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Official Full Name major histocompatibility complex, class II, DM alpha
Background HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Synonyms HLA-DMA; major histocompatibility complex, class II, DM alpha; HLA class II histocompatibility antigen, DM alpha chain; D6S222E; RING6; MHC class II antigen DMA; really interesting new gene 6 protein; class II histocompatibility antigen, M alpha chain; DM
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DMA-13812H Recombinant Human HLA-DMA, GST-tagged E.coli GST
    Human HLA-DMA-27713TH Recombinant Human HLA-DMA Wheat Germ N/A
    Human HLA-DMA-4836H Recombinant Human HLA-DMA Protein, GST-tagged Wheat Germ GST
    Human HLA-DMA-5499HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    hla-dma involved in several pathways and played different roles in them. We selected most pathways hla-dma participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with hla-dma were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome ITGB1B.2; RAB7B; CD209A; TUBA4L; C3; C1R; MRC2; TUBA8L; ACTB; LAMP1
    Cell adhesion molecules (CAMs) CLDN11B; CLDN7; CD8B1; CLDN8; NFASCA; ITGAM; H2-AA; MAG; CLDN7A; NEO1A
    Antigen processing and presentation TAP1; HSPA6; HLA-DPA1; HSP90AB1; HLA-DRA; CD4; HLA-DRB1; CTSB; H2-Q10; H2-AA
    Intestinal i TNFSF13; MHC2DEB; CD80; Il2; CXCL12B; HLA-DQB1; MHC2DAB; MHC2A; HLA-DRB3; HLA-DRA
    ne network for IgA production HLA-DMB; TNFRSF17; IL6; IL15; HLA-DRB4; TGFB1; MHC2DAB; CXCR4; HLA-DRA; HLA-DMA
    Type I diabetes mellitus IL12A; FASLG; HLA-DPB1; H2-AB1; HLA-DOB; CD80; HLA-E; HLA-F; HLA-DRB4; PRF1
    Leishmaniasis HLA-DRB4; FCGR3A; TNF; FCGR1; ELK1; ITGAM; IFNGR2; IFNG; H2-AB1; FCGR2A
    Toxoplasmosis HSPA6; STAT1; SOCS1; LAMB2; MAP3K7; MAPK10; NFKBIA; HLA-DRB3; MAPK11; MAPK12
    Staphylococcus aureus infection FCGR2A; PTAFR; C4A; GM5077; HLA-DOA; C5; C5AR1; H2-AB1; CFI; MBL1
    Tuberculosis Il23a; Il12b; RFX5; HLA-DRB1; TLR4; IFNA13; RELA; APAF1; ATP6V0C; NFYB; FCGR4
    Influenza A MAPK11; TLR3; TNFRSF1A; PRSS3; IFIH1; HNRNPUL1; LOC100033925; IFNA10; Fasl; NFKBIA
    HTLV-I infection POLD1; GM-CSF; RRAS2; NFATC4; CREM; ETS2; WNT3A; FZD5; LTBR; H2-Q10
    Herpes simplex infection TP53; MAVS; TAF6; MCRS1; CFP; STAT1B; PPP1CBL; IFNB1; NFKBIB; MAPK8B
    Asthma RNASE3; EPX; CD40LG; CCL11; HLA-DRA; IL10; IL9; HLA-DMA; IL13; TNF
    Autoi HLA-DRB1; HLA-DRA; HLA-DOB; H2-AA; IFNA16; HLA-DRB5; HLA-C; H2-AB1; IFNA7; Ifna11
    ne thyroid disease CD40LG; IFNA1; TPO; FAS; CD86; TSHB; IFNA6; TG; TSHR; IL4
    Inflammatory bowel disease (IBD) MAF; HLA-DRB4; H2-AA; HLA-DRA; IFNG; STAT3; RORA; STAT6; SMAD2; HLA-DRB1
    Systemic lupus erythematosus HIST1H2AI; H2AFX; HIST3H3; HIST1H3C; HLA-DQA2; CD40; GM14477; HIST1H2AO; Hc; GM14479
    Rheumatoid arthritis ATP6V0A2; TLR4; ICAM1; Ccl12; HLA-DQA2; CXCL12; ATP6V0A4; HLA-DRA; ATP6V1E2; HLA-DOB
    Allograft rejection CD28; IFNG; HLA-DQA1; MICA; HLA-DRB5; H2-Q10; HLA-DOB; IL5; HLA-C; H2-AB1
    Graft-versus-host disease HLA-DRB3; H2-AB1; HLA-A; H2-Q10; KIR3DL2; HLA-C; IFNG; KLRD1; HLA-B; CD80
    Viral myocarditis HLA-E; HLA-DRB1; H2-AB1; CD40LG; CASP8; HLA-DRB5; ACTB; HLA-DQA2; HLA-DOA; ICAM1

    hla-dma has several biochemical functions, for example, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hla-dma itself. We selected most functions hla-dma had, and list some proteins which have the same functions with hla-dma. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein complex binding ANXA11; PKM; CD74; HLA-DMB; HSP90AA1; HLA-DMA; ATP1B1; HLA-DRA; CD81; MS4A1

    hla-dma has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hla-dma here. Most of them are supplied by our site. Hope this information will be useful for your research of hla-dma.


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