GNGT1
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Official Full Name
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -
Overview
Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by;transmembrane receptors to effector proteins. Transducin is a guanine nucleotide-binding protein found specifically in;rod outer segments, where it mediates activation by rhodopsin of a cyclic GTP-specific (guanosine monophosphate);phosphodiesterase. Transducin is also referred to as GMPase. GNGT1 encodes the gamma subunit of transducin (Hurley et;al., 1984 (PubMed 6438626); Scherer et al., 1996 (PubMed 8661128)). -
Synonyms
GNGT1;guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1;guanine nucleotide-binding protein G(T) subunit gamma-T1;GNG1;G gamma 1;Guanine nucleotide binding protein G;Transducin gamma chain
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- DDK
- Myc
- Avi
- Fc
- GST
Involved Pathway
GNGT1 involved in several pathways and played different roles in them. We selected most pathways GNGT1 participated on our site, such as Ras signaling pathway,Chemokine signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNGT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | PLA2G4A,ABL2,PAK6,PLA2G2F,PRKACA,PTPN11,SHOC2,FIGF,RAP1B,GNG4 |
| PIK-Akt signaling pathway | PPP2R1B,GNG7,YWHAZ,PKN1,PDGFRA,G6PC,FGFR4,SOS1,Kitl,CCND1 |
| Pathways in cancer | AXIN1,SMAD4,TCEB1,FGFR3,GNG13,FGF2,MMP2,FGF1,WNT3A,Pdgfa&Pdgfb |
| Alcoholism | HIST1H2BI,SHC1,HIST1H2AM,HIST1H3A,HIST1H2AB,RAF1,PPP1CC,H2AFX,HIST1H2BD,HIST2H4 |
| Cholinergic synapse | PRKCB,GNAI1,PIK3CG,CHRM5,MAPK1,KCNJ12,CREB3L4,GNG5,PLCB1,CHRNA7 |
| GABAergic synapse | SLC38A1,GABARAP,GABBR1,GNAI1,GABRR1,GAD1,GNG13,GABRA5,GABRG1,GLUL |
| Chemokine signaling pathway | NRAS,ADRBK2,JAK3,GM1987,CX3CR1,MAP2K1,CCL15,WAS,GNB2,CXCR4 |
| Circadian entrainment | GRIA3,PRKCG,GNG10,CACNA1H,PRKACB,GRIA2,PLCB4,CACNA1G,GNB4,MAPK1 |
| Retrograde endocannabinoid signaling | GNB2,MAPK8,GABRB3,GABRA3,GABRB2,GNAI2,FAAH,DAGLB,GNG7,GRM1 |
Protein Function
GNGT1 has several biochemical functions, for example, GTPase activity,protein binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNGT1 itself. We selected most functions GNGT1 had, and list some proteins which have the same functions with GNGT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | TAS2R134,VMN1R43,IL1R1,OLFCG4,GNA13A,PTK2,SLC20A1,DRD2A,FLNA,TAAR14A |
| protein binding | PARP1,ASB6,FRMD8,TTC37,TREX1,NR4A2,C6,CBFA2T2,GRK6,ISL1 |
| GTPase activity | TUBB2B,RRAGCA,GNA11B,EEF2A.2,RASD1,GUF1,GNAI3,GNAS,TUBB4B,RHOU |
Interacting Protein
GNGT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNGT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNGT1.
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References
- Lagman, D; Sundstrom, G; et al. Expansion of transducin subunit gene families in early vertebrate tetraploidizations. GENOMICS 100:203-211(2012).
- Mulligan, T; Farber, SA; et al. Central and C-terminal domains of heterotrimeric G protein gamma subunits differentially influence the signaling necessary for primordial germ cell migration. CELLULAR SIGNALLING 23:1617-1624(2011).
