germ GST
Human GDI1-1212HFL Recombinant Full Length Human GDI1 Protein, C-Flag-tagged Mammalian cells Flag
Human GDI1-2977H Recombinant Human GDI1 Protein (Met1-Val274), N-His tagged E.coli N-His Met1-Val274
Human GDI1-975H-B Recombinant Human GDI1 Protein Pre-coupled Magnetic Beads HEK293
Human GDI1-975H Recombinant Human GDI1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GDI1-6291M Recombinant Mouse GDI1 Protein Mammalian Cell His
Mouse GDI1-3524M Recombinant Mouse GDI1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Gdi1-3182M Recombinant Mouse Gdi1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse GDI1-3524M-B Recombinant Mouse GDI1 Protein Pre-coupled Magnetic Beads HEK293
Rat GDI1-2504R Recombinant Rat GDI1 Protein Mammalian Cell His
Rat GDI1-2160R Recombinant Rat GDI1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GDI1-2160R-B Recombinant Rat GDI1 Protein Pre-coupled Magnetic Beads HEK293
Bovine GDI1-1120B Recombinant Bovine GDP Dissociation Inhibitor 1 Sf9 Insect Cell N/A
Bovine GDI1-715B Recombinant Bovine GDI1 Protein Insect Cell N/A
Cynomolgus Monkey GDI1-542C Recombinant Cynomolgus GDI1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey GDI1-287C Recombinant Cynomolgus Monkey GDI1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey GDI1-287C-B Recombinant Cynomolgus Monkey GDI1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish GDI1-2787Z Recombinant Zebrafish GDI1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GDI1 Related Articles

GDI1 involved in several pathways and played different roles in them. We selected most pathways GDI1 participated on our site, such as Integrated Breast Cancer Pathway, Rho GTPase cycle, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Integrated Breast Cancer PathwayAPOBEC3G;USP16;ERAL1;GDI1;AHR;RPP38;CCNB1IP1;LGALS13;JAKMIP1
Rho GTPase cycleTAGAPA;ARHGAP10;RHOV;ARHGAP11A;ARHGAP31;DLC1;TAGAPB;RHOJ;CHN1
Signal TransductionARHGEF16;HEBP1;SOX4A;ABHD12;NPHP4;GPRC6A;BCO2;GPR177;CSN2
Signaling by Rho GTPasesFGD2;ARHGAP12;RTKN;KIF14;ARHGAP1;ARHGAP29;FGD4;RHOUA;ARHGAP19
Signaling mediated by p38-alpha and p38-betaUSF1;GDI1;HBP1;KRT8

GDI1 has several biochemical functions, for example, GDP-dissociation inhibitor activity, GTPase activator activity, Rab GDP-dissociation inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDI1 itself. We selected most functions GDI1 had, and list some proteins which have the same functions with GDI1. You can find most of the proteins on our site.

Function Related Protein
GDP-dissociation inhibitor activityITGB1BP1;SH3BP4A;GPSM1;GPSM1B;GPSM2L;GDI1;RANBP1;SH3BP4;RGS14
GTPase activator activityRIN1;ACAP3;TBC1D2;TBCD;ARHGAP20;VPS9D1;DAB2IPB;RASGRP3;STARD8
Rab GDP-dissociation inhibitor activityGDI2;GDI1
Rab GTPase bindingCFAP45;RABGAP1L;ODF2;ANKRD27;GAS8;EVI5;RAB11FIP5;RIMS1;GOLGA5
oxidoreductase activityAIFM4;IMPDH1B;DHRS11A;SUMF1;CBR1L;DHRS7;PDHA1A;CYP2F2;MPX
protein bindingFGFBP1;TCF3;ATP7A;ARHGAP33;CYP1A1;ACP1;BMPR1B;ATPAF2;RCN1

GDI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDI1.

RAB4A; Rab10; RAB1A; LNX1; SPOP; HLA-B; YWHAZ; FBXO11; RAB24; FTSJ1; TK1; GNL1; dppA

Gallart-Palau, X; Serra, A; et al. Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia. NEUROCHEMISTRY INTERNATIONAL 80:87-98(2015).
D'Adamo, P; Masetti, M; et al. RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 46:302-314(2014).
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