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HARS2

  • Official Full Name

    histidyl-tRNA synthetase 2, mitochondrial (putative)

  • Overview

    Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter.
  • Synonyms

    HARS2; histidyl-tRNA synthetase 2, mitochondrial (putative); HARSL, histidyl tRNA synthetase like; probable histidyl-tRNA synthetase, mitochondrial; HARSR; histidine tRNA ligase 2; mitochondrial (putative); HO3; Harsl; 4631412B19Rik; AI593507; HARS 2; HARS related; HisRS; Histidine translase; Histidine tRNA ligase; Histidine tRNA ligase homolog; Histidine tRNA ligase like; Histidyl tRNA synthetase 2 mitochondrial; Histidyl tRNA synthetase like; Probable histidyl tRNA synthetase mitochondrial; HARS-related; histidine-tRNA ligase homolog; histidine tRNA ligase 2, mitochondrial (putative);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HARS2-4582H Recombinant Human HARS2 Protein, GST-tagged Wheat Germ GST
Human HARS2-13670H Recombinant Human HARS2, GST-tagged E.coli GST C-term-350a.a.(C-164a.a.)
Human HARS2-5634HCL Recombinant Human HARS2 293 Cell Lysate HEK293 N/A
Human HARS2-546H Recombinant Human HARS2 Protein (34-506 aa), His-SUMO-tagged E.coli His/SUMO 34-506 aa
Human HARS2-2228H Recombinant Human HARS2 Protein, His-tagged E.coli N-His Lys231-Ser506
Human HARS2-2177HFL Recombinant Full Length Human HARS2 Protein, C-Flag-tagged Mammalian cells Flag
Human HARS2-1044H Recombinant Human HARS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HARS2-1044H-B Recombinant Human HARS2 Protein Pre-coupled Magnetic Beads HEK293
Mouse HARS2-7484M Recombinant Mouse HARS2 Protein Mammalian Cell His
Mouse HARS2-4059M-B Recombinant Mouse HARS2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Hars2-3357M Recombinant Mouse Hars2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Hars2-1616M Recombinant Mouse Hars2 Protein, His-tagged E.coli N-His Asn212-Ser505
Mouse HARS2-4059M Recombinant Mouse HARS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HARS2 Related Articles

HARS2 involved in several pathways and played different roles in them. We selected most pathways HARS2 participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HARS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aminoacyl-tRNA biosynthesisSARS2;VARS2;WARS;FARSB;RARS2;MTFMT;HARS2;HARS;PET112L

HARS2 has several biochemical functions, for example, ATP binding, histidine-tRNA ligase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HARS2 itself. We selected most functions HARS2 had, and list some proteins which have the same functions with HARS2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTYK2;CAMK1GB;CAMK2B1;NLRP2;NEK7;MCMDC2;MYLK4;MCM2;AURKC
histidine-tRNA ligase activityHARS;HARS2
poly(A) RNA bindingNLRP11;RPS2;HMGB3;FCF1;SFRS9;C4BPA;ZCCHC11;MRPS15;RBM15
protein bindingKCNA1;USHBP1;NFIX;LCAT;RPS27A;SNX15;EIF3E;EIF4EBP3L;EIF2B4
protein homodimerization activityADH5;APOA4;ANO2;UXS1;STK25;JUP;BIRC5;ERN1;TYR

HARS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HARS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HARS2.

AGTRAP; gag; BST2; ssrna_ug; AURKA; ORC1; ICT1; GTF2H5; VPS16

Badura-Stronka, M; Wawrocka, A; et al. Severe manifestation of Leber's hereditary optic neuropathy due to 11778G > A mtDNA mutation in a female with hypoestrogenism due to Perrault syndrome. MITOCHONDRION 13:831-834(2013).
Jenkinson, EM; Rehman, AU; et al. Perrault Syndrome Is Caused by Recessive Mutations in CLPP, Encoding a Mitochondrial ATP-Dependent Chambered Protease. AMERICAN JOURNAL OF HUMAN GENETICS 92:605-613(2013).
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