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GNE

Official Full Name

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Overview

The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.
Synonyms

GNE; glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase; IBM2, UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; Uae1; IBM2; 2310066H07Rik; Bifunctional UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase; DMRV; ManAc kinase; N acylmannosamine kinase; NM; RP23-209M8.6; UDP GlcNAc 2 epimerase; UDP GlcNAc 2 epimerase/ManAc kinase; Uridine diphosphate N acetylglucosamine 2 epimerase; N-acylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase; GLCNE;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GNE-13359H	Recombinant Human GNE, His-tagged	E.coli	His	376-722a.a.	$319 / 25ug
Human	GNE-94H	Recombinant Human GNE, His-tagged	HEK293	His		Inquiry
Human	GNE-5858HCL	Recombinant Human GNE 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GNE-5061H	Recombinant Human GNE Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GNE-6082H	Recombinant Human GNE Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	GNE-5383HF	Recombinant Full Length Human GNE Protein, GST-tagged	In Vitro Cell Free System	GST	722 amino acids	Inquiry
Rat	GNE-2605R	Recombinant Rat GNE Protein	Mammalian Cell	His		Inquiry
Rat	GNE-2260R	Recombinant Rat GNE Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GNE-2260R-B	Recombinant Rat GNE Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	GNE-11130Z	Recombinant Zebrafish GNE	Mammalian Cell	His		Inquiry
Chicken	GNE-3081C	Recombinant Chicken GNE	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GNE Related Articles
GNE Related Research Area

GNE involved in several pathways and played different roles in them. We selected most pathways GNE participated on our site, such as Amino sugar and nucleotide sugar metabolism, Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Amino sugar and nucleotide sugar metabolism	GMDS;HKDC1;UAP1;UGP2A;MPI;CMASA;GPI1;CHIA.4;GALE
Asparagine N-linked glycosylation	NAPB;TRAPPC6BL;TRAPPC10;TRAPPC6B;DPAGT1;DERL2;SERPINA1L;GOLGA2;MAGT1
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	ST8SIA2;MPDU1;MPDU1A;ALG10B;ALG2;ST6GALNAC2;GNE;NEU4;SLC35A1
Metabolic pathways	HYAL3;IL4I1;RPN1;NAMPTB;GLSA;ATP6V0C;ATP6V0B;GANAB;SDSL
Metabolism of proteins	KDELR3;MPDU1B;ST3GAL3A;TRAPPC9;ALG14;CEACAM21;MIA3;NEU4;ADAMTSL3
Post-translational protein modification	TRAPPC4;NSMCE1;TRAPPC6BL;TMED10;PREB;SEC16B;MUCL1;NEU4;C8orf84
Sialic acid metabolism	NANP;SLC35A1;ST6GALNAC1.2;ST6GAL2B;ST8SIA3;ST6GALNAC2;GNE
Synthesis of substrates in N-glycan biosythesis	ST6GAL2B;ST8SIA3;ST6GALNAC2;SLC35A1;GNE;ST6GALNAC1.2

GNE has several biochemical functions, for example, ATP binding, N-acylmannosamine kinase activity, UDP-N-acetylglucosamine 2-epimerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNE itself. We selected most functions GNE had, and list some proteins which have the same functions with GNE. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	TPK1;HSPE1;CAMKK1;MYHZ1.1;CKBB;EPHA7;PMS2;PIK3R4;RFC5
N-acylmannosamine kinase activity	NAGK;GNE
UDP-N-acetylglucosamine 2-epimerase activity
hydrolase activity, hydrolyzing O-glycosyl compounds	GBE1;LCTLB;CHIA.1;KIAA1161;CHIA.4;LCTL;CHIA.3;KLB;Chil3
metal ion binding	ASGR1;ZNF597;GALNTL2;FLYWCH1;GRIN2A;LNX2;STAMBPA;MGRN1A;ADAT1
protein binding	MYO6;TRIM26;GNG5;SLU7;CIDEB;GYPC;MCM10;PAK3;KLK4

GNE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNE here. Most of them are supplied by our site. Hope this information will be useful for your research of GNE.

SPRY2; KRTAP5-9; KRTAP10-5; KRTAP10-7; KRTAP10-8; KRTAP10-9

Weldon, RA; Fensin, ML; et al. Total neutron emission generation and characterization for a Next Generation Safeguards Initiative spent fuel library. PROGRESS IN NUCLEAR ENERGY 80:45-73(2015).

Broccolini, A; Mirabella, M; et al. Hereditary inclusion-body myopathies. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:644-650(2015).

Carbohydrate Kinases