gys2 Protein, glycogen synthase 2 (liver)


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Official Full Name glycogen synthase 2 (liver)
Background The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content.
Synonyms GYS2; glycogen synthase 2 (liver); glycogen [starch] synthase, liver; Glycogen starch synthase liver; EC; Glycogen synthase 2 liver
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GYS2-4514H Recombinant Human GYS2 protein, His-tagged E.coli His
    Human GYS2-13635H Recombinant Human GYS2, His-tagged E.coli His
    Human GYS2-4513H Recombinant Human GYS2 Protein, GST-tagged Wheat Germ GST
    Human GYS2-5669HCL Recombinant Human GYS2 293 Cell Lysate HEK293 N/A
    Mouse GYS2-7408M Recombinant Mouse GYS2 Protein Mammalian Cell His
    Rat GYS2-2769R Recombinant Rat GYS2 Protein Mammalian Cell His
    Zebrafish GYS2-2672Z Recombinant Zebrafish GYS2 Mammalian Cell His

    gys2 involved in several pathways and played different roles in them. We selected most pathways gys2 participated on our site, such as Starch and sucrose metabolism, PIK-Akt signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with gys2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Starch and sucrose metabolism UXS1; UGP2; UGT1A6A; AMY2A; HK3; GYS2; UGT2A3; PGM2L1; PGM1; G6PCA.1
    PIK-Akt signaling pathway FN1; IL3RA; PCK1; IFNA6; GSK3B; BRCA1; PPP2R2A; GNG5; FLT1; FGF7
    AMPK signaling pathway IRS1; PPP2R3A; HNF4A; SCD5; PFKL; PPP2CB; PPP2R5B; CPT1A; GYS2; MAP3K7
    Insulin signaling pathway TRIP10A; RPS6KB1; INS; PYGL; PPP1R3CB; PRKAB1A; AKT2; PDE3B; CALM4; PPP1CBL
    Glucagon signaling pathway PKM2; LDHAL6A; PPP3CC; PRKAA2; PYGL; GYS2; PLCB2; PPP3CB; ATF4; LDHA
    Insulin resistance PRKCE; G6PCA.2; PPP1CAB; CRTC2; NFKBIAB; MGEA5; PPP1R3CA; PPP1R3DA; PPP1CAA; IL6

    gys2 has several biochemical functions, for example, glycogen (starch) synthase activity, glycogen synthase activity, transferring glucose-1-phosphate, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by gys2 itself. We selected most functions gys2 had, and list some proteins which have the same functions with gys2. You can find most of the proteins on our site.

    Function Related Protein
    glycogen (starch) synthase activity GYS1; GYS2
    glycogen synthase activity, transferring glucose-1-phosphate GYS1; GYS2
    protein homodimerization activity DMRT3A; LRRK2; GOT2; ASCL1; SMAD1; GM5506; MSH2; Defa-rs7; APOA4; PRKG2

    gys2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gys2 here. Most of them are supplied by our site. Hope this information will be useful for your research of gys2.


    Lau, MY; Han, H; et al. Association of cyclin D and estrogen receptor alpha 36 with hepatocellular adenomas of female mice under chronic endoplasmic reticulum stress. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 28:576-583(2013).
    Vadrot, N; Ghanem, S; et al. Mitochondrial DNA Maintenance Is Regulated in Human Hepatoma Cells by Glycogen Synthase Kinase 3 beta and p53 in Response to Tumor Necrosis Factor alpha. PLOS ONE 7:-(2012).

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