|Official Full Name||major histocompatibility complex, class II, DQ beta 2|
|Background||HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus.|
|Synonyms||HLA-DQB2; major histocompatibility complex, class II, DQ beta 2; HLA DXB; HLA class II histocompatibility antigen, DX beta chain; HLA DQB1; OTTHUMP00000029168; OTTHUMP00000029169; OTTHUMP00000178595; OTTHUMP00000178596; major histocompatibility complex, class II, DQ beta 1; DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB); HLA-DXB; HLA-DQB1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
HLA-DQB2 involved in several pathways and played different roles in them. We selected most pathways HLA-DQB2 participated on our site, such as Adaptive Immune System, Costimulation by the CD28 family, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Adaptive Immune System||KIF4; MICA; FGFR1B; KIF3B; DYNC1H1; MGC174155; RAP1GAP2; UBA5; FCGR1B; AP1S3A|
|Costimulation by the CD28 family||CSK; PDPK1A; HLA-DQB2; THEM4; CTLA4; BTLA; MAP3K8; MAPKAP1|
|Cytokine Signaling in Immune system||PHB; TRIM62; HAVCR2; DUSP2; EGR1; MARK3; EIF4E3; PAQR3A; OSTN; DPF1|
|Downstream TCR signaling||TRAT1; HLA-DQB2; UBE2V1|
|Generation of second messenger molecules||GRAP2A; ITK; GRAP2B; HLA-DQB2; EVL|
|Immune System||ICAM4; NCKIPSD; CTSLL; CYBA; RAPGEF3; RNF216; FAM49BA; IRAK3; KIF2A; ATG7|
|Interferon Signaling||IFI6; IFITM2; TRIM17; TRIM6; IFI35; TRIM5; IRF2; ARIH1L; TRIM31; IFIT14|
|Interferon gamma signaling||HLA-DQB2; TRIM68; TRIM46; TRIM62; TRIM26; FCGR1B; IFI30; TRIM38; TRIM17; TRIM5|
HLA-DQB2 has several biochemical functions, for example, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQB2 itself. We selected most functions HLA-DQB2 had, and list some proteins which have the same functions with HLA-DQB2. You can find most of the proteins on our site.
|MHC class II receptor activity||HLA-DRB4; HLA-DOB; HLA-DOA; HLA-DQB2; HLA-DQA2; HLA-DRB1; HLA-DPA1; HLA-DRB3; HLA-DRA; HLA-DQB1|
HLA-DQB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQB2.