Gnas
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Official Full Name
GNAS complex locus -
Overview
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and;biallelically expressed transcripts that are derived from four alternative promoters and 5 exons. Some transcripts;contain a differentially methylated region (DMR) at their 5 exons, and this DMR is commonly found in imprinted genes;and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the;opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally;expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a;second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream;exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of;the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase;and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this;gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright;hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia,;polyostotic fibrous dysplasia of bone, and some pituitary tumors. -
Synonyms
GNAS;GNAS complex locus;Adenylate cyclase stimulating G alpha protein;Guanine nucleotide binding protein G(s) alpha subunit;neuroendocrine secretory protein 55;adenylate cyclase-stimulating G alpha protein;guanine nucleotide-binding protein G(s) subunit alpha isoforms;guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1;GNAS1
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- DDK
- Myc
- Flag
- Avi
- Fc
- SUMO
Involved Pathway
Gnas involved in several pathways and played different roles in them. We selected most pathways Gnas participated on our site, such as Rap signaling pathway,Calcium signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gnas were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | GNA11,FGF10,FGF1,COL4A1,PIK3R2,GNGT1,GLI2,STAT3,HSP90AB1,FGFR3 |
| Insulin secretion | PRKCB,ATP1A4,CREB3L3,GNA11,PLCB1,KCNMB1,ATP1A1,KCNN3,CAMK2B,INS |
| Dilated cardiomyopathy | LAMA2,EMD,TPM1,TGFB2,TPM3,CACNB2,MYH7,MYBPC3,ITGA7,PLN |
| Thyroid hormone synthesis | PRKACB,CREB3L2,GPX8,GPX5,DUOXA2,GPX6,SLC5A5,PLCB4,PRKCG,PLCB2 |
| Amoebiasis | GNA11,ITGB2,ACTN1,TNF,SERPINB6,COL24A1,ITGAM,COL5A2,ITGB2L,ACTN2 |
| Circadian entrainment | GRIA4,FOS,CACNA1H,NOS1,GNAI2,CACNA1G,PLCB1,GUCY1B3,RPS6KA5,KCNJ9 |
| Gastric acid secretion | KCNQ1,KCNK2,CAMK2A,CA2,KCNJ1,ATP1B2,CAMK2D,ATP1B4,PRKACG,CCKBR |
| Salivary secretion | PRKACG,CST5,GNAQ,ATP2B4,DMBT1,ATP1B3,HTN1,MUC7,Slc4a2,BST1 |
| Aldosterone synthesis and secretion | DDX1,SLC14A2,PRKCG,ADCY1,CALML5,PRKCB,PRKCE,PRKACB,CREB3L2,STAR |
Protein Function
Gnas has several biochemical functions, for example, D1 dopamine receptor binding,G-protein beta/gamma-subunit complex binding,GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gnas itself. We selected most functions Gnas had, and list some proteins which have the same functions with Gnas. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | PPP1R27B,CCDC81,NRM,SIRP-BETA,TMEM238,DCHS1,CMIP,CTXN2,EPHX3,STOX2 |
| protein binding | CP110,MBD4,RAB43,KHK,FSTL5,ACCS,SCAMP1,CD200R2,GSTA2,RCOR3 |
| adenylate cyclase activity | ADCY7,ADCY6,ADCY3,ADCY1B,ADCY8,ADCY1A,ADCY9,Adcy4,ADCY1,ADCY2B |
| insulin-like growth factor receptor binding | Ren1,INS2,IGF2,YWHAH,INSR,SOCS2,IGF1,IGF2A,SOCS1,IGF3 |
| corticotropin-releasing hormone receptor 1 binding | GNAO1A,GNAO1,CRH,UCN,GNAO1B |
| ionotropic glutamate receptor binding | CANX,DLG2,NETO1,DLG1L,SHANK3,SHANK1,DRD2,IL1R1,ADRB2,DLG4 |
| beta-2 adrenergic receptor binding | BDKRB2,NEDD4,SLC9A3R1,PDE4D |
| signal transducer activity | IKBKG,STAT5A,TAS2R200.2,ADRB2A,NPY8BR,TAAR8C,VALOPA,ZP3,GPR183B,DRD4-RS |
| G-protein beta/gamma-subunit complex binding | CETN2,GNA15,GNAQ,GNA13B,GNAI3,CETN1,GNA13A,GNA15.4,GNAI2A,Adcy4 |
Interacting Protein
Gnas has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gnas here. Most of them are supplied by our site. Hope this information will be useful for your research of Gnas.
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References
- Zeng, WH; Xu, JJ; et al. Pseudohypoparathyroidism with Hashimoto's thyroiditis and Turner syndrome: a case report. GYNECOLOGICAL ENDOCRINOLOGY 30:694-696(2014).
- Pierce, M; Sandrock, R; et al. Measurement of thyroid stimulating immunoglobulins using a novel thyroid stimulating hormone receptor-guanine nucleotide-binding protein, (GNAS) fusion bioassay. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 170:115-121(2012).
