Recombinant Full Length Human GNAS Protein, GST-tagged
Cat.No. : | GNAS-5336HF |
Product Overview : | Human GNAS full-length ORF ( NP_000507.1, 1 a.a. - 394 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5 exons. Some transcripts contains a differentially methylated region (DMR) at their 5 exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 72.1 kDa |
Protein Length : | 394 amino acids |
AA Sequence : | MGCLGNSKTEDQRNEEKAQREANKK IEKQLQKDKQVYRATHRLLLLGAGE SGKSTIVKQMRILHVNGFNGEGGEE DPQAARSNSDGEKATKVQDIKNNLK EAIETIVAAMSNLVPPVELANPENQ FRVDYILSVMNVPDFDFPPEFYEHA KALWEDEGVRACYERSNEYQLIDCA QYFLDKIDVIKQADYVPSDQDLLRC RVLTSGIFETKFQVDKVNFHMFDVG GQRDERRKWIQCFNDVTAIIFVVAS SSYNMVIREDNQTNRLQEALNLFKS IWNNRWLRTISVILFLNKQDLLAEK VLAGKSKIEDYFPEFARYTTPEDAT PEPGEDPRVTRAKYFIRDEFLRIST ASGDGRHYCYPHFTCAVDTENIRRV FNDCRDIIQRMHLRQYELL |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | GNAS GNAS complex locus [ Homo sapiens ] |
Official Symbol : | GNAS |
Synonyms : | GNAS; GNAS complex locus; GNAS1, guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; protein ALEX; GNASXL; GPSA; NESP; NESP55; SCG6; secretogranin VI; extra large alphas protein; neuroendocrine secretory protein; guanine nucleotide regulatory protein; alternative gene product encoded by XL-exon; adenylate cyclase-stimulating G alpha protein; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; AHO; GSA; GSP; POH; GNAS1; PHP1A; PHP1B; PHP1C; C20orf45; MGC33735; |
Gene ID : | 2778 |
mRNA Refseq : | NM_000516 |
Protein Refseq : | NP_000507 |
MIM : | 139320 |
UniProt ID : | O95467 |
Products Types
◆ Recombinant Protein | ||
GNAS-3762M | Recombinant Mouse GNAS Protein, His (Fc)-Avi-tagged | +Inquiry |
GNAS-2754H | Recombinant Human GNAS Protein, His-tagged | +Inquiry |
Gnas-3259M | Recombinant Mouse Gnas Protein, Myc/DDK-tagged | +Inquiry |
GNAS-5048H | Recombinant Human GNAS Protein, GST-tagged | +Inquiry |
GNAS-999H | Recombinant Human GNAS Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
GNAS-5866HCL | Recombinant Human GNAS 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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