HLA-DQB2 Protein

HLA-DQB2

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HLA-DQB2

Official Full Name major histocompatibility complex, class II, DQ beta 2
Background HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus.
Synonyms HLA-DQB2; major histocompatibility complex, class II, DQ beta 2; HLA DXB; HLA class II histocompatibility antigen, DX beta chain; HLA DQB1; OTTHUMP00000029168; OTTHUMP00000029169; OTTHUMP00000178595; OTTHUMP00000178596; major histocompatibility complex, class II, DQ beta 1; DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB); HLA-DXB; HLA-DQB1
    • Species :
    • Human
    • Source :
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • GST
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DQB2-313H Recombinant Human HLA-DQB2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HLA-DQB2-4750H Recombinant Human HLA-DQB2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HLA-DQB2-4846H Recombinant Human HLA-DQB2 Protein, GST-tagged Wheat Germ GST
    Human HLA-DQB2-796HCL Recombinant Human HLA-DQB2 cell lysate N/A

    HLA-DQB2 involved in several pathways and played different roles in them. We selected most pathways HLA-DQB2 participated on our site, such as Adaptive Immune System, Costimulation by the CD28 family, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System KIF4; MICA; FGFR1B; KIF3B; DYNC1H1; MGC174155; RAP1GAP2; UBA5; FCGR1B; AP1S3A
    Costimulation by the CD28 family CSK; PDPK1A; HLA-DQB2; THEM4; CTLA4; BTLA; MAP3K8; MAPKAP1
    Cytokine Signaling in Immune system PHB; TRIM62; HAVCR2; DUSP2; EGR1; MARK3; EIF4E3; PAQR3A; OSTN; DPF1
    Downstream TCR signaling TRAT1; HLA-DQB2; UBE2V1
    Generation of second messenger molecules GRAP2A; ITK; GRAP2B; HLA-DQB2; EVL
    Immune System ICAM4; NCKIPSD; CTSLL; CYBA; RAPGEF3; RNF216; FAM49BA; IRAK3; KIF2A; ATG7
    Interferon Signaling IFI6; IFITM2; TRIM17; TRIM6; IFI35; TRIM5; IRF2; ARIH1L; TRIM31; IFIT14
    Interferon gamma signaling HLA-DQB2; TRIM68; TRIM46; TRIM62; TRIM26; FCGR1B; IFI30; TRIM38; TRIM17; TRIM5

    HLA-DQB2 has several biochemical functions, for example, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQB2 itself. We selected most functions HLA-DQB2 had, and list some proteins which have the same functions with HLA-DQB2. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II receptor activity HLA-DRB4; HLA-DOB; HLA-DOA; HLA-DQB2; HLA-DQA2; HLA-DRB1; HLA-DPA1; HLA-DRB3; HLA-DRA; HLA-DQB1

    HLA-DQB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQB2.

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