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Official Full Name glutamate receptor, metabotropic 8
Background L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms GRM8; glutamate receptor, metabotropic 8; metabotropic glutamate receptor 8; GLUR8; GPRC1H; mGlu8; MGLUR8; FLJ41058; Glutamate receptor metabotropic 8; GRM8_HUMAN; MGC126724; MGR8; OTTHUMP00000024506; OTTHUMP00000069010; OTTHUMP00000199504; OTTHUMP00000212423
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRM8-13546H Recombinant Human GRM8, His-tagged E.coli His
    Human GRM8-28274TH Recombinant Human GRM8 Wheat Germ N/A
    Human GRM8-5374H Recombinant Human GRM8 Protein, GST-tagged Wheat Germ GST
    Human GRM8-5731HCL Recombinant Human GRM8 293 Cell Lysate HEK293 N/A
    Rat GRM8-2719R Recombinant Rat GRM8 Protein Mammalian Cell His
    Rhesus Macaque GRM8-1978R Recombinant Rhesus monkey GRM8 Protein, His-tagged Mammalian Cell His

    grm8 involved in several pathways and played different roles in them. We selected most pathways grm8 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with grm8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phospholipase D signaling pathway PIP5K1B; F2R; PLA2G4D; PIP5K1C; PIP5K1A; PLA2G4C; CYTH2; PLCB1; SHC1; PDGFA
    Neuroactive ligand-receptor interaction GH2; LEPR; TAAR12I; P2RX2; OPRL1; MC2R; GRIK1; TAAR12H; CHRNB3A; TRPV1
    Glutamatergic synapse GRIK4; PPP3CC; GNAI3; GRM2; GRIN1; GRIK3; GRM1; GNAI2; GRIK1; GNB1

    grm8 has several biochemical functions, for example, G-protein coupled receptor activity, glutamate receptor activity, group III metabotropic glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by grm8 itself. We selected most functions grm8 had, and list some proteins which have the same functions with grm8. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor activity CXCR4A; VMN1R54; TAS2R116; P2RY6; TAAR15; FZD3B; GRM8; TAAR12A; GHSR; OPRM1
    glutamate receptor activity GRM6; GRID2; GRM1; GRM7; GRM4; GRM2; GRM8; GRIA1; GRM3; GRM5
    group III metabotropic glutamate receptor activity GRM8; GRM7; GRM6B; GRM6; GRM6A; GRM4

    grm8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with grm8 here. Most of them are supplied by our site. Hope this information will be useful for your research of grm8.

    Yang, XR; Zhang, Y; et al. Involvement of group III metabotropic glutamate receptors in the modulation of spinal nociceptive signals. NEURAL REGENERATION RESEARCH 4:443-448(2009).

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