• Official Full Name

    glycosylphosphatidylinositol specific phospholipase D1

  • Overview

    Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]
  • Synonyms

    GPLD1; glycosylphosphatidylinositol specific phospholipase D1; PLD; GPIPLD; PIGPLD; GPIPLDM; PIGPLD1; phosphatidylinositol-glycan-specific phospholipase D; GPI-PLD; PI-G PLD; GPI-specific phospholipase D; glycoprotein phospholipase D; glycosylphosphatidylinositol specific phospholipase D1, isoform 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian cells
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GPLD1-27985TH Recombinant Human GPLD1 Wheat Germ N/A 176 amino acids
Human GPLD1-13427H Recombinant Human GPLD1, His-tagged E.coli His 1-176a.a.
Human GPLD1-735HCL Recombinant Human GPLD1 cell lysate N/A
Human GPLD1-2250H Recombinant Human GPLD1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GPLD1-2251H Recombinant Human GPLD1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human GPLD1-5160H Recombinant Human GPLD1 Protein, GST-tagged Wheat Germ GST
Human GPLD1-172H Recombinant Human GPLD1 Protein, His-tagged E.coli His Thr725~Thr1074
Human GPLD1-5549HF Recombinant Full Length Human GPLD1 Protein, GST-tagged In Vitro Cell Free System GST 176 amino acids
Human GPLD1-01H Recombinant Human GPLD1 Protein, DYKDDDDK-tagged Human Cell DYKDDDDK
Human GPLD1-1383H Recombinant Human GPLD1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GPLD1-434H Recombinant Human GPLD1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human GPLD1-207HF Recombinant Full Length Human GPLD1 Protein In Vitro Cell Free System 176 amino acids
Human GPLD1-419HFL Recombinant Full Length Human GPLD1 Protein, C-Flag-tagged Mammalian cells Flag
Human GPLD1-1011H Recombinant Human GPLD1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GPLD1-1011H-B Recombinant Human GPLD1 Protein Pre-coupled Magnetic Beads HEK293
Human GPLD1-2980H Recombinant Human GPLD1 Protein (Met496-Asp840), N-His tagged E.coli N-His Met496-Asp840
Mouse Gpld1-1047M Recombinant Mouse Gpld1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

GPLD1 involved in several pathways and played different roles in them. We selected most pathways GPLD1 participated on our site, such as Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPLD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycosylphosphatidylinositol(GPI)-anchor biosynthesisGPLD1;PIGV;PIGB;PIGH;PIGS;PIGM;PIGK;PIGA;PIGN

GPLD1 has several biochemical functions, for example, glycosylphosphatidylinositol phospholipase D activity, phospholipase D activity, sodium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPLD1 itself. We selected most functions GPLD1 had, and list some proteins which have the same functions with GPLD1. You can find most of the proteins on our site.

Function Related Protein
glycosylphosphatidylinositol phospholipase D activity
phospholipase D activityPLD2;PLD3;HMOX1;GPLD1;PLD4;PLD1;PLD1A
sodium channel regulator activitySCN1BB;RANGRF;SGK2A;PRSS30;SGK3;SCLT1;SGK2B;NOS1;FGF12

GPLD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPLD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPLD1.

Research Area

Related articles

Sanjabi, B; Dashty, M; et al. Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes. SCIENTIFIC REPORTS 5:-(2015).
Deeg, MA; Xuei, XL; et al. Genetic variation of GPLD1 associates with serum GPI-PLD levels: A preliminary study. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1821:381-385(2012).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does GPLD1 interact with other enzymes in carbohydrate and lipid metabolism? 12/10/2022

GPLD1 works with other metabolic enzymes, coordinating carbohydrate and lipid metabolism.

What potential therapeutic applications arise from targeting GPLD1 in metabolic diseases? 02/27/2022

Targeting GPLD1 offers potential in treating metabolic disorders by regulating liver metabolism.

What role does GPLD1 play in lipid metabolism? 02/28/2021

GPLD1 is also involved in lipid metabolism, affecting fat processing and storage.

What is the impact of altered GPLD1 activity on metabolic disorders? 10/22/2020

Altered GPLD1 activity is linked to various metabolic disorders, including diabetes and liver diseases.

What is the primary role of GPLD1 in liver function? 10/27/2018

GPLD1, a glycosylphosphatidylinositol-specific phospholipase, is involved in modulating liver metabolism and function.

How do genetic variations in GPLD1 affect liver health? 08/26/2018

Genetic variations in GPLD1 can lead to altered metabolic processing, impacting liver health and function.

How does GPLD1 contribute to glycogen metabolism? 07/17/2017

It plays a role in glycogen metabolism, impacting glucose regulation in the liver.

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