HLA-DMA Protein

HLA-DMA

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HLA-DMA

Official Full Name major histocompatibility complex, class II, DM alpha
Background HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Synonyms HLA-DMA; major histocompatibility complex, class II, DM alpha; HLA class II histocompatibility antigen, DM alpha chain; D6S222E; RING6; MHC class II antigen DMA; really interesting new gene 6 protein; class II histocompatibility antigen, M alpha chain; DM
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DMA-4026H Recombinant Human HLA-DMA protein, His-tagged E.coli His
    Human HLA-DMA-13812H Recombinant Human HLA-DMA, GST-tagged E.coli GST
    Human HLA-DMA-27713TH Recombinant Human HLA-DMA Wheat Germ N/A
    Human HLA-DMA-4836H Recombinant Human HLA-DMA Protein, GST-tagged Wheat Germ GST
    Human HLA-DMA-5499HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    HLA-DMA involved in several pathways and played different roles in them. We selected most pathways HLA-DMA participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DMA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome DYNC1LI1; TUBA4L; TUBB6; RILP; FCGR3B; PIKFYVE; TFRC; ATP6V0A1A; CTSL1B; ATP6V1B1
    Cell adhesion molecules (CAMs) CDH4; HLA-DQB1; SDC4; VTCN1; CD8B1; CLDNJ; CD40LG; NCAM2; JAM3; BMA1
    Antigen processing and presentation RFX5; KLRC1; TAP1; IFNG; RFXAP; HLA-A; B2M; HLA-DMA; HLA-DQA2; KIR2DL3
    Intestinal i HLA-DOA; Icosl; HLA-DQA2; CD40LG; CD28; H2-AA; ICOS; MHC2DAB; TNFRSF17; AICDA
    ne network for IgA production TGFB1; IL4; CCL28; HLA-DOB; IL5; HLA-DRA; CCR10; ITGB7; BLB1; PIGR
    Type I diabetes mellitus CPE; PRF1; IL1B; HLA-DQA2; ICA1; GAD1; HLA-DRB1; HLA-B; HLA-DOB; PTPRN
    Leishmaniasis MAPK12; FCGR1; MAPK3; FCGR3B; ITGAM; IL1B; ITGB1; CYBA; NFKBIB; TGFB2
    Toxoplasmosis MAPK10; LY96; IL12A; BCL2L1; MAP3K7; BCL2; PIK3R3; TLR2; RELA; MAP2K6
    Staphylococcus aureus infection SELP; FCGR3; ITGB2; C4A; HLA-DRB5; C1QB; MBL2; FGG; FCGR4; C1S
    Tuberculosis MRC1; H2-AB1; cgr2b; BAX; IL1A; H2-AA; CALML5; FCGR2B; BAD; MAPK11
    Influenza A NUP98; IFNGR2; IRAK4; MAP2K3; HLA-DMB; IFNG; IL12B; HLA-DQA1; NXT2; IL1A
    HTLV-I infection BAX; NFKB1; POLE3; CCND2; WNT16; PDGFRB; LTBR; PIK3R1; HLA-DOB; ATF1
    Herpes simplex infection TRAF1; IL15; PVRL1B; IFNPHI1; SP100; HLA-C; TNFB; BMA2; PILRA; OAS3
    Asthma HLA-DMB; HLA-DPA1; CD40LG; HLA-DQA2; HLA-DRB1; IL5; IL9; IL10; HLA-DMA; HLA-DRB4
    Autoi H2-AB1; CD80; CD40LG; IFNA12; Il2; HLA-DQB1; HLA-DRB1; TSHB; HLA-DQA1; HLA-DMB
    ne thyroid disease H2-Q10; HLA-DRA; HLA-DQB1; TG; TSHB; HLA-DRB4; Ifna11; HLA-B; IFNA8; IFNA12
    Inflammatory bowel disease (IBD) HLA-DRB5; IL6; IL1A; HLA-DQB1; IL17F; HLA-DOA; IL13; Il23a; Il4ra; IFNGR2
    Systemic lupus erythematosus HIST1H2BQ; HIST1H2BK; HIST1H2AM; TRIM21; FCGR1; HLA-DRB4; HIST1H2AJ; FCGR3B; HIST1H2AK; H2AFY2
    Rheumatoid arthritis ITGB2L; CCL3L3; FLT1; HLA-DOB; ATP6V0E2; IL15; ICAM1; HLA-DQA2; TNFSF13; ITGB2
    Allograft rejection HLA-G; HLA-DOB; CD40; HLA-DMB; Il2; HLA-DRB1; FAS; HLA-B; HLA-DRB4; HLA-DMA
    Graft-versus-host disease KIR3DL2; HLA-DRB4; HLA-DRB1; GZMB; HLA-DMB; TNF; HLA-C; FAS; HLA-F; HLA-DRB3
    Viral myocarditis HLA-DQA2; HLA-DRB3; ABL1; CD86; HLA-DPB1; HLA-E; HLA-A; EIF4G2; HLA-DOA; RAC1

    HLA-DMA has several biochemical functions, for example, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DMA itself. We selected most functions HLA-DMA had, and list some proteins which have the same functions with HLA-DMA. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein complex binding ATP1B1; HSPA8; HLA-DMA; HSP90AA1; HSP90AB1; HLA-DOA; HLA-DMB; HLA-DRA; PKM; MS4A1

    HLA-DMA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DMA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DMA.

    HLA-DRB1; HLA-DMB

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