| Official Full Name | major histocompatibility complex, class II, DM alpha |
| Background | HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. |
| Synonyms | HLA-DMA; major histocompatibility complex, class II, DM alpha; HLA class II histocompatibility antigen, DM alpha chain; D6S222E; RING6; MHC class II antigen DMA; really interesting new gene 6 protein; class II histocompatibility antigen, M alpha chain; DM |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
HLA-DMA involved in several pathways and played different roles in them. We selected most pathways HLA-DMA participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DMA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | DYNC1LI1; TUBA4L; TUBB6; RILP; FCGR3B; PIKFYVE; TFRC; ATP6V0A1A; CTSL1B; ATP6V1B1 |
| Cell adhesion molecules (CAMs) | CDH4; HLA-DQB1; SDC4; VTCN1; CD8B1; CLDNJ; CD40LG; NCAM2; JAM3; BMA1 |
| Antigen processing and presentation | RFX5; KLRC1; TAP1; IFNG; RFXAP; HLA-A; B2M; HLA-DMA; HLA-DQA2; KIR2DL3 |
| Intestinal i | HLA-DOA; Icosl; HLA-DQA2; CD40LG; CD28; H2-AA; ICOS; MHC2DAB; TNFRSF17; AICDA |
| ne network for IgA production | TGFB1; IL4; CCL28; HLA-DOB; IL5; HLA-DRA; CCR10; ITGB7; BLB1; PIGR |
| Type I diabetes mellitus | CPE; PRF1; IL1B; HLA-DQA2; ICA1; GAD1; HLA-DRB1; HLA-B; HLA-DOB; PTPRN |
| Leishmaniasis | MAPK12; FCGR1; MAPK3; FCGR3B; ITGAM; IL1B; ITGB1; CYBA; NFKBIB; TGFB2 |
| Toxoplasmosis | MAPK10; LY96; IL12A; BCL2L1; MAP3K7; BCL2; PIK3R3; TLR2; RELA; MAP2K6 |
| Staphylococcus aureus infection | SELP; FCGR3; ITGB2; C4A; HLA-DRB5; C1QB; MBL2; FGG; FCGR4; C1S |
| Tuberculosis | MRC1; H2-AB1; cgr2b; BAX; IL1A; H2-AA; CALML5; FCGR2B; BAD; MAPK11 |
| Influenza A | NUP98; IFNGR2; IRAK4; MAP2K3; HLA-DMB; IFNG; IL12B; HLA-DQA1; NXT2; IL1A |
| HTLV-I infection | BAX; NFKB1; POLE3; CCND2; WNT16; PDGFRB; LTBR; PIK3R1; HLA-DOB; ATF1 |
| Herpes simplex infection | TRAF1; IL15; PVRL1B; IFNPHI1; SP100; HLA-C; TNFB; BMA2; PILRA; OAS3 |
| Asthma | HLA-DMB; HLA-DPA1; CD40LG; HLA-DQA2; HLA-DRB1; IL5; IL9; IL10; HLA-DMA; HLA-DRB4 |
| Autoi | H2-AB1; CD80; CD40LG; IFNA12; Il2; HLA-DQB1; HLA-DRB1; TSHB; HLA-DQA1; HLA-DMB |
| ne thyroid disease | H2-Q10; HLA-DRA; HLA-DQB1; TG; TSHB; HLA-DRB4; Ifna11; HLA-B; IFNA8; IFNA12 |
| Inflammatory bowel disease (IBD) | HLA-DRB5; IL6; IL1A; HLA-DQB1; IL17F; HLA-DOA; IL13; Il23a; Il4ra; IFNGR2 |
| Systemic lupus erythematosus | HIST1H2BQ; HIST1H2BK; HIST1H2AM; TRIM21; FCGR1; HLA-DRB4; HIST1H2AJ; FCGR3B; HIST1H2AK; H2AFY2 |
| Rheumatoid arthritis | ITGB2L; CCL3L3; FLT1; HLA-DOB; ATP6V0E2; IL15; ICAM1; HLA-DQA2; TNFSF13; ITGB2 |
| Allograft rejection | HLA-G; HLA-DOB; CD40; HLA-DMB; Il2; HLA-DRB1; FAS; HLA-B; HLA-DRB4; HLA-DMA |
| Graft-versus-host disease | KIR3DL2; HLA-DRB4; HLA-DRB1; GZMB; HLA-DMB; TNF; HLA-C; FAS; HLA-F; HLA-DRB3 |
| Viral myocarditis | HLA-DQA2; HLA-DRB3; ABL1; CD86; HLA-DPB1; HLA-E; HLA-A; EIF4G2; HLA-DOA; RAC1 |
HLA-DMA has several biochemical functions, for example, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DMA itself. We selected most functions HLA-DMA had, and list some proteins which have the same functions with HLA-DMA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class II protein complex binding | ATP1B1; HSPA8; HLA-DMA; HSP90AA1; HSP90AB1; HLA-DOA; HLA-DMB; HLA-DRA; PKM; MS4A1 |
HLA-DMA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DMA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DMA.
HLA-DRB1; HLA-DMB
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