GRM3

  • Official Full Name

    glutamate receptor, metabotropic 3

  • Overview

    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
  • Synonyms

    Grm3; glutamate receptor, metabotropic 3; mGluR3; metabotropic glutamate receptor 3; Gprc1c, Mglur3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRM3-29610TH Recombinant Human GRM3 protein Wheat Germ N/A
Human GRM3-1941H Recombinant Human GRM3 protein, His & GST-tagged E.coli His/GST Asp568~Phe819 (Accession# Q14832)
Human GRM3-29609TH Recombinant Human GRM3 Wheat Germ N/A 100 amino acids
Human GRM3-5735HCL Recombinant Human GRM3 293 Cell Lysate HEK293 N/A
Human GRM3-5366H Recombinant Human GRM3 Protein, GST-tagged Wheat Germ GST
Human GRM3-599HF Recombinant Full Length Human GRM3 Protein In Vitro Cell Free System 879 amino acids
Human GRM3-1141HFL Recombinant Human GRM3 protein, His&Flag-tagged HEK293 His&Flag 1-879 aa
Human GRM3-2549H Recombinant Human GRM3 Protein (Asp568-Phe819), N-GST tagged E.coli N-GST Asp568-Phe819
Mouse GRM3-7286M Recombinant Mouse GRM3 Protein Mammalian Cell His
Mouse GRM3-3941M Recombinant Mouse GRM3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GRM3-3941M-B Recombinant Mouse GRM3 Protein Pre-coupled Magnetic Beads HEK293
Rat GRM3-2715R Recombinant Rat GRM3 Protein Mammalian Cell His
Rat GRM3-2369R-B Recombinant Rat GRM3 Protein Pre-coupled Magnetic Beads HEK293
Rat GRM3-2369R Recombinant Rat GRM3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish GRM3-6856Z Recombinant Zebrafish GRM3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

GRM3 involved in several pathways and played different roles in them. We selected most pathways GRM3 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Phospholipase D signaling pathwayPIP5K1B;AGPAT4;PIK3CD;INS1;PTGFR;LPAR4;PIK3R3;GRM1;RALB
Neuroactive ligand-receptor interactionTBXA2R;GRIK1;PTGER1A;GRM6;RXFP2A;MC5R;ADORA2AB;GRM4;GABRA6
Glutamatergic synapsePPP3R1;GNB3;GRIK4;GNG3;GRIN2B;GRM7;SLC38A2;GRM5;ITPR1
Cocaine addictionCREB3L1;GRIN2B;GRIN2D;CREB3;DRD1;DDC;RELA;CREB3L4;GRIN1

GRM3 has several biochemical functions, for example, G-protein coupled receptor activity, calcium channel regulator activity, glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM3 itself. We selected most functions GRM3 had, and list some proteins which have the same functions with GRM3. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityOLFR24;HTR1AA;OLFR502;LPAR2A;OR51B5;GPR186;APLNR;DRD7;HCAR1-2
calcium channel regulator activityGNB2;CACNB2;TSPAN13A;CACNA2D2;STIM1A;SRI;SGK2;GRM2A;CAV3
glutamate receptor activityGRIK5;GRM5;GRM4;GRM1;GRIA1;GRM8;GRM6;GRID2;GRIK3
group II metabotropic glutamate receptor activityGRM3;GRM2A;GRM2
NOT group III metabotropic glutamate receptor activity

GRM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM3.

Gene Family

GPCRs

Research Area

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