HLA-C Protein


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Official Full Name HLA-C major histocompatibility complex, class I, C [ Homo sapiens ]
Background HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
Synonyms major histocompatibility complex, class I, C; 4933; Ensembl:ENSG00000204525; FLJ27082; HLA class I histocompatibility antigen, Cw-1 alpha chain; MHC class I antigen heavy chain HLA-C; human leukocyte antigen-C alpha chain; major histocompatibility antigen HLA-C; HLA class I histocompatibility antigen, C alpha chain; HLC-C; D6S204; PSORS1; HLA-JY3
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-C-13811H Recombinant Human HLA-C, GST-tagged E.coli GST
    Human HLA-C-242H Recombinant Human HLA-C Protein, His-tagged E.coli His
    Human HLA-C-268H Recombinant Human major histocompatibility complex, class I, C, His-tagged E.coli His
    Human HLA-C-269H Recombinant Human HLA-C protein, His-tagged HEK293 His
    Human HLA-C-4834H Recombinant Human HLA-C Protein, GST-tagged Wheat Germ GST
    Human HLA-C-5498HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    HLA-C involved in several pathways and played different roles in them. We selected most pathways HLA-C participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) HLA-DPB1; OCLN; NRXN1A; SELE; HLA-DOA; SDC2; MHC2DAB; CD40LG; JAM2A; CD8A
    Antigen processing and presentation HSPA8; KLRC3; CD8B; HLA-DPA1; LGMN; HSPA1B; HSPA1L; HLA-DRB5; HLA-B; CTSS
    Natural killer cell mediated cytotoxicity SH2D1A; TNFRSF10B; PTPN11; RAET1L; IFNA4; ARAF; FYN; TYROBP; PPP3CC; IFNG
    Type I diabetes mellitus FAS; PRF1; HLA-DRB3; HLA-DMB; HLA-DMA; IFNG; H2-Q10; GZMB; HLA-DPB1; HLA-G
    HTLV-I infection WNT7A; MRAS; HLA-E; H2-Q10; PIK3R2; NFKB2; RANBP3; POLD2; CDC26; NFYB
    Herpes simplex infection SRSF6B; EP300; MAVS; C1QBP; EIF2S1B; CLOCK; TAF4B; IL12B; Casp3; MYD88
    Epstein-Barr virus infection CCNA1; SNW1; CD58; MAPK13; NEDD4; VIM; SKP2; POLR3GL; AKT1; CSNK2B
    Viral carcinogenesis GTF2H3; PIK3R1; TBP; YWHAG; CDC42; EIF2AK2; KAT2A; HLA-A; ACTN2; HIST1H2BB
    Autoi HLA-F; Ifna11; HLA-B; IFNA12; IFNA8; TSHR; HLA-G; CD86; IL4; IL5
    ne thyroid disease HLA-DMB; CD86; CD28; FASLG; TG; HLA-DRA; Fasl; H2-AB1; HLA-DQB1; HLA-DRB1
    Allograft rejection FASLG; GZMB; Il2; HLA-DRB3; CD40; HLA-DOB; HLA-DRB1; IL4; HLA-F; Fasl
    Graft-versus-host disease HLA-DPB1; HLA-F; KLRC1; KIR2DL3; HLA-DQA2; HLA-A; KIR2DL1; HLA-DQB1; PRF1; HLA-DRB3
    Viral myocarditis HLA-DPA1; BID; PRF1; SGCD; H2-Q10; CASP8; HLA-DRB5; CD80; CAV1; CCND1

    HLA-C has several biochemical functions, for example, TAP binding, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-C itself. We selected most functions HLA-C had, and list some proteins which have the same functions with HLA-C. You can find most of the proteins on our site.

    Function Related Protein
    TAP binding HLA-B; HLA-C; HLA-A; H2-Q10
    peptide antigen binding H2-AA; HLA-DRB4; MHC1UKA; DHCR24; MHC1UBA; MHC1UJA; HLA-G; MHC1UDA; HLA-F; MHC1ZBA

    HLA-C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-C here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-C.

    Law, MG; Achhra, A; et al. Clinical and demographic factors associated with low viral load in early untreated HIV infection in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial. HIV MEDICINE 16:37-45(2015).
    Mahil, SK; Capon, F; et al. Genetics of Psoriasis. DERMATOLOGIC CLINICS 33:1-+(2015).

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